KEGG   PATHWAY: dle03015
Entry
dle03015                    Pathway                                
Name
mRNA surveillance pathway - Delphinapterus leucas (beluga whale)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
dle03015  mRNA surveillance pathway
dle03015

Other DBs
GO: 0071028
Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111187941  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
111172329  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
111165798  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
111176352  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
111169057  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
111179934  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
111175831  MAGOH; protein mago nashi homolog [KO:K12877]
111176760  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
111166326  CASC3; protein CASC3 [KO:K14323]
111182734  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
111175156  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
111173209  PNN; pinin [KO:K13114]
111164099  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
111185189  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
111182691  ALYREF; THO complex subunit 4 [KO:K12881]
111179527  DDX19B; ATP-dependent RNA helicase DDX19B isoform X1 [KO:K18655] [EC:5.6.2.7]
111177159  GLE1; nucleoporin GLE1 isoform X1 [KO:K18723]
111171143  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
111170887  NXF3; nuclear RNA export factor 3 [KO:K14284]
111183845  NXF1; nuclear RNA export factor 1 [KO:K14284]
111185042  NXT1; NTF2-related export protein 1 isoform X1 [KO:K14285]
111165779  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
111170655  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
111173898  PYM1; partner of Y14 and mago [KO:K14294]
111163224  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
111163638  RNGTT; mRNA-capping enzyme [KO:K13917] [EC:2.7.7.50 3.6.1.74]
111163003  RNMT; mRNA cap guanine-N7 methyltransferase [KO:K00565] [EC:2.1.1.56]
111182109  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
111187116  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
111179339  PABPN1L; embryonic polyadenylate-binding protein 2 isoform X1 [KO:K14396]
111164107  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
111165338  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
111183890  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X1 [KO:K14398]
111173758  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
111170353  PAPOLB; LOW QUALITY PROTEIN: poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
111186609  PAPOLG; poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
111176102  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
111183935  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 isoform X1 [KO:K14399] [EC:2.7.1.78]
111184925  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
111165074  CPSF1; cleavage and polyadenylation specificity factor subunit 1 isoform X1 [KO:K14401]
111165075  cleavage and polyadenylation specificity factor subunit 1-like isoform X1 [KO:K14401]
111176149  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
111164461  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403] [EC:3.1.27.-]
111182880  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
111181918  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
111169735  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
111183344  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
111174316  WDR82; WD repeat-containing protein 82 [KO:K14962]
111174925  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111186906  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
111183676  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
111187090  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform X1 [KO:K15544] [EC:3.1.3.16]
111186641  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
111172542  CSTF2T; cleavage stimulation factor subunit 2 tau variant isoform X1 [KO:K14407]
111178240  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
111179796  CSTF3; cleavage stimulation factor subunit 3 isoform X1 [KO:K14408]
111180721  SYMPK; symplekin [KO:K06100]
111170465  DAZAP1; DAZ-associated protein 1 isoform X1 [KO:K14411]
111162778  MSI1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
111163690  MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
111165903  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
111169266  LOW QUALITY PROTEIN: polyadenylate-binding protein 4-like [KO:K13126]
111178167  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
111171014  polyadenylate-binding protein 1-like 2 [KO:K13126]
111175629  PABPC4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
111184143  polyadenylate-binding protein 1-like [KO:K13126]
111184272  polyadenylate-binding protein 1-like [KO:K13126]
111180377  PABPC1; polyadenylate-binding protein 1 [KO:K13126]
111182504  ETF1; eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
111170771  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
111163470  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
111166517  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
111178000  UPF2; regulator of nonsense transcripts 2 [KO:K14327]
111163541  SMG1; serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
111184638  SMG7; protein SMG7 isoform X1 [KO:K14409]
111167119  SMG5; protein SMG5 isoform X1 [KO:K11125]
111185864  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
111173481  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
111182447  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111168062  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
111181079  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
111179116  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
111183056  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
111185417  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
111172180  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
111168265  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
111179211  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
111173231  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
111183787  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
111176064  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
111184699  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
111173081  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
111178838  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
111166013  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
111186815  PELO; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
dle03013  Nucleocytoplasmic transport
dle03018  RNA degradation
dle03040  Spliceosome
KO pathway
ko03015   
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