KEGG   PATHWAY: erp00260
Entry
erp00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Erwinia rhapontici
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
erp00260  Glycine, serine and threonine metabolism
erp00260

Module
erp_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:erp00260]
erp_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:erp00260]
erp_M00555  Betaine biosynthesis, choline => betaine [PATH:erp00260]
erp_M00621  Glycine cleavage system [PATH:erp00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Erwinia rhapontici [GN:erp]
Gene
LJN55_21580  lysC; lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
LJN55_19765  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
LJN55_22360  bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
LJN55_01630  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
LJN55_19760  thrB; homoserine kinase [KO:K00872] [EC:2.7.1.39]
LJN55_19755  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
LJN55_07360  ltaE; low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
LJN55_17385  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LJN55_09575  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
LJN55_13655  ghrA; glyoxylate/hydroxypyruvate reductase GhrA [KO:K12972] [EC:1.1.1.79 1.1.1.81]
LJN55_00075  ghrB; glyoxylate/hydroxypyruvate reductase GhrB [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
LJN55_09225  glycerate kinase [KO:K00865] [EC:2.7.1.165]
LJN55_06575  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
LJN55_19795  gpmB; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase GpmB [KO:K15634] [EC:5.4.2.11]
LJN55_04320  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LJN55_11760  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LJN55_07485  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
LJN55_19895  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
LJN55_10930  ydfG; bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG [KO:K16066] [EC:1.1.1.381 1.1.1.-]
LJN55_22815  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
LJN55_22810  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
LJN55_04370  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
LJN55_04360  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
LJN55_19205  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LJN55_04365  gcvH; glycine cleavage system protein GcvH [KO:K02437]
LJN55_17730  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
LJN55_01300  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
LJN55_10710  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
LJN55_01295  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LJN55_10705  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LJN55_13120  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
LJN55_22215  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
LJN55_09380  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
LJN55_04595  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
LJN55_12245  D-serine ammonia-lyase [KO:K01753] [EC:4.3.1.18]
LJN55_12760  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
LJN55_12755  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
LJN55_03330  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
LJN55_03335  aspartate aminotransferase family protein [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
erp00010  Glycolysis / Gluconeogenesis
erp00020  Citrate cycle (TCA cycle)
erp00230  Purine metabolism
erp00250  Alanine, aspartate and glutamate metabolism
erp00270  Cysteine and methionine metabolism
erp00290  Valine, leucine and isoleucine biosynthesis
erp00300  Lysine biosynthesis
erp00330  Arginine and proline metabolism
erp00460  Cyanoamino acid metabolism
erp00470  D-Amino acid metabolism
erp00564  Glycerophospholipid metabolism
erp00600  Sphingolipid metabolism
erp00620  Pyruvate metabolism
erp00630  Glyoxylate and dicarboxylate metabolism
erp00640  Propanoate metabolism
erp00680  Methane metabolism
erp00860  Porphyrin metabolism
erp00920  Sulfur metabolism
KO pathway
ko00260   
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