KEGG   PATHWAY: gab00480
Entry
gab00480                    Pathway                                
Name
Glutathione metabolism - Gossypium arboreum (tree cotton)
Class
Metabolism; Metabolism of other amino acids
Pathway map
gab00480  Glutathione metabolism
gab00480

Module
gab_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:gab00480]
Other DBs
GO: 0006749
Organism
Gossypium arboreum (tree cotton) [GN:gab]
Gene
108479337  gamma-glutamyltranspeptidase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
108484181  gamma-glutamyltranspeptidase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
108465475  gamma-glutamyltranspeptidase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
108466564  gamma-glutamyltranspeptidase 1-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
108470497  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
108484627  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
108485529  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
108475460  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
108457276  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
108470560  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
108486472  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
108485078  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
108464252  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
108483141  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
108468385  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
108488496  glutathione S-transferase U23-like isoform X1 [KO:K00799] [EC:2.5.1.18]
108473920  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
108469686  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
108475564  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
108475580  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
108475599  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108475621  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
108473827  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108474893  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
108482878  glutathione S-transferase T1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
108468199  glutathione S-transferase F6-like [KO:K00799] [EC:2.5.1.18]
108472684  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
108471845  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
108475540  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
108475548  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108483039  glutathione S-transferase U1-like [KO:K00799] [EC:2.5.1.18]
108475314  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108482515  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
108468560  glutathione S-transferase U16-like [KO:K00799] [EC:2.5.1.18]
108480247  glutathione S-transferase F8, chloroplastic-like [KO:K00799] [EC:2.5.1.18]
108474729  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108487217  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
108489765  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108454924  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
108468001  glutathione S-transferase T1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
108488022  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
108457951  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
108475671  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108459359  glutathione S-transferase U16-like [KO:K00799] [EC:2.5.1.18]
108459388  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
108484778  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
108464259  glutathione S-transferase L3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
108464573  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108450430  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108454054  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
108454055  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
108454384  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
108462151  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
108461893  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108456230  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108463234  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108463354  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108463395  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
108457477  glutathione S-transferase F6-like [KO:K00799] [EC:2.5.1.18]
108463528  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
108465975  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108466075  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108463191  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
108465640  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
108452836  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
108455731  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
108455969  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
108455985  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
108480636  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
108470682  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
108458125  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
108456914  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
108473553  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
108464396  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
108487334  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
108454073  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial-like [KO:K00031] [EC:1.1.1.42]
108466014  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
108464309  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
108469761  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
108454870  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
108453269  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
108473976  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
108483725  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
108470637  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
108489820  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
108457256  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
108459252  LOW QUALITY PROTEIN: glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
108454063  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
108483627  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
108480705  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
108469873  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
108470156  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
108469951  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
108454306  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
108461590  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
108488386  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
108472403  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
108472568  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
108476249  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
108479281  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
108467433  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
108485211  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
108486104  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
108467585  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
108470238  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
108484599  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
108489681  probable L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
108475956  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
108467715  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
108488538  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
108463433  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
108453402  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
108453752  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
108474030  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
108461317  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
108474478  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
108487296  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
108474256  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
gab00220  Arginine biosynthesis
gab00250  Alanine, aspartate and glutamate metabolism
gab00270  Cysteine and methionine metabolism
gab00430  Taurine and hypotaurine metabolism
gab00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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