KEGG   PATHWAY: bfu00260
Entry
bfu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Botrytis cinerea (gray mold)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bfu00260  Glycine, serine and threonine metabolism
bfu00260

Module
bfu_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bfu00260]
bfu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bfu00260]
bfu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:bfu00260]
bfu_M00621  Glycine cleavage system [PATH:bfu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Botrytis cinerea (gray mold) [GN:bfu]
Gene
BCIN_03g02350  Bchom3; Bchom3 [KO:K00928] [EC:2.7.2.4]
BCIN_01g01820  Bchom2; Bchom2 [KO:K00133] [EC:1.2.1.11]
BCIN_11g00440  Bchom6; Bchom6 [KO:K00003] [EC:1.1.1.3]
BCIN_03g05350  Bcthr1; Bcthr1 [KO:K00872] [EC:2.7.1.39]
BCIN_13g05020  Bcthr4; Bcthr4 [KO:K01733] [EC:4.2.3.1]
BCIN_02g03790  hypothetical protein [KO:K01620] [EC:4.1.2.48]
BCIN_02g08600  Bcshm2; Bcshm2 [KO:K00600] [EC:2.1.2.1]
BCIN_04g00550  hypothetical protein [KO:K00600] [EC:2.1.2.1]
BCIN_14g00830  Bcagx1; Bcagx1 [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
BCIN_02g06270  hypothetical protein [KO:K15633] [EC:5.4.2.12]
BCIN_07g04150  hypothetical protein [KO:K15918] [EC:2.7.1.31]
BCIN_09g05520  hypothetical protein [KO:K15918] [EC:2.7.1.31]
BCIN_03g06180  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BCIN_13g03220  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BCIN_16g04730  Bcser1; Bcser1 [KO:K00831] [EC:2.6.1.52]
BCIN_01g04260  Bcser2; Bcser2 [KO:K01079] [EC:3.1.3.3]
BCIN_12g05190  hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BCIN_10g03090  Bchem1; Bchem1 [KO:K00643] [EC:2.3.1.37]
BCIN_02g05100  hypothetical protein [KO:K00276] [EC:1.4.3.21]
BCIN_05g07030  hypothetical protein [KO:K00276] [EC:1.4.3.21]
BCIN_01g08900  hypothetical protein [KO:K00276] [EC:1.4.3.21]
BCIN_08g01460  Bcgcv2; Bcgcv2 [KO:K00281] [EC:1.4.4.2]
BCIN_11g04890  hypothetical protein [KO:K00605] [EC:2.1.2.10]
BCIN_02g06400  hypothetical protein [KO:K00382] [EC:1.8.1.4]
BCIN_03g07290  Bcgcv3; Bcgcv3 [KO:K02437]
BCIN_13g00810  Bcdao3; Bcdao3 [KO:K00273] [EC:1.4.3.3]
BCIN_12g04240  Bcdao1; Bcdao1 [KO:K00273] [EC:1.4.3.3]
BCIN_02g06660  Bccho1; Bccho1 [KO:K17103] [EC:2.7.8.8]
BCIN_08g04030  hypothetical protein [KO:K00130] [EC:1.2.1.8]
BCIN_11g04320  Bcdao2; Bcdao2 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
BCIN_06g00740  Bcdao5; Bcdao5 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
BCIN_06g06380  Bcdao4; Bcdao4 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
BCIN_16g03500  Bccys4; Bccys4 [KO:K01697] [EC:4.2.1.22]
BCIN_02g03490  Bccys3; Bccys3 [KO:K01758] [EC:4.4.1.1]
BCIN_01g00210  Bcilv1; Bcilv1 [KO:K01754] [EC:4.3.1.19]
BCIN_04g03090  hypothetical protein [KO:K01754] [EC:4.3.1.19]
BCIN_05g03750  Bccha1; Bccha1 [KO:K17989] [EC:4.3.1.17 4.3.1.19]
BCIN_05g04050  Bcdsd1; Bcdsd1 [KO:K20498] [EC:4.3.1.18]
BCIN_04g03060  Bctrp5; Bctrp5 [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bfu00010  Glycolysis / Gluconeogenesis
bfu00020  Citrate cycle (TCA cycle)
bfu00230  Purine metabolism
bfu00250  Alanine, aspartate and glutamate metabolism
bfu00270  Cysteine and methionine metabolism
bfu00290  Valine, leucine and isoleucine biosynthesis
bfu00300  Lysine biosynthesis
bfu00330  Arginine and proline metabolism
bfu00460  Cyanoamino acid metabolism
bfu00470  D-Amino acid metabolism
bfu00564  Glycerophospholipid metabolism
bfu00600  Sphingolipid metabolism
bfu00620  Pyruvate metabolism
bfu00630  Glyoxylate and dicarboxylate metabolism
bfu00640  Propanoate metabolism
bfu00680  Methane metabolism
bfu00860  Porphyrin metabolism
bfu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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