KEGG   PATHWAY: bve00260
Entry
bve00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Burkholderia vietnamiensis LMG 10929
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
bve00260  Glycine, serine and threonine metabolism
bve00260

Module
bve_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:bve00260]
bve_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:bve00260]
bve_M00555  Betaine biosynthesis, choline => betaine [PATH:bve00260]
bve_M00621  Glycine cleavage system [PATH:bve00260]
bve_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:bve00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Burkholderia vietnamiensis LMG 10929 [GN:bve]
Gene
AK36_1813  aspartate kinase, monofunctional class [KO:K00928] [EC:2.7.2.4]
AK36_4379  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AK36_2063  oxidoreductase, NAD-binding Rossmann fold family protein [KO:K00003] [EC:1.1.1.3]
AK36_4455  thrB; homoserine kinase [KO:K02204] [EC:2.7.1.39]
AK36_2064  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
AK36_3114  beta-eliminating lyase family protein [KO:K01620] [EC:4.1.2.48]
AK36_66  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
AK36_4764  beta-eliminating lyase family protein [KO:K00600] [EC:2.1.2.1]
AK36_3338  glyA2; serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
AK36_953  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AK36_5864  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K12972] [EC:1.1.1.79 1.1.1.81]
AK36_2196  ghrB; glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AK36_2832  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AK36_1956  glycerate kinase family protein [KO:K00865] [EC:2.7.1.165]
AK36_1044  gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
AK36_155  histidine phosphatase super family protein [KO:K15634] [EC:5.4.2.11]
AK36_784  D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AK36_2895  serC; phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
AK36_2135  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
AK36_67  short chain dehydrogenase family protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
AK36_4921  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
AK36_4922  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
AK36_619  gcvP; glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
AK36_617  gcvT; glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
AK36_2376  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AK36_1753  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
AK36_618  gcvH; glycine cleavage system H protein [KO:K02437]
AK36_1621  pssA; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
AK36_3330  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AK36_3331  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AK36_3345  ring hydroxylating alpha subunit family protein [KO:K00479] [EC:1.14.13.251]
AK36_3346  2Fe-2S iron-sulfur cluster binding domain protein [KO:K21832] [EC:1.14.13.251]
AK36_3341  flavin oxidoreductase / NADH oxidase family protein [KO:K21833] [EC:1.5.7.3]
AK36_3342  4Fe-4S dicluster domain protein [KO:K21834]
AK36_3343  electron transfer flavoFAD-binding domain protein [KO:K25960]
AK36_3344  electron transfer flavodomain protein [KO:K25961]
AK36_3303  sarcosine oxidase, alpha subunit [KO:K00302] [EC:1.5.3.24 1.5.3.1]
AK36_3301  sarcosine oxidase, beta subunit [KO:K00303] [EC:1.5.3.24 1.5.3.1]
AK36_3304  sarcosine oxidase, gamma subunit [KO:K00305] [EC:1.5.3.24 1.5.3.1]
AK36_3302  soxD; subunit delta of sarcosine oxidase [KO:K00304] [EC:1.5.3.24 1.5.3.1]
AK36_3300  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AK36_621  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
AK36_1160  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
AK36_3740  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
AK36_1932  psdht; phenylserine dehydratase [KO:K01754] [EC:4.3.1.19]
AK36_2689  pyridoxal-phosphate dependent enzyme family protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
AK36_1155  putative D-serine deaminase (D-serine dehydratase) protein [KO:K01753] [EC:4.3.1.18]
AK36_3435  dsdA; D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
AK36_1745  aspartate racemase family protein [KO:K25316] [EC:5.1.1.10]
AK36_4373  trpA; tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]
AK36_4375  trpB; tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]
AK36_5672  2,4-diaminobutyrate 4-transaminase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
bve00010  Glycolysis / Gluconeogenesis
bve00020  Citrate cycle (TCA cycle)
bve00230  Purine metabolism
bve00250  Alanine, aspartate and glutamate metabolism
bve00270  Cysteine and methionine metabolism
bve00290  Valine, leucine and isoleucine biosynthesis
bve00300  Lysine biosynthesis
bve00330  Arginine and proline metabolism
bve00460  Cyanoamino acid metabolism
bve00470  D-Amino acid metabolism
bve00564  Glycerophospholipid metabolism
bve00600  Sphingolipid metabolism
bve00620  Pyruvate metabolism
bve00630  Glyoxylate and dicarboxylate metabolism
bve00640  Propanoate metabolism
bve00680  Methane metabolism
bve00860  Porphyrin metabolism
bve00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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