KEGG   PATHWAY: dre00630
Entry
dre00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Danio rerio (zebrafish)
Class
Metabolism; Carbohydrate metabolism
Pathway map
dre00630  Glyoxylate and dicarboxylate metabolism
dre00630

Module
dre_M00621  Glycine cleavage system [PATH:dre00630]
dre_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:dre00630]
Other DBs
GO: 0046487 0043648
Organism
Danio rerio (zebrafish) [GN:dre]
Gene
100000775  glula; glutamate-ammonia ligase (glutamine synthase) a [KO:K01915] [EC:6.3.1.2]
100144628  shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
30068  cat; catalase [KO:K03781] [EC:1.11.1.6]
30643  acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
321621  gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
322339  cs; citrate synthase, mitochondrial precursor [KO:K01647] [EC:2.3.3.1]
322670  aco2; aconitate hydratase, mitochondrial [KO:K01681] [EC:4.2.1.3]
335715  mdh1ab; malate dehydrogenase 1Ab, NAD (soluble) isoform mdh1x [KO:K00025] [EC:1.1.1.37]
336473  glulb; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
393305  hyi; putative hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
393455  hao2; 2-Hydroxyacid oxidase 2 [KO:K11517] [EC:1.1.3.15]
394021  shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
399479  dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
399662  mdh1aa; malate dehydrogenase 1Aa, NAD (soluble) isoform 2 precursor [KO:K00025] [EC:1.1.1.37]
402827  hao1; 2-Hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
402985  grhprb; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
405806  hoga1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor [KO:K18123] [EC:4.1.3.16]
405861  pccb; propionyl-CoA carboxylase beta chain, mitochondrial [KO:K01966] [EC:6.4.1.3 2.1.3.15]
406405  mdh2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
436603  agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
436852  gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]
436914  acss2; acetyl-coenzyme A synthetase, cytoplasmic [KO:K01895] [EC:6.2.1.1]
437019  pcca; propionyl-CoA carboxylase alpha chain, mitochondrial [KO:K01965] [EC:6.4.1.3]
445290  acat1; acetyl-CoA acetyltransferase, mitochondrial precursor [KO:K00626] [EC:2.3.1.9]
450000  amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
497183  grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]
541329  gcsha; glycine cleavage system protein H (aminomethyl carrier), a [KO:K02437]
541435  acss1; acetyl-coenzyme A synthetase 2-like, mitochondrial [KO:K01895] [EC:6.2.1.1]
550372  afmid; kynurenine formamidase [KO:K01432] [EC:3.5.1.9]
553804  mcee; methylmalonyl-CoA epimerase, mitochondrial [KO:K05606] [EC:5.1.99.1]
560020  acss2l; acyl-CoA synthetase short chain family member 2 like [KO:K01895] [EC:6.2.1.1]
566165  glulc; glutamate-ammonia ligase (glutamine synthase) c [KO:K01915] [EC:6.3.1.2]
568448  aco1; cytoplasmic aconitate hydratase [KO:K01681] [EC:4.2.1.3]
569581  mmut; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
570678  glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]
619269  agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
792824  pgp; glycerol-3-phosphate phosphatase [KO:K19269] [EC:3.1.3.18 3.1.3.48]
79378  agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
dre00010  Glycolysis / Gluconeogenesis
dre00020  Citrate cycle (TCA cycle)
dre00030  Pentose phosphate pathway
dre00053  Ascorbate and aldarate metabolism
dre00071  Fatty acid degradation
dre00230  Purine metabolism
dre00250  Alanine, aspartate and glutamate metabolism
dre00260  Glycine, serine and threonine metabolism
dre00270  Cysteine and methionine metabolism
dre00620  Pyruvate metabolism
dre00750  Vitamin B6 metabolism
dre00910  Nitrogen metabolism
KO pathway
ko00630   

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