KEGG   PATHWAY: csv00260
Entry
csv00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Cucumis sativus (cucumber)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
csv00260  Glycine, serine and threonine metabolism
csv00260

Module
csv_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:csv00260]
csv_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:csv00260]
csv_M00555  Betaine biosynthesis, choline => betaine [PATH:csv00260]
csv_M00621  Glycine cleavage system [PATH:csv00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Cucumis sativus (cucumber) [GN:csv]
Gene
101222001  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
101202843  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
101206329  uncharacterized protein LOC101206329 [KO:K00133] [EC:1.2.1.11]
101222129  homoserine kinase [KO:K00872] [EC:2.7.1.39]
101208070  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
101204787  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
101207481  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
101205504  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
101205859  probable low-specificity L-threonine aldolase 1 isoform X2 [KO:K01620] [EC:4.1.2.48]
116406341  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
116406343  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
101215910  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
101222345  serine hydroxymethyltransferase 2, mitochondrial [KO:K00600] [EC:2.1.2.1]
101215287  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
101212892  serine hydroxymethyltransferase 3, chloroplastic [KO:K00600] [EC:2.1.2.1]
101211272  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
101222240  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
101217893  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
101207975  serine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
101209132  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
101209989  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
101220201  hydroxyphenylpyruvate reductase [KO:K15919] [EC:1.1.1.79 1.1.1.81]
101208766  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
101215497  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
101215727  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
101211372  uncharacterized protein LOC101211372 [KO:K01834] [EC:5.4.2.11]
101211596  uncharacterized protein LOC101211596 isoform X3 [KO:K01834] [EC:5.4.2.11]
101209304  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
101217925  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
101222060  D-glycerate 3-kinase, chloroplastic isoform X2 [KO:K15918] [EC:2.7.1.31]
101221689  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101219910  LOW QUALITY PROTEIN: D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
116405524  LOW QUALITY PROTEIN: D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
101202934  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
101208305  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
101204200  uncharacterized protein LOC101204200 isoform X1 [KO:K00276] [EC:1.4.3.21]
101213059  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
101222468  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
101210998  primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
101222232  primary amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
101212818  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
101221992  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
101217746  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
101209820  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
101222823  leghemoglobin reductase [KO:K00382] [EC:1.8.1.4]
101207718  dihydrolipoyl dehydrogenase, mitochondrial isoform X1 [KO:K00382] [EC:1.8.1.4]
101209306  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
101217522  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
101222346  glycine cleavage system H protein 3, mitochondrial [KO:K02437]
101210304  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
101203709  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
101208662  LOW QUALITY PROTEIN: alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
116403551  LOW QUALITY PROTEIN: alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
101207914  glutamate--glyoxylate aminotransferase 2 isoform X1 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
101220645  LOW QUALITY PROTEIN: glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
101213570  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
101222314  choline monooxygenase, chloroplastic isoform X1 [KO:K00499] [EC:1.14.15.7]
101213657  betaine aldehyde dehydrogenase 1, chloroplastic [KO:K00130] [EC:1.2.1.8]
101205436  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
101211572  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
101205446  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
101205445  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
101205680  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
101205909  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
101217208  serine racemase [KO:K12235] [EC:5.1.1.18]
101216967  serine racemase [KO:K12235] [EC:5.1.1.18]
101220215  tryptophan synthase alpha chain isoform X1 [KO:K01695] [EC:4.2.1.20]
101222321  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
101208895  tryptophan synthase beta chain 2, chloroplastic [KO:K01696] [EC:4.2.1.20]
101218187  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
101220286  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
101219640  uncharacterized protein LOC101219640 [KO:K06001] [EC:4.2.1.20]
101219882  uncharacterized protein LOC101219882 isoform X1 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
csv00010  Glycolysis / Gluconeogenesis
csv00020  Citrate cycle (TCA cycle)
csv00230  Purine metabolism
csv00250  Alanine, aspartate and glutamate metabolism
csv00270  Cysteine and methionine metabolism
csv00290  Valine, leucine and isoleucine biosynthesis
csv00300  Lysine biosynthesis
csv00330  Arginine and proline metabolism
csv00460  Cyanoamino acid metabolism
csv00470  D-Amino acid metabolism
csv00564  Glycerophospholipid metabolism
csv00600  Sphingolipid metabolism
csv00620  Pyruvate metabolism
csv00630  Glyoxylate and dicarboxylate metabolism
csv00640  Propanoate metabolism
csv00860  Porphyrin metabolism
csv00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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