KEGG   PATHWAY: ete00020
Entry
ete00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Edwardsiella anguillarum
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
ete00020  Citrate cycle (TCA cycle)
ete00020

Module
ete_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:ete00020]
ete_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:ete00020]
ete_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:ete00020]
ete_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:ete00020]
ete_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:ete00020]
Other DBs
GO: 0006099
Organism
Edwardsiella anguillarum [GN:ete]
Gene
ETEE_0686  gltA; Citrate synthase (si) [KO:K01647] [EC:2.3.3.1]
ETEE_2431  acnB; Aconitate hydratase 2 [KO:K01682] [EC:4.2.1.3 4.2.1.99]
ETEE_0038  icd; Isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
ETEE_0680  sucA; 2-oxoglutarate dehydrogenase E1 component [KO:K00164] [EC:1.2.4.2]
ETEE_0679  sucB; Dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex [KO:K00658] [EC:2.3.1.61]
ETEE_1697  lpd; Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
ETEE_2429  Glutathione reductase [KO:K00382] [EC:1.8.1.4]
ETEE_0677  sucD; Succinyl-CoA ligase [ADP-forming] alpha chain [KO:K01902] [EC:6.2.1.5]
ETEE_0678  sucC; Succinyl-CoA ligase [ADP-forming] beta chain [KO:K01903] [EC:6.2.1.5]
ETEE_0682  sdhA; Succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
ETEE_0681  sdhB; Succinate dehydrogenase iron-sulfur protein [KO:K00240] [EC:1.3.5.1]
ETEE_0684  sdhC; Succinate dehydrogenase cytochrome b-556 subunit [KO:K00241]
ETEE_0683  sdhD; Succinate dehydrogenase hydrophobic membrane anchor protein [KO:K00242]
ETEE_2095  frdA; Succinate dehydrogenase flavoprotein subunit [KO:K00244] [EC:1.3.5.1]
ETEE_2094  frdB; Succinate dehydrogenase iron-sulfur protein [KO:K00245] [EC:1.3.5.1]
ETEE_2093  frdC; fumarate reductase subunit C protein [KO:K00246]
ETEE_2092  frdD; fumarate reductase subunit D [KO:K00247]
ETEE_0108  fumA; Fumarate hydratase class I, aerobic [KO:K01676] [EC:4.2.1.2]
ETEE_3607  fumC; Fumarate hydratase class II [KO:K01679] [EC:4.2.1.2]
ETEE_3756  fumC; Fumarate hydratase class II [KO:K01679] [EC:4.2.1.2]
ETEE_2145  mdh; Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
ETEE_1505  pckA; Phosphoenolpyruvate carboxykinase [ATP] [KO:K01610] [EC:4.1.1.49]
ETEE_2427  aceE; Pyruvate dehydrogenase E1 component [KO:K00163] [EC:1.2.4.1]
ETEE_2428  aceF; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex [KO:K00627] [EC:2.3.1.12]
ETEE_0585  nifJ; Pyruvate-flavodoxin oxidoreductase [KO:K03737] [EC:1.2.7.1 1.2.7.-]
ETEE_3824  nifJ; Pyruvate-flavodoxin oxidoreductase [KO:K03737] [EC:1.2.7.1 1.2.7.-]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
ete00010  Glycolysis / Gluconeogenesis
ete00053  Ascorbate and aldarate metabolism
ete00061  Fatty acid biosynthesis
ete00071  Fatty acid degradation
ete00190  Oxidative phosphorylation
ete00220  Arginine biosynthesis
ete00250  Alanine, aspartate and glutamate metabolism
ete00280  Valine, leucine and isoleucine degradation
ete00350  Tyrosine metabolism
ete00470  D-Amino acid metabolism
ete00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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