Entry
Name
Asthma - Hipposideros armiger (great roundleaf bat)
Description
Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into TH2 cells. Activated TH2 stimulate the formation of IgE by B cells. IgE molecules bind to IgE receptors located on mast cells. The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Mast cells also release chemotactic factors that contribute to the recruitment of inflammatory cells, particularly eosinophils, whose proliferation and differentiation from bone marrow progenitors is promoted by IL-5. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation.
Class
Human Diseases; Immune disease
BRITE hierarchy
Pathway map
Ortholog table
Organism
Hipposideros armiger (great roundleaf bat) [GN:
hai ]
Gene
109373047 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
109392411 HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752 ]
109392415 HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752 ]
109378577 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
109373106 H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752 ]
109373108 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
109373109 HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752 ]
109377860 HLA class II histocompatibility antigen, DQ beta 2 chain-like isoform X1 [KO:K06752 ]
109377861 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
109377862 H-2 class II histocompatibility antigen, A-F alpha chain-like [KO:K06752 ]
109377863 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
109376897 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
109376898 HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752 ]
109378434 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
109378436 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
109376891 SLA class II histocompatibility antigen, DQ haplotype C beta chain-like isoform X1 [KO:K06752 ]
109376893 rano class II histocompatibility antigen, A beta chain-like isoform X1 [KO:K06752 ]
109377864 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
109378145 HLA class II histocompatibility antigen, DO beta chain-like isoform X1 [KO:K06752 ]
109379888 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
109377563 FCER1A; high affinity immunoglobulin epsilon receptor subunit alpha [KO:K08089 ]
109390007 MS4A2; high affinity immunoglobulin epsilon receptor subunit beta [KO:K08090 ]
109376936 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
Compound
C04598 2-Acetyl-1-alkyl-sn-glycero-3-phosphocholine
Reference
Authors
Busse WW, Lemanske RF Jr.
Title
Asthma.
Journal
Reference
Authors
Renauld JC.
Title
New insights into the role of cytokines in asthma.
Journal
Reference
Authors
Romagnani S.
Title
The role of lymphocytes in allergic disease.
Journal
Reference
Authors
Averbeck M, Gebhardt C, Emmrich F, Treudler R, Simon JC.
Title
Immunologic principles of allergic disease.
Journal
Reference
Authors
Conroy DM, Williams TJ.
Title
Eotaxin and the attraction of eosinophils to the asthmatic lung.
Journal
Reference
Authors
Effros RM, Nagaraj H.
Title
Asthma: new developments concerning immune mechanisms, diagnosis and treatment.
Journal
Reference
Authors
Barnes PJ.
Title
Immunology of asthma and chronic obstructive pulmonary disease.
Journal
Reference
Authors
Holgate ST, Polosa R.
Title
Treatment strategies for allergy and asthma.
Journal
Reference
Authors
Valenta R.
Title
The future of antigen-specific immunotherapy of allergy.
Journal
Reference
Authors
Trivedi SG, Lloyd CM.
Title
Eosinophils in the pathogenesis of allergic airways disease.
Journal
Reference
Authors
Heinecke JW.
Title
Eosinophil-dependent bromination in the pathogenesis of asthma.
Journal
Related pathway
hai04060 Cytokine-cytokine receptor interaction
hai04612 Antigen processing and presentation
hai04660 T cell receptor signaling pathway
hai04662 B cell receptor signaling pathway
hai04664 Fc epsilon RI signaling pathway
KO pathway
LinkDB
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