KEGG   PATHWAY: gfs04013
Entry
gfs04013                    Pathway                                
Name
MAPK signaling pathway - fly - Glossina fuscipes (tsetse fly)
Description
The mitogen-activated protein kinase (MAPK) signaling cascades that are highly conserved from yeast to mammals use protein phosphorylation to convey signals intracellularly, and play a crucial role in mitosis, apoptosis, motility and metabolism. In fruit fly, three major classes of MAPK pathways have been distinguished with little or no redundancy, including extracellular signal-regulated kinase (ERK) / Rolled, c-Jun N-terminal kinase (JNK) / Bsk, and p38 kinase. Signals from growth factors or mitogens are dominantly transduced by the ERK pathway, whereas the JNK and p38 pathways are activated mostly by environmental stresses. The MAPK signaling cascades are typically linked to regulation of gene expression, because transcription factors are often the targets of regulatory phosphorylation events.
Class
Environmental Information Processing; Signal transduction
Pathway map
gfs04013  MAPK signaling pathway - fly
gfs04013

Other DBs
GO: 0000165
Organism
Glossina fuscipes (tsetse fly) [GN:gfs]
Gene
119638066  torso-like protein isoform X1 [KO:K12377]
119635864  tyrosine-protein kinase receptor torso [KO:K12378] [EC:2.7.10.1]
119645128  protein giant-lens [KO:K02104]
119645151  protein vein isoform X1 [KO:K16690]
119641116  protein spitz-like [KO:K20229]
119633419  protein gurken [KO:K02447]
119631430  protein spitz [KO:K16691]
119636171  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119634126  uncharacterized protein LOC119634126 [KO:K20230]
119639587  protein bride of sevenless isoform X1 [KO:K04623]
119644145  protein sevenless [KO:K05088] [EC:2.7.10.1]
119631470  SHC-transforming protein 1 [KO:K06279]
119636801  growth factor receptor-bound protein 2 [KO:K04364]
119632673  protein daughter of sevenless isoform X1 [KO:K20231]
119632865  tyrosine-protein phosphatase corkscrew-like [KO:K07293] [EC:3.1.3.48]
119633250  tyrosine-protein phosphatase corkscrew-like [KO:K07293] [EC:3.1.3.48]
119640473  protein son of sevenless isoform X1 [KO:K03099]
119645069  protein sprouty [KO:K17383]
119642767  ras-like protein 1 [KO:K07827]
119637147  ras GTPase-activating protein 1-like [KO:K04352]
119631850  GTPase-activating protein [KO:K12380]
119643132  raf homolog serine/threonine-protein kinase Raf [KO:K04365] [EC:2.7.11.1]
119636641  14-3-3 protein zeta isoform X1 [KO:K16197]
119633722  14-3-3 protein zeta-like [KO:K16197]
119633440  serine/threonine-protein phosphatase PP2A [KO:K04382] [EC:3.1.3.16]
119636926  uncharacterized protein LOC119636926 [KO:K17536]
119642640  kinase suppressor of Ras 2 isoform X1 [KO:K18529] [EC:2.7.11.1]
119638140  dual specificity mitogen-activated protein kinase kinase dSOR1 isoform X1 [KO:K04368] [EC:2.7.12.2]
119633046  mitogen-activated protein kinase ERK-A [KO:K04371] [EC:2.7.11.24]
119636393  uncharacterized protein LOC119636393 [KO:K20220] [EC:3.1.3.48]
119631745  importin-7 [KO:K20223]
119639051  LOW QUALITY PROTEIN: putative transcription factor capicua [KO:K20225]
119634558  protein tailless [KO:K08545]
119644202  protein tailless-like [KO:K08545]
119644220  protein tailless-like [KO:K08545]
119638926  protein groucho isoform X1 [KO:K04497]
119638883  adult enhancer factor 1 [KO:K12379]
119634609  ETS-like protein pointed isoform X1 [KO:K02678]
119634201  ets DNA-binding protein pokkuri [KO:K03211]
119636181  dual specificity tyrosine-phosphorylation-regulated kinase 1A [KO:K20232]
119633666  exportin-1 [KO:K14290]
119639619  protein tramtrack, alpha isoform isoform X1 [KO:K09237]
119636543  protein phyllopod [KO:K20233]
119635415  E3 ubiquitin-protein ligase sina-like [KO:K04506] [EC:2.3.2.27]
119632660  E3 ubiquitin-protein ligase sina isoform X1 [KO:K04506] [EC:2.3.2.27]
119633242  F-box-like/WD repeat-containing protein ebi [KO:K04508]
119634585  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
119635944  protein lozenge isoform X1 [KO:K20214]
119636190  protein eiger [KO:K16678]
119644819  tumor necrosis factor receptor superfamily member wengen isoform X1 [KO:K16679]
119635213  uncharacterized protein LOC119635213 [KO:K20234]
119631921  tyrosine-protein kinase Src64B [KO:K05704] [EC:2.7.10.2]
119633258  tyrosine-protein kinase Btk29A isoform X1 [KO:K07364] [EC:2.7.10.2]
119642493  tyrosine-protein kinase Shark [KO:K17512] [EC:2.7.10.2]
119632262  serine/threonine-protein kinase mig-15 isoform X1 [KO:K08840] [EC:2.7.11.1]
119638763  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119631416  ras-related protein Rac1 [KO:K04392]
119639162  ras-like GTP-binding protein RhoL isoform X1 [KO:K04392]
119641147  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119633835  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
119631949  uncharacterized protein LOC119631949 isoform X1 [KO:K04417] [EC:2.7.11.25]
119644768  mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
119634738  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
119638952  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
119642985  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
119632933  striatin-3 isoform X1 [KO:K17608]
119639762  transcription factor AP-1 isoform X1 [KO:K04448]
119635210  transcription factor kayak-like isoform X1 [KO:K09031]
119634055  zinc finger protein 236 isoform X1 [KO:K20210]
119632786  uncharacterized protein LOC119632786 isoform X1 [KO:K20235]
119640659  protein decapentaplegic [KO:K04662]
119633898  profilin [KO:K05759]
119638715  dual specificity protein phosphatase 8 isoform X1 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
119631340  cell death protein hid [KO:K20016]
119639624  bone morphogenetic protein receptor type-1A-like [KO:K13578] [EC:2.7.11.30]
119632942  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
119634683  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
119639363  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
119643226  dual specificity mitogen-activated protein kinase kinase 3-like [KO:K04432] [EC:2.7.12.2]
119631314  dual specificity mitogen-activated protein kinase kinase 3-like [KO:K04432] [EC:2.7.12.2]
119642016  mitogen-activated protein kinase p38a [KO:K04441] [EC:2.7.11.24]
119642322  mitogen-activated protein kinase p38b isoform X1 [KO:K04441] [EC:2.7.11.24]
119642325  dual oxidase [KO:K13411] [EC:1.6.3.1 1.11.1.-]
119643602  optomotor-blind protein [KO:K10176]
119641416  myocyte-specific enhancer factor 2 isoform X1 [KO:K09260]
119636829  superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
Reference
PMID:23732470
  Authors
Sopko R, Perrimon N
  Title
Receptor tyrosine kinases in Drosophila development.
  Journal
Cold Spring Harb Perspect Biol 5:a009050 (2013)
DOI:10.1101/cshperspect.a009050
Reference
PMID:15704136
  Authors
Li WX
  Title
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development.
  Journal
Dev Dyn 232:656-72 (2005)
DOI:10.1002/dvdy.20295
Reference
PMID:12648473
  Authors
Shilo BZ
  Title
Signaling by the Drosophila epidermal growth factor receptor pathway during development.
  Journal
Exp Cell Res 284:140-9 (2003)
DOI:10.1016/S0014-4827(02)00094-0
Reference
PMID:10771085
  Authors
Raabe T
  Title
The sevenless signaling pathway: variations of a common theme.
  Journal
Biochim Biophys Acta 1496:151-63 (2000)
DOI:10.1016/S0167-4889(00)00020-3
Reference
PMID:23109363
  Authors
Rios-Barrera LD, Riesgo-Escovar JR
  Title
Regulating cell morphogenesis: the Drosophila Jun N-terminal kinase pathway.
  Journal
Genesis 51:147-62 (2013)
DOI:10.1002/dvg.22354
Reference
PMID:24981286
  Authors
Igaki T, Miura M
  Title
The Drosophila TNF ortholog Eiger: emerging physiological roles and evolution of the TNF system.
  Journal
Semin Immunol 26:267-74 (2014)
DOI:10.1016/j.smim.2014.05.003
Reference
PMID:16014325
  Authors
Zhuang ZH, Zhou Y, Yu MC, Silverman N, Ge BX
  Title
Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli.
  Journal
Cell Signal 18:441-8 (2006)
DOI:10.1016/j.cellsig.2005.05.013
Reference
PMID:10557109
  Authors
Stronach BE, Perrimon N
  Title
Stress signaling in Drosophila.
  Journal
Oncogene 18:6172-82 (1999)
DOI:10.1038/sj.onc.1203125
Related
pathway
gfs04214  Apoptosis - fly
KO pathway
ko04013   
LinkDB

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