KEGG   PATHWAY: gsj00260
Entry
gsj00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Glycine soja (wild soybean)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
gsj00260  Glycine, serine and threonine metabolism
gsj00260

Module
gsj_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:gsj00260]
gsj_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:gsj00260]
gsj_M00555  Betaine biosynthesis, choline => betaine [PATH:gsj00260]
gsj_M00621  Glycine cleavage system [PATH:gsj00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Glycine soja (wild soybean) [GN:gsj]
Gene
114400755  aspartokinase 1, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
114388937  aspartokinase 1, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
114382989  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
114390721  aspartokinase 2, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
114421642  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
114412867  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
114413679  uncharacterized protein LOC114413679 [KO:K00133] [EC:1.2.1.11]
114421231  uncharacterized protein LOC114421231 [KO:K00133] [EC:1.2.1.11]
114383697  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
114376879  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
114385711  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
114393075  threonine synthase 1, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
114407737  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
114401308  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
114372306  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
114423034  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
114412881  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
114395743  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
114421648  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
114415361  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
114422266  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
114396330  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
114368937  serine hydroxymethyltransferase, mitochondrial-like isoform X1 [KO:K00600] [EC:2.1.2.1]
114384573  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
114379425  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
114376038  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
114423302  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
114396764  serine--glyoxylate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
114402970  glycerate dehydrogenase HPR, peroxisomal [KO:K15893] [EC:1.1.1.29]
114369623  glycerate dehydrogenase-like [KO:K15893] [EC:1.1.1.29]
114418519  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
114418522  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
114418524  glyoxylate/hydroxypyruvate reductase HPR3-like isoform X1 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
114415341  uncharacterized protein LOC114415341 [KO:K01834] [EC:5.4.2.11]
114424414  uncharacterized protein LOC114424414 isoform X1 [KO:K01834] [EC:5.4.2.11]
114409306  uncharacterized protein LOC114409306 isoform X1 [KO:K01834] [EC:5.4.2.11]
114413132  uncharacterized protein LOC114413132 [KO:K01834] [EC:5.4.2.11]
114381220  uncharacterized protein LOC114381220 [KO:K01834] [EC:5.4.2.11]
114412366  phosphoglycerate mutase-like protein 4 isoform X1 [KO:K15634] [EC:5.4.2.11]
114412367  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
114396118  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
114425287  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
114386362  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
114377266  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
114403457  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
114417885  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
114422535  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
114371249  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
114374605  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
114419293  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
114381016  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
114376268  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
114409667  phosphoserine phosphatase, chloroplastic-like [KO:K01079] [EC:3.1.3.3]
114416619  phosphoserine phosphatase, chloroplastic-like isoform X1 [KO:K01079] [EC:3.1.3.3]
114402241  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
114403012  primary amine oxidase 1-like [KO:K00276] [EC:1.4.3.21]
114402291  primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
114423112  uncharacterized protein LOC114423112 isoform X1 [KO:K00276] [EC:1.4.3.21]
114412254  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
114416416  uncharacterized protein LOC114416416 isoform X1 [KO:K00276] [EC:1.4.3.21]
114402704  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
114395655  uncharacterized protein LOC114395655 [KO:K00276] [EC:1.4.3.21]
114380636  uncharacterized protein LOC114380636 [KO:K00276] [EC:1.4.3.21]
114369567  primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
114387645  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
114393439  uncharacterized protein LOC114393439 isoform X1 [KO:K00276] [EC:1.4.3.21]
114370619  primary amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
114394257  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
114387446  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
114414819  glycine dehydrogenase (decarboxylating), mitochondrial-like isoform X1 [KO:K00281] [EC:1.4.4.2]
114408819  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
114393669  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
114384869  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
114420185  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
114388631  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
114393256  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
114367918  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
114419928  leghemoglobin reductase [KO:K00382] [EC:1.8.1.4]
114419982  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
114392256  leghemoglobin reductase-like [KO:K00382] [EC:1.8.1.4]
114388466  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
114394030  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
114367743  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
114419784  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
114422888  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
114403751  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
114401680  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
114375832  glycine cleavage system H protein, mitochondrial [KO:K02437]
114413150  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
114416718  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
114406010  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
114421900  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
114394510  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
114380838  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
114409594  glutamate--glyoxylate aminotransferase 2-like [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
114380572  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
114393718  choline monooxygenase, chloroplastic isoform X1 [KO:K00499] [EC:1.14.15.7]
114416483  betaine aldehyde dehydrogenase 1, chloroplastic-like [KO:K00130] [EC:1.2.1.8]
114411924  betaine aldehyde dehydrogenase 1, chloroplastic [KO:K00130] [EC:1.2.1.8]
114386830  aldehyde dehydrogenase family 7 member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
114367858  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
114409050  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
114371961  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
114382762  threonine dehydratase biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
114413364  serine racemase-like [KO:K12235] [EC:5.1.1.18]
114406892  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
114397987  tryptophan synthase alpha chain-like isoform X1 [KO:K01695] [EC:4.2.1.20]
114396570  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
114423384  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
114375099  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
114382530  uncharacterized protein LOC114382530 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
gsj00010  Glycolysis / Gluconeogenesis
gsj00020  Citrate cycle (TCA cycle)
gsj00230  Purine metabolism
gsj00250  Alanine, aspartate and glutamate metabolism
gsj00270  Cysteine and methionine metabolism
gsj00290  Valine, leucine and isoleucine biosynthesis
gsj00300  Lysine biosynthesis
gsj00330  Arginine and proline metabolism
gsj00460  Cyanoamino acid metabolism
gsj00470  D-Amino acid metabolism
gsj00564  Glycerophospholipid metabolism
gsj00600  Sphingolipid metabolism
gsj00620  Pyruvate metabolism
gsj00630  Glyoxylate and dicarboxylate metabolism
gsj00640  Propanoate metabolism
gsj00860  Porphyrin metabolism
gsj00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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