KEGG   PATHWAY: efus03015
Entry
efus03015                   Pathway                                
Name
mRNA surveillance pathway - Eptesicus fuscus (big brown bat)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
efus03015  mRNA surveillance pathway
efus03015

Other DBs
GO: 0071028
Organism
Eptesicus fuscus (big brown bat) [GN:efus]
Gene
103286407  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
103303538  NCBP2; nuclear cap-binding protein subunit 2 isoform X2 [KO:K12883]
129150641  NCBP2L; nuclear cap-binding protein subunit 2-like [KO:K12883]
103288297  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
103299982  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
103296532  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
103284007  MAGOH; protein mago nashi homolog [KO:K12877]
103285088  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
103288988  CASC3; protein CASC3 [KO:K14323]
103298370  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
103304102  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
103303808  PNN; pinin isoform X1 [KO:K13114]
103301518  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
103290513  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X2 [KO:K14325]
103298348  ALYREF; THO complex subunit 4 [KO:K12881]
103284655  DDX19A; ATP-dependent RNA helicase DDX19A isoform X3 [KO:K18655] [EC:5.6.2.7]
103284656  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
103296047  GLE1; mRNA export factor GLE1 [KO:K18723]
103303729  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
103299724  nuclear RNA export factor 2 [KO:K14284]
103302184  NXF3; nuclear RNA export factor 3 [KO:K14284]
103302189  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
103299725  nuclear RNA export factor 2-like [KO:K14284]
103285718  NXT1; NTF2-related export protein 1 [KO:K14285]
103288242  NTF2-related export protein 1-like [KO:K14285]
103288954  NTF2-related export protein 1-like [KO:K14285]
103303099  NXT2; NTF2-related export protein 2 [KO:K14285]
103300482  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
103292402  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
103291939  SRRM1; serine/arginine repetitive matrix protein 1 isoform X5 [KO:K13171]
103291791  RNGTT; mRNA-capping enzyme isoform X4 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
103302496  RNMT; mRNA cap guanine-N7 methyltransferase isoform X1 [KO:K00565] [EC:2.1.1.56]
103296231  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
103295415  TARDBP; TAR DNA-binding protein 43 isoform X1 [KO:K23600]
103301511  polyadenylate-binding protein 2 isoform X1 [KO:K14396]
103284753  PABPN1L; LOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2 [KO:K14396]
103295846  NUDT21; cleavage and polyadenylation specificity factor subunit 5 isoform X1 [KO:K14397]
103303321  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X2 [KO:K14398]
103292571  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
103298050  PAPOLA; poly(A) polymerase alpha isoform X3 [KO:K14376] [EC:2.7.7.19]
103299171  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
103305379  PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
103302287  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
103293644  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X2 [KO:K14400]
103302640  CPSF1; cleavage and polyadenylation specificity factor subunit 1 isoform X3 [KO:K14401]
103292245  CPSF2; cleavage and polyadenylation specificity factor subunit 2 isoform X1 [KO:K14402]
103305601  CPSF3; cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
103285962  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X4 [KO:K14404]
103299437  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
103284965  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X2 [KO:K14405]
103301212  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
103295186  WDR82; WD repeat-containing protein 82 [KO:K14962]
103287049  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
103290927  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103297381  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like isoform X2 [KO:K06269] [EC:3.1.3.16]
103305499  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103295272  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
103301722  LOW QUALITY PROTEIN: RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like [KO:K15544] [EC:3.1.3.16]
103296796  RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like [KO:K15544] [EC:3.1.3.16]
103285765  CSTF1; cleavage stimulation factor subunit 1 isoform X1 [KO:K14406]
103296370  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
103299698  CSTF2; cleavage stimulation factor subunit 2 [KO:K14407]
103291045  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
103301373  SYMPK; symplekin [KO:K06100]
103291659  MSI2; RNA-binding protein Musashi homolog 2 isoform X2 [KO:K14411]
103294294  DAZAP1; DAZ-associated protein 1 isoform X3 [KO:K14411]
103287255  MSI1; RNA-binding protein Musashi homolog 1 [KO:K14411]
103290366  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
103294762  PABPC4; polyadenylate-binding protein 4 isoform X4 [KO:K13126]
103302424  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
103304072  PABPC1L; polyadenylate-binding protein 1-like [KO:K13126]
114229477  polyadenylate-binding protein 1-like 2 [KO:K13126]
103304084  polyadenylate-binding protein 1-like 2 [KO:K13126]
103292309  PABPC1; polyadenylate-binding protein 1 isoform X1 [KO:K13126]
129148067  LOW QUALITY PROTEIN: polyadenylate-binding protein 1-like [KO:K13126]
103299738  LOW QUALITY PROTEIN: polyadenylate-binding protein 1-like [KO:K13126]
103289615  LOW QUALITY PROTEIN: eukaryotic peptide chain release factor subunit 1-like [KO:K03265]
103289916  ETF1; eukaryotic peptide chain release factor subunit 1 isoform X1 [KO:K03265]
103286107  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
103301312  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
103299528  UPF1; regulator of nonsense transcripts 1 isoform X2 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
103294021  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
103286080  SMG1; serine/threonine-protein kinase SMG1 [KO:K08873] [EC:2.7.11.1]
103290018  SMG7; nonsense-mediated mRNA decay factor SMG7 isoform X3 [KO:K14409]
103298867  SMG5; nonsense-mediated mRNA decay factor SMG5 [KO:K11125]
103291776  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
103286718  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
103290347  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
103293769  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
103304255  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
103285340  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
103295052  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
103288691  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X3 [KO:K04354]
103294548  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
103301982  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
103296345  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
103304576  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
103283666  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
103290054  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
103296652  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
103298034  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
103302063  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
103305428  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
103298068  PELO; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
efus03013  Nucleocytoplasmic transport
efus03018  RNA degradation
efus03040  Spliceosome
KO pathway
ko03015   
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