KEGG   PATHWAY: bmh00260
Entry
bmh00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Bacillus megaterium WSH-002
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bmh00260  Glycine, serine and threonine metabolism
bmh00260

Module
bmh_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bmh00260]
bmh_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bmh00260]
bmh_M00555  Betaine biosynthesis, choline => betaine [PATH:bmh00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Bacillus megaterium WSH-002 [GN:bmh]
Gene
BMWSH_0524  lysC; Aspartokinase 2 [KO:K00928] [EC:2.7.2.4]
BMWSH_1089  dapG; Aspartokinase 1 [KO:K00928] [EC:2.7.2.4]
BMWSH_3117  yclM; Aspartokinase [KO:K00928] [EC:2.7.2.4]
BMWSH_1088  asd; Aspartate-semialdehyde dehydrogenase, putative [KO:K00133] [EC:1.2.1.11]
BMWSH_0299  hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
BMWSH_0301  thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]
BMWSH_0300  Threonine synthase [KO:K01733] [EC:4.2.3.1]
BMWSH_1775  thrC; Threonine synthase-like protein [KO:K01733] [EC:4.2.3.1]
BMWSH_0118  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BMWSH_2433  yxaA; Glycerate kinase GlxK [KO:K00865] [EC:2.7.1.165]
BMWSH_4679  gpm; putative Phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
BMWSH_1407  gpmA; Phosphoglycerate mutase family protein [KO:K01834] [EC:5.4.2.11]
BMWSH_0227  pgm; Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [KO:K15633] [EC:5.4.2.12]
BMWSH_0866  serA; Phosphoglycerate dehydrogenase SerA [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BMWSH_2815  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BMWSH_4651  serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
BMWSH_2680  ysaA; HAD-superfamily hydrolase, subfamily IA, variant 1 [KO:K25528] [EC:3.1.3.3]
BMWSH_3670  bioF; Pyridoxal phosphate-dependent acyltransferase, putative [KO:K00639] [EC:2.3.1.29]
BMWSH_0752  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
BMWSH_0795  lpdV; 3-methyl-2-oxobutanoate dehydrogenase complex, dihydrolipoamide dehydrogenase component [KO:K00382] [EC:1.8.1.4]
BMWSH_3881  pdhD; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BMWSH_3375  acoL; Acetoin dehydrogenase complex, dihydrolipoamide dehydrogenase component [KO:K00382] [EC:1.8.1.4]
BMWSH_0271  gcvH; glycine decarboxylase complex H-protein [KO:K02437]
BMWSH_2627  pssA2; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
BMWSH_0654  pssA; Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) [KO:K17103] [EC:2.7.8.8]
BMWSH_0170  Alcohol dehydrogenase [KO:K11440] [EC:1.1.1.1]
BMWSH_0171  Aldehyde dehydrogenase (Acceptor) [KO:K00130] [EC:1.2.1.8]
BMWSH_2980  Aldehyde dehydrogenase (Acceptor) [KO:K00130] [EC:1.2.1.8]
BMWSH_4379  gbsA; Aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BMWSH_3690  Aminomethyltransferase GcvT_2 [KO:K00309] [EC:1.5.3.10]
BMWSH_3689  solA; Glycine/D-amino acid oxidase, deaminating [KO:K00301] [EC:1.5.3.1]
BMWSH_1001  sdaAB; L-serine dehydratase beta subunit [KO:K01752] [EC:4.3.1.17]
BMWSH_1002  sdaAA; L-serine ammonia-lyase alpha chain [KO:K01752] [EC:4.3.1.17]
BMWSH_1168  ilvA; Threonine dehydratase (Threonine ammonia-lyase) [KO:K01754] [EC:4.3.1.19]
BMWSH_3178  dsdA; D-serine deaminase (Dehydratase) [KO:K01753] [EC:4.3.1.18]
BMWSH_1591  racD; Aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
BMWSH_1164  Diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bmh00010  Glycolysis / Gluconeogenesis
bmh00020  Citrate cycle (TCA cycle)
bmh00230  Purine metabolism
bmh00250  Alanine, aspartate and glutamate metabolism
bmh00270  Cysteine and methionine metabolism
bmh00290  Valine, leucine and isoleucine biosynthesis
bmh00300  Lysine biosynthesis
bmh00330  Arginine and proline metabolism
bmh00460  Cyanoamino acid metabolism
bmh00470  D-Amino acid metabolism
bmh00564  Glycerophospholipid metabolism
bmh00600  Sphingolipid metabolism
bmh00620  Pyruvate metabolism
bmh00630  Glyoxylate and dicarboxylate metabolism
bmh00640  Propanoate metabolism
bmh00680  Methane metabolism
bmh00860  Porphyrin metabolism
bmh00920  Sulfur metabolism
KO pathway
ko00260   
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