KEGG   PATHWAY: clud03420
Entry
clud03420                   Pathway                                
Name
Nucleotide excision repair - Canis lupus dingo (dingo)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
clud03420  Nucleotide excision repair
clud03420

Other DBs
GO: 0006289
Organism
Canis lupus dingo (dingo) [GN:clud]
Gene
112667276  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
112656111  CUL4A; cullin-4A [KO:K10609]
112649147  CUL4B; cullin-4B isoform X2 [KO:K10609]
112659550  DDB1; DNA damage-binding protein 1 [KO:K10610]
112663311  DDB2; DNA damage-binding protein 2 isoform X2 [KO:K10140]
112660990  XPC; DNA repair protein complementing XP-C cells isoform X1 [KO:K10838]
112649677  RAD23B; UV excision repair protein RAD23 homolog B isoform X1 [KO:K10839]
112666589  RAD23A; UV excision repair protein RAD23 homolog A isoform X1 [KO:K10839]
112668411  CETN2; centrin-2 [KO:K10840]
112659833  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
112671983  ERCC6; DNA excision repair protein ERCC-6 [KO:K10841]
112653252  UVSSA; UV-stimulated scaffold protein A isoform X1 [KO:K23720]
112647455  POLR2A; DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]
112652287  POLR2B; DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
112660458  POLR2C; DNA-directed RNA polymerase II subunit RPB3 [KO:K03011]
112652413  POLR2D; DNA-directed RNA polymerase II subunit RPB4 isoform X2 [KO:K03012]
112666170  POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X2 [KO:K03013]
112668238  POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 isoform X2 [KO:K03014]
112659371  POLR2G; DNA-directed RNA polymerase II subunit RPB7 isoform X1 [KO:K03015]
112662719  POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 [KO:K03016]
112643613  POLR2I; DNA-directed RNA polymerase II subunit RPB9 [KO:K03017]
112663254  POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
112662095  POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009]
112671754  DNA-directed RNA polymerases I, II, and III subunit RPABC4-like [KO:K03009]
112658086  DNA-directed RNA polymerases I, II, and III subunit RPABC4-like [KO:K03009]
112646186  POLR2J; DNA-directed RNA polymerase II subunit RPB11-a isoform X1 [KO:K03008]
112675865  POLR2M; protein GRINL1A [KO:K21987]
112660268  CDK7; cyclin-dependent kinase 7 isoform X4 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
112658079  MNAT1; CDK-activating kinase assembly factor MAT1 isoform X1 [KO:K10842]
112653255  CCNH; cyclin-H isoform X1 [KO:K06634]
112652433  ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:5.6.2.4]
112645304  ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1 [KO:K10844] [EC:5.6.2.3]
112649172  GTF2H5; general transcription factor IIH subunit 5 [KO:K10845]
112667720  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
112660083  GTF2H2; general transcription factor IIH subunit 2 [KO:K03142]
112676459  GTF2H3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
125752290  GTF2H4; general transcription factor IIH subunit 4 isoform X1 [KO:K03144]
112655937  ERCC5; DNA excision repair protein ERCC-5 isoform X2 [KO:K10846]
112650579  XPA; DNA repair protein complementing XP-A cells isoform X1 [KO:K10847]
112677564  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
112660020  RPA2; replication protein A 32 kDa subunit [KO:K10739]
112674858  RPA3; replication protein A 14 kDa subunit [KO:K10740]
112659604  replication protein A 14 kDa subunit-like [KO:K10740]
112640354  ERCC4; DNA repair endonuclease XPF isoform X1 [KO:K10848] [EC:3.1.-.-]
112645302  ERCC1; DNA excision repair protein ERCC-1 isoform X1 [KO:K10849]
112645105  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
112650673  POLD2; DNA polymerase delta subunit 2 isoform X5 [KO:K02328]
112667424  POLD3; DNA polymerase delta subunit 3 isoform X3 [KO:K03504]
112659390  POLD4; DNA polymerase delta subunit 4 isoform X2 [KO:K03505]
112676379  POLE; DNA polymerase epsilon catalytic subunit A isoform X1 [KO:K02324] [EC:2.7.7.7]
112657314  POLE2; DNA polymerase epsilon subunit 2 isoform X3 [KO:K02325] [EC:2.7.7.7]
112649884  POLE3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]
112664265  POLE4; DNA polymerase epsilon subunit 4 isoform X1 [KO:K03506] [EC:2.7.7.7]
112673637  PCNA; proliferating cell nuclear antigen isoform X1 [KO:K04802]
112653443  RFC1; replication factor C subunit 1 isoform X3 [KO:K10754]
112646132  RFC2; replication factor C subunit 2 isoform X1 [KO:K10755]
112662639  RFC4; replication factor C subunit 4 isoform X1 [KO:K10755]
112669417  RFC3; replication factor C subunit 3 isoform X1 [KO:K10756]
112676634  RFC5; replication factor C subunit 5 isoform X1 [KO:K10756]
112645220  LIG1; DNA ligase 1 isoform X3 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
clud03020  RNA polymerase
clud04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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