KEGG   PATHWAY: dre00053
Entry
dre00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Danio rerio (zebrafish)
Class
Metabolism; Carbohydrate metabolism
Pathway map
dre00053  Ascorbate and aldarate metabolism
dre00053

Other DBs
GO: 0019852 0019577 0019572
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
116991  ugdh; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
569254  gkup; glucuronokinase with putative uridyl pyrophosphorylase [KO:K16190] [EC:2.7.1.43]
406731  ugt1ab; UDP glucuronosyltransferase 1 family a, b precursor [KO:K00699] [EC:2.4.1.17]
570913  ugt5g1; UDP glucuronosyltransferase 5 family, polypeptide G1 precursor [KO:K00699] [EC:2.4.1.17]
553952  ugt2a2; UDP-glucuronosyltransferase 2A2 precursor [KO:K00699] [EC:2.4.1.17]
641488  ugt1a1; UDP-glucuronosyltransferase 1-1 precursor [KO:K00699] [EC:2.4.1.17]
767705  ugt2a5; UDP glucuronosyltransferase 2 family, polypeptide A5 precursor [KO:K00699] [EC:2.4.1.17]
100006320  ugt2a1; UDP-glucuronosyltransferase 2A1 precursor [KO:K00699] [EC:2.4.1.17]
100415797  ugt5a5; UDP glucuronosyltransferase 5 family, polypeptide A5 precursor [KO:K00699] [EC:2.4.1.17]
767756  ugt5a2; UDP glucuronosyltransferase 5 family, polypeptide A2 precursor [KO:K00699] [EC:2.4.1.17]
100415798  ugt5a4; UDP glucuronosyltransferase 5 family, polypeptide A4 precursor [KO:K00699] [EC:2.4.1.17]
100415799  ugt5b2; UDP glucuronosyltransferase 5 family, polypeptide B2 precursor [KO:K00699] [EC:2.4.1.17]
556049  ugt5g2; UDP glucuronosyltransferase 5 family, polypeptide G2 precursor [KO:K00699] [EC:2.4.1.17]
100379286  ugt1a2; UDP glucuronosyltransferase 1 family, polypeptide A2 precursor [KO:K00699] [EC:2.4.1.17]
322378  ugt5a3; UDP glucuronosyltransferase 5 family, polypeptide A3 precursor [KO:K00699] [EC:2.4.1.17]
792506  ugt2b6; UDP glucuronosyltransferase 2 family, polypeptide B6 precursor [KO:K00699] [EC:2.4.1.17]
795050  ugt1b4; UDP glucuronosyltransferase 1 family, polypeptide B4 [KO:K00699] [EC:2.4.1.17]
791613  ugt2a4; UDP glucuronosyltransferase 2 family, polypeptide A4 precursor [KO:K00699] [EC:2.4.1.17]
797211  ugt2a6; UDP glucuronosyltransferase 2 family, polypeptide A6 precursor [KO:K00699] [EC:2.4.1.17]
100002993  ugt5e1; UDP glucuronosyltransferase 5 family, polypeptide E1 precursor [KO:K00699] [EC:2.4.1.17]
751669  ugt5c2; UDP glucuronosyltransferase 5 family, polypeptide C2 [KO:K00699] [EC:2.4.1.17]
100384893  ugt1b2; UDP glucuronosyltransferase 1 family, polypeptide B2 precursor [KO:K00699] [EC:2.4.1.17]
100384896  ugt1a6; UDP-glucuronosyltransferase 1-6 precursor [KO:K00699] [EC:2.4.1.17]
100384891  ugt1a7; UDP-glucuronosyltransferase 1-7 precursor [KO:K00699] [EC:2.4.1.17]
100384895  ugt2b1; UDP glucuronosyltransferase 2 family, polypeptide B1 precursor [KO:K00699] [EC:2.4.1.17]
100384897  ugt1a5; UDP-glucuronosyltransferase 1-5 precursor [KO:K00699] [EC:2.4.1.17]
100384898  ugt2b3; UDP glucuronosyltransferase 2 family, polypeptide B3 isoform 2 precursor [KO:K00699] [EC:2.4.1.17]
100384901  ugt1a4; UDP-glucuronosyltransferase 1-4 precursor [KO:K00699] [EC:2.4.1.17]
100384902  ugt2b5; UDP glucuronosyltransferase 2 family, polypeptide B5 precursor [KO:K00699] [EC:2.4.1.17]
100384903  ugt1b3; UDP glucuronosyltransferase 1 family, polypeptide B3 precursor [KO:K00699] [EC:2.4.1.17]
100415791  ugt5b1; UDP glucuronosyltransferase 5 family, polypeptide B1 precursor [KO:K00699] [EC:2.4.1.17]
100415792  ugt5b3; UDP glucuronosyltransferase 5 family, polypeptide B3 precursor [KO:K00699] [EC:2.4.1.17]
100415794  ugt5d1; UDP glucuronosyltransferase 5 family, polypeptide D1 [KO:K00699] [EC:2.4.1.17]
100415800  ugt5f1; UDP glucuronosyltransferase 5 family, polypeptide F1 precursor [KO:K00699] [EC:2.4.1.17]
100384899  ugt1b5; UDP glucuronosyltransferase 1 family, polypeptide B5 [KO:K00699] [EC:2.4.1.17]
641479  ugt5a1; UDP glucuronosyltransferase 5 family, polypeptide A1 precursor [KO:K00699] [EC:2.4.1.17]
678597  ugt5b6; UDP glucuronosyltransferase 5 family, polypeptide B6 precursor [KO:K00699] [EC:2.4.1.17]
558508  ugt1b1; UDP glucuronosyltransferase 1 family, polypeptide B1 precursor [KO:K00699] [EC:2.4.1.17]
791210  ugt5b4; UDP glucuronosyltransferase 5 family, polypeptide B4 precursor [KO:K00699] [EC:2.4.1.17]
795261  ugt1b7; UDP glucuronosyltransferase 1 family, polypeptide B7 precursor [KO:K00699] [EC:2.4.1.17]
571441  gusb; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
562316  kl; klotho [KO:K14756] [EC:3.2.1.31]
571850  miox; inositol oxygenase [KO:K00469] [EC:1.13.99.1]
799805  akr1a1b; aldo-keto reductase family 1 member A1-B [KO:K00002] [EC:1.1.1.2]
445326  akr1a1a; aldo-keto reductase family 1 member A1-A [KO:K00002] [EC:1.1.1.2]
403070  rgn; regucalcin [KO:K01053] [EC:3.1.1.17]
323653  aldh3a2a; aldehyde dehydrogenase family 3 member A2a [KO:K00128] [EC:1.2.1.3]
393462  aldh2.1; aldehyde dehydrogenase 2 family member, tandem duplicate 1 [KO:K00128] [EC:1.2.1.3]
368239  aldh2.2; aldehyde dehydrogenase 2 family member, tandem duplicate 2 [KO:K00128] [EC:1.2.1.3]
100000026  aldh3a1; fatty aldehyde dehydrogenase isoform X2 [KO:K00128] [EC:1.2.1.3]
492710  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
447920  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
100536795  wu:fb14d09; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
334197  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100005587  aldh9a1a.1; 4-trimethylaminobutyraldehyde dehydrogenase A [KO:K00149] [EC:1.2.1.47 1.2.1.3]
399481  aldh9a1b; 4-trimethylaminobutyraldehyde dehydrogenase B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
100006238  aldh9a1a.2; aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 2 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
dre00020  Citrate cycle (TCA cycle)
dre00040  Pentose and glucuronate interconversions
dre00051  Fructose and mannose metabolism
dre00520  Amino sugar and nucleotide sugar metabolism
dre00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

DBGET integrated database retrieval system