KEGG   PATHWAY: cit04626
Entry
cit04626                    Pathway                                
Name
Plant-pathogen interaction - Citrus sinensis (Valencia orange)
Description
Plants lack animal-like adaptive immunity mechanisms, and therefore have evolved a specific system with multiple layers against invading pathogens. The primary response includes the perception of pathogens by cell-surface pattern-recognition receptors (PRRs) and is referred to as PAMP-triggered immunity (PTI). Activation of FLS2 and EFR triggers MAPK signaling pathway that activates defense genes for antimictobial compounds. The increase in the cytosolic Ca2+ concentration is also a regulator for production of reactive oxygen species and localized programmed cell death/hypersensitive response. The secondary response is called effector-triggered immunity (ETI). Pathogens can acquire the ability to suppress PTI by directly injecting effector proteins into the plant cell through secretion systems. In addition, pathogens can manipulate plant hormone signaling pathways to evade host immune responses using coronatine toxin. Some plants possess specific intracellular surveillance proteins (R proteins) to monitor the presence of pathogen virulence proteins. This ETI occurs with localized programmed cell death to arrest pathogen growth, resulting in cultivar-specific disease resistance.
Class
Organismal Systems; Environmental adaptation
Pathway map
cit04626  Plant-pathogen interaction
cit04626

Organism
Citrus sinensis (Valencia orange) [GN:cit]
Gene
102620953  calcium-dependent protein kinase 28-like isoform X2 [KO:K13412] [EC:2.7.11.1]
102608665  calcium-dependent protein kinase SK5 [KO:K13412] [EC:2.7.11.1]
102606999  calcium-dependent protein kinase 21-like [KO:K13412] [EC:2.7.11.1]
102607143  calcium-dependent protein kinase 33-like [KO:K13412] [EC:2.7.11.1]
102630649  calcium-dependent protein kinase 33-like [KO:K13412] [EC:2.7.11.1]
102611873  calcium-dependent protein kinase 10 [KO:K13412] [EC:2.7.11.1]
102610908  calcium-dependent protein kinase 13 isoform X1 [KO:K13412] [EC:2.7.11.1]
102627915  calcium and calcium/calmodulin-dependent serine/threonine-protein kinase-like [KO:K13412] [EC:2.7.11.1]
102612197  calcium-dependent protein kinase 1 isoform X1 [KO:K13412] [EC:2.7.11.1]
102623817  calcium-dependent protein kinase 11 isoform X1 [KO:K13412] [EC:2.7.11.1]
102622422  calcium-dependent protein kinase 32 isoform X1 [KO:K13412] [EC:2.7.11.1]
102608452  calcium-dependent protein kinase 26 [KO:K13412] [EC:2.7.11.1]
102619481  calcium-dependent protein kinase 29 isoform X1 [KO:K13412] [EC:2.7.11.1]
102607056  calcium-dependent protein kinase 1 [KO:K13412] [EC:2.7.11.1]
102615871  calcium-dependent protein kinase 34 [KO:K13412] [EC:2.7.11.1]
102630407  calcium-dependent protein kinase 8 [KO:K13412] [EC:2.7.11.1]
102624859  calcium-dependent protein kinase 24 [KO:K13412] [EC:2.7.11.1]
102610700  calcium-dependent protein kinase 26-like [KO:K13412] [EC:2.7.11.1]
102630343  calcium-dependent protein kinase 33-like [KO:K13412] [EC:2.7.11.1]
102628905  calcium-dependent protein kinase 33-like isoform X1 [KO:K13412] [EC:2.7.11.1]
107176513  calcium-dependent protein kinase 2-like [KO:K13412] [EC:2.7.11.1]
127898662  calcium-dependent protein kinase 33-like [KO:K13412] [EC:2.7.11.1]
102607099  CDPK-related kinase 5 [KO:K13412] [EC:2.7.11.1]
102612077  CDPK-related kinase 7 [KO:K13412] [EC:2.7.11.1]
102615289  CDPK-related kinase 3 isoform X2 [KO:K13412] [EC:2.7.11.1]
102630119  CDPK-related kinase 4-like isoform X1 [KO:K13412] [EC:2.7.11.1]
102609573  CDPK-related kinase 5-like [KO:K13412] [EC:2.7.11.1]
102610370  respiratory burst oxidase homolog protein B [KO:K13447] [EC:1.6.3.- 1.11.1.-]
102615056  respiratory burst oxidase homolog protein C [KO:K13447] [EC:1.6.3.- 1.11.1.-]
102626296  respiratory burst oxidase homolog protein E isoform X1 [KO:K13447] [EC:1.6.3.- 1.11.1.-]
102617682  respiratory burst oxidase homolog protein A-like [KO:K13447] [EC:1.6.3.- 1.11.1.-]
102610069  respiratory burst oxidase homolog protein A [KO:K13447] [EC:1.6.3.- 1.11.1.-]
102616720  respiratory burst oxidase homolog protein D [KO:K13447] [EC:1.6.3.- 1.11.1.-]
102629098  probable cyclic nucleotide-gated ion channel 16 [KO:K05391]
102622071  protein CNGC15b-like [KO:K05391]
102621236  protein CNGC15b-like [KO:K05391]
102631299  protein CNGC15b-like [KO:K05391]
102616094  cyclic nucleotide-gated ion channel 17-like [KO:K05391]
102609091  probable cyclic nucleotide-gated ion channel 5 [KO:K05391]
102618760  cyclic nucleotide-gated ion channel 1 [KO:K05391]
102607015  cyclic nucleotide-gated ion channel 1 isoform X1 [KO:K05391]
102614021  cyclic nucleotide-gated ion channel 18 [KO:K05391]
102613080  probable cyclic nucleotide-gated ion channel 20, chloroplastic isoform X1 [KO:K05391]
102617340  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102625224  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102626748  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102627031  cyclic nucleotide-gated ion channel 1-like isoform X1 [KO:K05391]
102628385  cyclic nucleotide-gated ion channel 1 isoform X1 [KO:K05391]
102630710  cyclic nucleotide-gated ion channel 1 [KO:K05391]
102631007  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102631311  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102623213  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102619677  putative cyclic nucleotide-gated ion channel 7 [KO:K05391]
102621025  cyclic nucleotide-gated ion channel 2 [KO:K05391]
102627338  putative cyclic nucleotide-gated ion channel 8 [KO:K05391]
102606712  cyclic nucleotide-gated ion channel 1 isoform X1 [KO:K05391]
102625781  putative cyclic nucleotide-gated ion channel 13 [KO:K05391]
102622729  cyclic nucleotide-gated ion channel 1 [KO:K05391]
102620579  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102623986  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102626259  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102624346  cyclic nucleotide-gated ion channel 4 [KO:K05391]
127898699  cyclic nucleotide-gated ion channel 1-like [KO:K05391]
102615564  cyclic nucleotide-gated ion channel 1-like isoform X1 [KO:K05391]
102610294  calmodulin-7 [KO:K02183]
102610600  calmodulin-7 [KO:K02183]
102615552  calcium-binding protein CP1 [KO:K02183]
102615508  calmodulin isoform X1 [KO:K02183]
102616804  probable calcium-binding protein CML46 [KO:K02183]
102620326  calmodulin-7-like isoform X1 [KO:K02183]
102612314  calcium-binding protein CP1-like [KO:K02183]
102620646  calcium-binding allergen Bet V 3-like [KO:K13448]
102625955  probable calcium-binding protein CML41 [KO:K13448]
102623879  caltractin isoform X2 [KO:K13448]
102613046  probable calcium-binding protein CML11 [KO:K13448]
102624272  calcium-binding protein CML38-like [KO:K13448]
102614964  calmodulin-like protein 30 [KO:K13448]
102613838  calcium-binding protein CML39-like [KO:K13448]
102628322  probable calcium-binding protein CML44 [KO:K13448]
102628611  probable calcium-binding protein CML44 [KO:K13448]
102607242  putative calcium-binding protein CML19 [KO:K13448]
102630096  calmodulin-like protein 8 [KO:K13448]
102613753  calmodulin-like protein 30 [KO:K13448]
102613292  probable calcium-binding protein CML16 [KO:K13448]
102628300  probable calcium-binding protein CML25 [KO:K13448]
102619072  calmodulin-like protein 3 [KO:K13448]
102608263  probable calcium-binding protein CML48 [KO:K13448]
102609927  probable calcium-binding protein CML36 [KO:K13448]
102619846  probable calcium-binding protein CML27 [KO:K13448]
102621120  calmodulin-like protein 3 [KO:K13448]
102625529  probable calcium-binding protein CML21 [KO:K13448]
102628484  calcium-binding protein CBP-like [KO:K13448]
102629574  probable calcium-binding protein CML13 [KO:K13448]
102618314  probable calcium-binding protein CML22 isoform X1 [KO:K13448]
102624861  probable calcium-binding protein CML15 [KO:K13448]
102611750  calmodulin-like protein 11 [KO:K13448]
107178014  probable calcium-binding protein CML16 [KO:K13448]
112498663  polcalcin Nic t 1 [KO:K13448]
112498675  calcium-binding allergen Ole e 8-like [KO:K13448]
102609531  NO-associated protein 1, chloroplastic/mitochondrial [KO:K13427] [EC:1.14.13.39]
102616743  mitogen-activated protein kinase homolog MMK2 isoform X1 [KO:K20600] [EC:2.7.11.24]
127901009  mitogen-activated protein kinase homolog MMK2 isoform X1 [KO:K20600] [EC:2.7.11.24]
102618529  LRR receptor-like serine/threonine-protein kinase FLS2 [KO:K13420] [EC:2.7.11.1]
102622580  receptor kinase-like protein Xa21 isoform X3 [KO:K13420] [EC:2.7.11.1]
107175457  receptor kinase-like protein Xa21 [KO:K13420] [EC:2.7.11.1]
107175569  receptor kinase-like protein Xa21 [KO:K13420] [EC:2.7.11.1]
102626235  probable LRR receptor-like serine/threonine-protein kinase At3g47570 isoform X1 [KO:K13420] [EC:2.7.11.1]
102608793  probable LRR receptor-like serine/threonine-protein kinase At3g47570 isoform X1 [KO:K13420] [EC:2.7.11.1]
102619576  BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1-like [KO:K13416] [EC:2.7.10.1 2.7.11.1]
102629479  elongation factor Tu, mitochondrial [KO:K02358]
102625264  elongation factor Tu, chloroplastic [KO:K02358]
102609376  mitogen-activated protein kinase kinase kinase 1 [KO:K13414] [EC:2.7.11.25]
102625904  mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04368] [EC:2.7.12.2]
102624972  mitogen-activated protein kinase kinase 5 [KO:K13413] [EC:2.7.12.2]
102578011  MAPK1; mitogen-activated protein kinase 1 [KO:K20536] [EC:2.7.11.24]
102629073  mitogen-activated protein kinase homolog MMK1 [KO:K14512] [EC:2.7.11.24]
102621617  WRKY transcription factor WRKY24-like [KO:K13424]
102608921  probable WRKY transcription factor 33 isoform X1 [KO:K13424]
102622218  WRKY transcription factor 22 [KO:K13425]
127901500  WRKY transcription factor 22-like [KO:K13425]
102612567  WRKY transcription factor 22-like isoform X2 [KO:K13426]
102615775  glycerol kinase [KO:K00864] [EC:2.7.1.30]
102623483  pathogenesis-related protein 1 [KO:K13449]
102630276  pathogenesis-related protein 1-like [KO:K13449]
102627480  basic form of pathogenesis-related protein 1-like [KO:K13449]
102626336  pathogenesis-related protein 1-like [KO:K13449]
107178058  pathogenesis-related protein 1B-like [KO:K13449]
102629980  pathogenesis-related protein PR-1 type-like [KO:K13449]
102627194  pathogenesis-related protein 1-like [KO:K13449]
112497323  pathogenesis-related protein 1-like [KO:K13449]
127899051  pathogenesis-related protein 1B-like [KO:K13449]
127899052  pathogenesis-related protein 1B-like [KO:K13449]
102625493  pathogenesis-related genes transcriptional activator PTI5 [KO:K13433]
102622695  pathogenesis-related genes transcriptional activator PTI6-like [KO:K13434]
102619989  PTI1-like tyrosine-protein kinase 1 isoform X1 [KO:K13436] [EC:2.7.11.1]
102623610  pto-interacting protein 1 [KO:K13436] [EC:2.7.11.1]
102616730  pto-interacting protein 1 [KO:K13436] [EC:2.7.11.1]
102622529  RPM1-interacting protein 4-like isoform X1 [KO:K13456]
102623408  RPM1-interacting protein 4-like [KO:K13456]
102624283  RPM1-interacting protein 4-like [KO:K13456]
107175443  RPM1-interacting protein 4-like [KO:K13456]
102608817  RPM1-interacting protein 4 isoform X2 [KO:K13456]
102609562  disease resistance protein RPM1-like [KO:K13457]
102608608  disease resistance protein RPM1-like isoform X1 [KO:K13457]
102626159  disease resistance protein RPM1-like [KO:K13457]
112497927  disease resistance protein RPM1-like [KO:K13457]
127899965  disease resistance protein RPM1-like [KO:K13457]
102626257  cysteine and histidine-rich domain-containing protein RAR1 [KO:K13458]
102623505  protein SGT1 homolog B [KO:K12795]
102611150  heat shock protein 90-6, mitochondrial [KO:K09487]
102629966  heat shock protein 90-5, chloroplastic [KO:K09487]
102608412  endoplasmin homolog [KO:K09487]
102578032  HSP90; HSP90 protein [KO:K04079]
102628301  heat shock protein 83 [KO:K04079]
102616579  heat shock protein 83-like [KO:K04079]
102616385  disease resistance protein RPS2-like isoform X1 [KO:K13459]
102611577  disease resistance protein At4g27190-like [KO:K13459]
102612169  probable disease resistance protein At5g63020 [KO:K13459]
107176547  disease resistance protein At4g27190 [KO:K13459]
102611516  probable disease resistance protein At1g61310 isoform X3 [KO:K13459]
127898746  probable disease resistance protein At4g27220 [KO:K13459]
102607307  probable serine/threonine-protein kinase PBL7 [KO:K13430] [EC:2.7.11.1]
102611789  serine/threonine-protein kinase PBS1 [KO:K13430] [EC:2.7.11.1]
102618041  protein EDS1-like [KO:K18875]
102610464  protein EDS1-like [KO:K18875]
127902605  protein EDS1-like isoform X1 [KO:K18875]
102620490  probable cysteine protease RD19B [KO:K01373] [EC:3.4.22.41]
102608509  cysteine proteinase 15A-like [KO:K01373] [EC:3.4.22.41]
102609994  probable cysteine protease RD19D [KO:K01373] [EC:3.4.22.41]
102614172  3-ketoacyl-CoA synthase 20-like isoform X1 [KO:K15397] [EC:2.3.1.199]
102621546  3-ketoacyl-CoA synthase 7-like [KO:K15397] [EC:2.3.1.199]
102609752  3-ketoacyl-CoA synthase 11 [KO:K15397] [EC:2.3.1.199]
102616191  3-ketoacyl-CoA synthase 15-like [KO:K15397] [EC:2.3.1.199]
102631264  3-ketoacyl-CoA synthase 11 [KO:K15397] [EC:2.3.1.199]
102608675  3-ketoacyl-CoA synthase 20-like isoform X2 [KO:K15397] [EC:2.3.1.199]
102623609  3-ketoacyl-CoA synthase 7 [KO:K15397] [EC:2.3.1.199]
102613293  3-ketoacyl-CoA synthase 6 [KO:K15397] [EC:2.3.1.199]
102608959  3-ketoacyl-CoA synthase 11 [KO:K15397] [EC:2.3.1.199]
102618016  3-ketoacyl-CoA synthase 1 [KO:K15397] [EC:2.3.1.199]
102628384  3-ketoacyl-CoA synthase 5 [KO:K15397] [EC:2.3.1.199]
102617332  3-ketoacyl-CoA synthase 11 [KO:K15397] [EC:2.3.1.199]
102627644  3-ketoacyl-CoA synthase 10 [KO:K15397] [EC:2.3.1.199]
102617526  3-ketoacyl-CoA synthase 12-like [KO:K15397] [EC:2.3.1.199]
102616815  3-ketoacyl-CoA synthase 19 [KO:K15397] [EC:2.3.1.199]
102626149  3-ketoacyl-CoA synthase 4 [KO:K15397] [EC:2.3.1.199]
102611858  3-ketoacyl-CoA synthase 4 [KO:K15397] [EC:2.3.1.199]
102616440  3-ketoacyl-CoA synthase 2-like [KO:K15397] [EC:2.3.1.199]
102613235  WRKY transcription factor 1 [KO:K18834]
102620262  probable WRKY transcription factor 2 isoform X2 [KO:K18835]
102619059  receptor-like protein EIX2 [KO:K13466]
102616085  receptor-like protein EIX1 [KO:K13466]
102606618  receptor-like protein EIX2 [KO:K13466]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C16844  Hydroxyl radical
Reference
PMID:18206360
  Authors
Zipfel C
  Title
Pattern-recognition receptors in plant innate immunity.
  Journal
Curr Opin Immunol 20:10-6 (2008)
DOI:10.1016/j.coi.2007.11.003
Reference
PMID:19748302
  Authors
Chinchilla D, Shan L, He P, de Vries S, Kemmerling B
  Title
One for all: the receptor-associated kinase BAK1.
  Journal
Trends Plant Sci 14:535-41 (2009)
DOI:10.1016/j.tplants.2009.08.002
Reference
PMID:19423812
  Authors
Boller T, He SY
  Title
Innate immunity in plants: an arms race between pattern recognition receptors in plants and effectors in microbial pathogens.
  Journal
Science 324:742-4 (2009)
DOI:10.1126/science.1171647
Reference
PMID:19794842
  Authors
Ma W, Smigel A, Verma R, Berkowitz GA
  Title
Cyclic nucleotide gated channels and related signaling components in plant innate immunity.
  Journal
Plant Signal Behav 4:277-82 (2009)
DOI:10.4161/psb.4.4.8103
Reference
PMID:11875555
  Authors
Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J
  Title
MAP kinase signalling cascade in Arabidopsis innate immunity.
  Journal
Nature 415:977-83 (2002)
DOI:10.1038/415977a
Reference
PMID:15922649
  Authors
Zipfel C, Felix G
  Title
Plants and animals: a different taste for microbes?
  Journal
Curr Opin Plant Biol 8:353-60 (2005)
DOI:10.1016/j.pbi.2005.05.004
Reference
PMID:17451411
  Authors
He P, Shan L, Sheen J
  Title
Elicitation and suppression of microbe-associated molecular pattern-triggered immunity in plant-microbe interactions.
  Journal
Cell Microbiol 9:1385-96 (2007)
DOI:10.1111/j.1462-5822.2007.00944.x
Reference
PMID:17876517
  Authors
de Wit PJ
  Title
How plants recognize pathogens and defend themselves.
  Journal
Cell Mol Life Sci 64:2726-32 (2007)
DOI:10.1007/s00018-007-7284-7
Reference
PMID:16497589
  Authors
Chisholm ST, Coaker G, Day B, Staskawicz BJ
  Title
Host-microbe interactions: shaping the evolution of the plant immune response.
  Journal
Cell 124:803-14 (2006)
DOI:10.1016/j.cell.2006.02.008
Reference
PMID:16677430
  Authors
McHale L, Tan X, Koehl P, Michelmore RW
  Title
Plant NBS-LRR proteins: adaptable guards.
  Journal
Genome Biol 7:212 (2006)
DOI:10.1186/gb-2006-7-4-212
Reference
PMID:11459065
  Authors
Dangl JL, Jones JD
  Title
Plant pathogens and integrated defence responses to infection.
  Journal
Nature 411:826-33 (2001)
DOI:10.1038/35081161
Reference
PMID:17108957
  Authors
Jones JD, Dangl JL
  Title
The plant immune system.
  Journal
Nature 444:323-9 (2006)
DOI:10.1038/nature05286
Reference
PMID:16697674
  Authors
da Cunha L, McFall AJ, Mackey D
  Title
Innate immunity in plants: a continuum of layered defenses.
  Journal
Microbes Infect 8:1372-81 (2006)
DOI:10.1016/j.micinf.2005.12.018
Reference
PMID:15862106
  Authors
Mudgett MB
  Title
New insights to the function of phytopathogenic bacterial type III effectors in plants.
  Journal
Annu Rev Plant Biol 56:509-31 (2005)
DOI:10.1146/annurev.arplant.56.032604.144218
Reference
PMID:17714518
  Authors
Ma W, Berkowitz GA
  Title
The grateful dead: calcium and cell death in plant innate immunity.
  Journal
Cell Microbiol 9:2571-85 (2007)
DOI:10.1111/j.1462-5822.2007.01031.x
Reference
PMID:14711430
  Authors
Schulze-Lefert P
  Title
Plant immunity: the origami of receptor activation.
  Journal
Curr Biol 14:R22-4 (2004)
DOI:10.1016/j.cub.2003.12.017
Reference
PMID:9868361
  Authors
Van der Biezen EA, Jones JD
  Title
Plant disease-resistance proteins and the gene-for-gene concept.
  Journal
Trends Biochem Sci 23:454-6 (1998)
DOI:10.1016/S0968-0004(98)01311-5
Reference
PMID:16936700
  Authors
Abramovitch RB, Anderson JC, Martin GB
  Title
Bacterial elicitation and evasion of plant innate immunity.
  Journal
Nat Rev Mol Cell Biol 7:601-11 (2006)
DOI:10.1038/nrm1984
Related
pathway
cit04144  Endocytosis
KO pathway
ko04626   
LinkDB

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