KEGG   PATHWAY: etw00630
Entry
etw00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Escherichia coli O157:H7 TW14359 (EHEC)
Class
Metabolism; Carbohydrate metabolism
Pathway map
etw00630  Glyoxylate and dicarboxylate metabolism
etw00630

Module
etw_M00012  Glyoxylate cycle [PATH:etw00630]
etw_M00621  Glycine cleavage system [PATH:etw00630]
Other DBs
GO: 0046487 0043648
Organism
Escherichia coli O157:H7 TW14359 (EHEC) [GN:etw]
Gene
ECSP_5084  aceA; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
ECSP_5166  acs; acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
ECSP_5083  aceB; malate synthase A [KO:K01638] [EC:2.3.3.9]
ECSP_4205  mdh; malate dehydrogenase, NAD(P)-binding [KO:K00024] [EC:1.1.1.37]
ECSP_0762  gltA; citrate synthase [KO:K01647] [EC:2.3.3.1]
ECSP_1796  acnA; aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
ECSP_0824  ybhJ; predicted hydratase [KO:K01681] [EC:4.2.1.3]
ECSP_0119  acnB; bifunctional aconitate hydratase 2 [KO:K01682] [EC:4.2.1.3 4.2.1.99]
ECSP_3797  yqeF; predicted acyltransferase [KO:K00626] [EC:2.3.1.9]
ECSP_3883  sbm; methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
ECSP_0780  putative glutamate mutase subumit E [KO:K19268] [EC:5.4.99.1]
ECSP_0782  putative glutamate mutase subumit S [KO:K01846] [EC:5.4.99.1]
ECSP_0779  putative methylaspartate ammonia-lyase [KO:K04835] [EC:4.3.1.2]
ECSP_2300  katE; hydroperoxidase HPII(III) (catalase) [KO:K03781] [EC:1.11.1.6]
ECSP_1334  ycdW; 2-ketoacid reductase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
ECSP_4549  ghrB; 2-keto-D-gluconate reductase (glyoxalate reductase) (2-ketoaldonate reductase) [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
ECSP_4334  gph; phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
ECSP_4925  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
ECSP_3495  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
ECSP_3870  gcvP; glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
ECSP_3872  gcvT; aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex [KO:K00605] [EC:2.1.2.10]
ECSP_0117  lpd; lipoamide dehydrogenase, E3 component is part of three enzyme complexes [KO:K00382] [EC:1.8.1.4]
ECSP_3871  gcvH; glycine cleavage complex lipoylprotein [KO:K02437]
ECSP_0582  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
ECSP_0583  hyi; hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
ECSP_0584  glxR; tartronate semialdehyde reductase, NADH-dependent [KO:K00042] [EC:1.1.1.60]
ECSP_4096  garR; tartronate semialdehyde reductase [KO:K00042] [EC:1.1.1.60]
ECSP_0588  glxK; glycerate kinase II [KO:K00865] [EC:2.7.1.165]
ECSP_4095  garK; glycerate kinase I [KO:K00865] [EC:2.7.1.165]
ECSP_1897  aldA; aldehyde dehydrogenase A, NAD-linked [KO:K07248] [EC:1.2.1.22 1.2.1.21]
ECSP_3751  fucO; L-1,2-propanediol oxidoreductase [KO:K00048] [EC:1.1.1.77]
ECSP_4034  ttdA; L-tartrate dehydratase, alpha subunit [KO:K03779] [EC:4.2.1.32]
ECSP_4035  ttdB; L-tartrate dehydratase, beta subunit [KO:K03780] [EC:4.2.1.32]
ECSP_2372  yeaU; predicted dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
ECSP_2424  eda; 2-dehydro-3-deoxyphosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
ECSP_4952  fdoG; formate dehydrogenase-O, large subunit [KO:K00123] [EC:1.17.1.9]
ECSP_4953  formate dehydrogenase-O, large subunit [KO:K00123] [EC:1.17.1.9]
ECSP_4951  fdoH; formate dehydrogenase-O, Fe-S subunit [KO:K00124]
ECSP_4950  fdoI; formate dehydrogenase-O, cytochrome b556 subunit [KO:K00127]
ECSP_1624  purU; formyltetrahydrofolate hydrolase [KO:K01433] [EC:3.5.1.10]
ECSP_3322  oxc; predicted oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
ECSP_3323  frc; formyl-CoA transferase, NAD(P)-binding [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
etw00010  Glycolysis / Gluconeogenesis
etw00020  Citrate cycle (TCA cycle)
etw00030  Pentose phosphate pathway
etw00053  Ascorbate and aldarate metabolism
etw00071  Fatty acid degradation
etw00230  Purine metabolism
etw00250  Alanine, aspartate and glutamate metabolism
etw00260  Glycine, serine and threonine metabolism
etw00620  Pyruvate metabolism
etw00710  Carbon fixation by Calvin cycle
etw00750  Vitamin B6 metabolism
etw00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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