KEGG   ORTHOLOGY: K03160
Entry
K03160                      KO                                     

Symbol
TNFRSF5, CD40
Name
tumor necrosis factor receptor superfamily member 5
Pathway
map04060  Cytokine-cytokine receptor interaction
map04064  NF-kappa B signaling pathway
map04514  Cell adhesion molecules
map04620  Toll-like receptor signaling pathway
map04672  Intestinal immune network for IgA production
map05144  Malaria
map05145  Toxoplasmosis
map05166  Human T-cell leukemia virus 1 infection
map05169  Epstein-Barr virus infection
map05202  Transcriptional misregulation in cancer
map05310  Asthma
map05320  Autoimmune thyroid disease
map05322  Systemic lupus erythematosus
map05330  Allograft rejection
map05340  Primary immunodeficiency
map05416  Viral myocarditis
map05417  Lipid and atherosclerosis
Disease
H00086  Hyper IgM syndromes, autosomal recessive type
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   04514 Cell adhesion molecules
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   04672 Intestinal immune network for IgA production
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05169 Epstein-Barr virus infection
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09174 Infectious disease: parasitic
   05144 Malaria
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05145 Toxoplasmosis
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09163 Immune disease
   05310 Asthma
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05322 Systemic lupus erythematosus
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05320 Autoimmune thyroid disease
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05330 Allograft rejection
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05340 Primary immunodeficiency
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05416 Viral myocarditis
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   04090 CD molecules
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
Cytokine receptors [BR:ko04050]
 Tumor necrosis factor receptors
  TNF receptor superfamily
   K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
CD molecules [BR:ko04090]
 Proteins
  K03160  CD40; tumor necrosis factor receptor superfamily, member 5
Other DBs
GO: 0005031
Genes
HSA: 958(CD40)
PTR: 100615583(CD40)
PPS: 100974274(CD40)
GGO: 101126651(CD40)
PON: 100460237(CD40)
NLE: 100598599(CD40)
MCC: 707749(CD40)
MCF: 102118696(CD40)
CSAB: 103245053(CD40)
CATY: 105588507(CD40)
PANU: 101002143(CD40)
RRO: 104678812(CD40)
RBB: 108533323(CD40)
TFN: 117068863(CD40)
PTEH: 111530033(CD40)
CJC: 100385800(CD40)
SBQ: 101037196(CD40)
MMUR: 105859308(CD40)
MMU: 21939(Cd40)
MCAL: 110289392(Cd40)
MPAH: 110318846(Cd40)
RNO: 171369(Cd40)
MCOC: 116091386(Cd40)
MUN: 110549441(Cd40)
CGE: 100770242(Cd40)
PLEU: 114692638(Cd40)
NGI: 103751235(Cd40)
HGL: 101715501(Cd40)
CPOC: 100728791(Cd40)
CCAN: 109689299(Cd40)
OCU: 100349106(CD40)
OPI: 101522956(CD40)
TUP: 102489413(CD40)
CFA: 403469(CD40)
VVP: 112931927(CD40)
VLG: 121478148(CD40)
AML: 100476345(CD40)
UMR: 103669702(CD40)
UAH: 113258674(CD40)
ORO: 101381578(CD40)
ELK: 111141553
MPUF: 101674384(CD40)
EJU: 114223210(CD40)
MLX: 118011553(CD40)
FCA: 101085363(CD40)
PYU: 121012094(CD40)
PBG: 122467321(CD40)
PTG: 102972342(CD40)
PPAD: 109272341(CD40)
AJU: 106968979(CD40)
HHV: 120243315(CD40)
BTA: 286849(CD40)
BOM: 102274192(CD40)
BIU: 109567510(CD40)
BBUB: 102395805(CD40)
CHX: 102183249(CD40)
OAS: 443232(CD40)
ODA: 120869122(CD40)
CCAD: 122448626(CD40)
SSC: 397395(CD40)
CFR: 102510463(CD40)
CBAI: 105071882(CD40)
CDK: 105087849(CD40)
BACU: 103015045(CD40)
LVE: 103071515(CD40)
OOR: 101278975(CD40)
DLE: 111170146(CD40)
PCAD: 102979165(CD40)
PSIU: 116740845(CD40)
ECB: 100034049(CD40)
EPZ: 103551918(CD40)
EAI: 106843047(CD40)
MYB: 102261551(CD40)
MYD: 102764122(CD40)
MMYO: 118663560(CD40)
MLF: 102439545(CD40)
MNA: 107530873(CD40)
PKL: 118707886(CD40)
HAI: 109379888(CD40)
DRO: 112304112(CD40)
SHON: 118985558(CD40)
AJM: 119063314(CD40)
PDIC: 114506775(CD40)
MMF: 118618725(CD40)
RFQ: 117015694(CD40)
PALE: 102890443(CD40)
PGIG: 120603392(CD40)
RAY: 107514532(CD40)
MJV: 108392900(CD40)
TOD: 119236102(CD40)
LAV: 100666178(CD40)
TMU: 101345594
MDO: 100022240(CD40)
GAS: 123233644(CD40)
SHR: 100935349(CD40)
PCW: 110193707(CD40)
OAA: 114806068(CD40)
GGA: 395385(CD40)
PCOC: 116225542(CD40)
MGP: 104914080(CD40)
CJO: 107323159(CD40)
NMEL: 110408082(CD40)
APLA: 101793419(CD40)
ACYG: 106047117(CD40)
TGU: 100220945(CD40)
LSR: 110476148(CD40)
SCAN: 103818815(CD40)
PMOA: 120497839(CD40)
OTC: 121343747(CD40)
PRUF: 121359605(CD40)
GFR: 102042563(CD40)
FAB: 101814566(CD40)
PHI: 102112115(CD40)
PMAJ: 107213230(CD40)
CCAE: 111945133
CCW: 104687864(CD40)
ETL: 114063004(CD40)
FPG: 101913161(CD40)
FCH: 102059987(CD40)
CLV: 102087204(CD40)
EGZ: 104127954(CD40)
NNI: 104018331(CD40)
PADL: 103921878(CD40)
AAM: 106497584(CD40)
AROW: 112976008(CD40)
NPD: 112949722(CD40)
DNE: 112992151(CD40)
ASN: 102368316(CD40)
AMJ: 102563086(CD40)
CPOO: 109313126(CD40)
GGN: 109292469(CD40)
CMY: 102941434(CD40)
CPIC: 101933419 101935395(CD40)
TST: 117886242(CD40)
CABI: 116833810(CD40)
MRV: 120379730(CD40)
ACS: 103281538
PVT: 110086225(CD40)
SUND: 121929790(CD40)
PBI: 103064466
PMUR: 107299409
TSR: 106552116 106555533(CD40)
PGUT: 117669598(CD40)
PMUA: 114599900(CD40)
ZVI: 118089489(CD40)
GJA: 107108043(CD40)
XLA: 108701036(cd40.L) 108702730(cd40.S)
XTR: 100270675(cd40)
NPR: 108789107(CD40)
DRE: 100270764(cd40)
IPU: 108276426
PHYP: 113530253
AMEX: 111194086
EEE: 113576322
TRU: 100271746(cd40)
ELY: 117258592(cd40) 117265765
SLUC: 116043738(cd40) 116049710
ECRA: 117946268 117947924(cd40)
PPUG: 119197259 119222778(cd40)
MSAM: 119886450(tnfrsf18) 119897434 119905141(cd40)
CUD: 121513648 121518212(cd40)
OAU: 116321990(cd40) 116323797
OML: 112143700 112159499(cd40)
XMA: 102228192
XCO: 114140764
XHE: 116717234 116717759(ltbr)
PRET: 103467842(tnfrsf18)
GAF: 122831005 122833124(cd40)
CTUL: 119783090 119799365(cd40)
KMR: 108231249 108237606(cd40)
ALIM: 106531985
CSEM: 103385708(tnfrsf9)
SSEN: 122774114 122776967(cd40)
HHIP: 117764844(cd40) 117776820
SDU: 111234934
SLAL: 111644164
XGL: 120784114 120804440(cd40)
OTW: 112216294 112221793(cd40)
ELS: 105013652
AANG: 118208336(cd40)
ARUT: 117428173
LCM: 102356863(CD40) 106705104
BFO: 118407166
BBEL: 109487495
CRG: 105348770
 » show all
Reference
PMID:2475341
  Authors
Stamenkovic I, Clark EA, Seed B
  Title
A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.
  Journal
EMBO J 8:1403-10 (1989)
DOI:10.1002/j.1460-2075.1989.tb03521.x
  Sequence
[hsa:958]
Reference
  Authors
Elgueta R, Benson MJ, de Vries VC, Wasiuk A, Guo Y, Noelle RJ
  Title
Molecular mechanism and function of CD40/CD40L engagement in the immune system.
  Journal
Immunol Rev 229:152-72 (2009)
DOI:10.1111/j.1600-065X.2009.00782.x
Reference
  Authors
Eliopoulos AG, Wang CC, Dumitru CD, Tsichlis PN
  Title
Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.
  Journal
EMBO J 22:3855-64 (2003)
DOI:10.1093/emboj/cdg386
  Sequence
[mmu:21939]
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