KEGG   PATHWAY: bbh00260
Entry
bbh00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bordetella bronchiseptica 253
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bbh00260  Glycine, serine and threonine metabolism
bbh00260

Module
bbh_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bbh00260]
bbh_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bbh00260]
bbh_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:bbh00260]
bbh_M00621  Glycine cleavage system [PATH:bbh00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bordetella bronchiseptica 253 [GN:bbh]
Gene
BN112_1776  ask; aspartokinase [KO:K00928] [EC:2.7.2.4]
BN112_1384  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BN112_1589  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BN112_1415  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
BN112_1588  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
BN112_4673  threonine synthase [KO:K01733] [EC:4.2.3.1]
BN112_4692  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BN112_2727  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BN112_4074  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BN112_3752  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BN112_2988  putative 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BN112_1641  putative 2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BN112_4304  garK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
BN112_3119  gpmA; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
BN112_2010  gpmB; probable phosphoglycerate mutase 2 [KO:K15634] [EC:5.4.2.11]
BN112_1931  Putative dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BN112_3691  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BN112_3948  serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BN112_1276  serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BN112_4596  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
BN112_2586  gcvP; glycine cleavage system P protein [KO:K00281] [EC:1.4.4.2]
BN112_2588  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
BN112_0812  putative pyridine nucleotide-disulfide oxidoreductase [KO:K00382] [EC:1.8.1.4]
BN112_0355  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BN112_4749  odhL; 2-oxoglutarate dehydrogenase complex, E3 component [KO:K00382] [EC:1.8.1.4]
BN112_3728  lpdA; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
BN112_2587  gcvH; glycine cleavage system H protein [KO:K02437]
BN112_4531  pssA; putative CDP-diacylglycerol--serine O-phosphatidyltransferase protein [KO:K17103] [EC:2.7.8.8]
BN112_1037  sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
BN112_2191  ilvA; threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
BN112_2146  putative amino-acid dehydratase [KO:K01754] [EC:4.3.1.19]
BN112_4536  tdcB; threonine dehydratase catabolic [KO:K01754] [EC:4.3.1.19]
BN112_3933  ilvA; threonine dehydratase biosynthetic [KO:K01754] [EC:4.3.1.19]
BN112_3092  ptpT; putative deaminase [KO:K01753] [EC:4.3.1.18]
BN112_4642  trpA; tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
BN112_4641  trpB; tryptophan synthase beta chain [KO:K01696] [EC:4.2.1.20]
BN112_1021  ectB; diaminobutyrate--pyruvate aminotransferase [KO:K00836] [EC:2.6.1.76]
BN112_1022  ectA; L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
BN112_1020  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
BN112_1019  putative L-proline 4-hydroxylase [KO:K10674] [EC:1.14.11.55]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bbh00010  Glycolysis / Gluconeogenesis
bbh00020  Citrate cycle (TCA cycle)
bbh00230  Purine metabolism
bbh00250  Alanine, aspartate and glutamate metabolism
bbh00270  Cysteine and methionine metabolism
bbh00290  Valine, leucine and isoleucine biosynthesis
bbh00300  Lysine biosynthesis
bbh00330  Arginine and proline metabolism
bbh00460  Cyanoamino acid metabolism
bbh00470  D-Amino acid metabolism
bbh00564  Glycerophospholipid metabolism
bbh00620  Pyruvate metabolism
bbh00630  Glyoxylate and dicarboxylate metabolism
bbh00640  Propanoate metabolism
bbh00680  Methane metabolism
bbh00860  Porphyrin metabolism
bbh00920  Sulfur metabolism
KO pathway
ko00260   
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