KEGG ORTHOLOGY: K03160

ORTHOLOGY: K03160

Entry

K03160                      KO

Symbol

TNFRSF5, CD40

Name

tumor necrosis factor receptor superfamily member 5

Pathway

map04060

Cytokine-cytokine receptor interaction

map04064

NF-kappa B signaling pathway

map04514

Cell adhesion molecules

map04620

Toll-like receptor signaling pathway

map04672

Intestinal immune network for IgA production

map05144

Malaria

map05145

Toxoplasmosis

map05166

Human T-cell leukemia virus 1 infection

map05169

Epstein-Barr virus infection

map05202

Transcriptional misregulation in cancer

map05310

Asthma

map05320

Autoimmune thyroid disease

map05322

Systemic lupus erythematosus

map05330

Allograft rejection

map05340

Primary immunodeficiency

map05416

Viral myocarditis

map05417

Lipid and atherosclerosis

Disease

H00086

Immunodeficiency with hyper-IgM

H00093

Combined immunodeficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   04514 Cell adhesion molecules
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   04672 Intestinal immune network for IgA production
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05169 Epstein-Barr virus infection
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09174 Infectious disease: parasitic
   05144 Malaria
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05145 Toxoplasmosis
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09163 Immune disease
   05310 Asthma
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05322 Systemic lupus erythematosus
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05320 Autoimmune thyroid disease
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05330 Allograft rejection
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05340 Primary immunodeficiency
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   05416 Viral myocarditis
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
   04090 CD molecules
    K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
Cytokine receptors [BR:ko04050]
Tumor necrosis factor receptors
  TNF receptor superfamily
   K03160  TNFRSF5, CD40; tumor necrosis factor receptor superfamily member 5
CD molecules [BR:ko04090]
Proteins
  K03160  CD40; tumor necrosis factor receptor superfamily, member 5

Other DBs

GO:

0005031

Genes

HSA:

958(CD40)

PTR:	100615583(CD40)

PPS:	100974274(CD40)

GGO:	101126651(CD40)

PON:	100460237(CD40)

PPYG:

129021946(CD40)

NLE:	100598599(CD40)

HMH:	116461078(CD40)

SSYN:

129474730(CD40)

MCC:	707749(CD40)

MCF:	102118696(CD40)

MTHB:

126963852

MNI:	105496469(CD40)

CSAB:

103245053(CD40)

CATY:

105588507(CD40)

PANU:

101002143(CD40)

TGE:	112633025(CD40)

MLEU:

105542289(CD40)

RRO:	104678812(CD40)

RBB:	108533323(CD40)

TFN:	117068863(CD40)

PTEH:

111530033(CD40)

CANG:

105502405(CD40)

CJC:	100385800(CD40)

SBQ:	101037196(CD40)

CIMI:

108313050(CD40)

ANAN:

105727477(CD40)

CSYR:

103260263(CD40)

MMUR:

105859308(CD40)

LCAT:

123622328(CD40)

PCOQ:

105807125(CD40)

OGA:	100943964(CD40)

MMU:	21939(Cd40)

MCAL:

110289392(Cd40)

MPAH:

110318846(Cd40)

RNO:	171369(Cd40)

MCOC:

116091386(Cd40)

ANU:	117703570(Cd40)

MUN:	110549441(Cd40)

CGE:	100770242(Cd40)

MAUA:

101822705(Cd40)

PROB:

127223637(Cd40)

PLEU:

114692638(Cd40)

MORG:

121460322(Cd40)

MFOT:

126507111

AAMP:

119814659(Cd40)

NGI:	103751235(Cd40)

HGL:	101715501(Cd40)

CPOC:

100728791(Cd40)

CCAN:

109689299(Cd40)

DORD:

105981696(Cd40)

DSP:	122120440(Cd40)

PLOP:

125353853(Cd40)

NCAR:

124978300

MMMA:

107136751(Cd40)

OCU:

100349106

OPI:	101522956(CD40)

TUP:	102489413(CD40)

GVR:	103589570(CD40)

CFA:	403469(CD40)

CLUD:

112674058(CD40)

VVP:	112931927(CD40)

VLG:	121478148(CD40)

NPO:	129521609(CD40)

AML:	100476345(CD40)

UMR:	103669702(CD40)

UAH:	113258674(CD40)

UAR:	123797062(CD40)

ELK:

111141553

LLV:

125109530

MPUF:

101674384(CD40)

MNP:	132021990(CD40)

MLK:	131807685(CD40)

NVS:	122915550(CD40)

ORO:	101381578(CD40)

EJU:	114223210(CD40)

ZCA:	113938082(CD40)

MLX:	118011553(CD40)

NSU:	110579528(CD40)

LWW:	102732296(CD40)

FCA:	101085363(CD40)

PYU:	121012094(CD40)

PCOO:

112869205(CD40)

PBG:	122467321(CD40)

PVIV:

125161911(CD40)

LRUF:

124504027

PTG:	102972342(CD40)

PPAD:

109272341(CD40)

PUC:

125936517

AJU:

106968979

HHV:	120243315(CD40)

BTA:	286849(CD40)

BOM:	102274192(CD40)

BIU:	109567510(CD40)

BBUB:

102395805(CD40)

BBIS:

104985052(CD40)

CHX:	102183249(CD40)

OAS:	443232(CD40)

BTAX:

128058688(CD40)

ODA:	120869122(CD40)

CCAD:

122448626(CD40)

MBEZ:

129564291(CD40)

SSC:	397395(CD40)

CFR:	102510463(CD40)

CBAI:

105071882(CD40)

CDK:	105087849(CD40)

VPC:	102527375(CD40)

BACU:

103015045(CD40)

BMUS:

118880531(CD40)

LVE:	103071515(CD40)

OOR:	101278975(CD40)

DLE:	111170146(CD40)

PCAD:

102979165(CD40)

PSIU:

116740845(CD40)

NASI:

112400901(CD40)

ECB:	100034049(CD40)

EPZ:	103551918(CD40)

EAI:	106843047(CD40)

MYB:	102261551(CD40)

MYD:	102764122(CD40)

MMYO:

118663560(CD40)

MLF:	102439545(CD40)

MDT:	132239872(CD40)

PKL:	118707886(CD40)

EFUS:

103301981(CD40)

MNA:	107530873(CD40)

DRO:	112304112(CD40)

SHON:

118985558(CD40)

AJM:	119063314(CD40)

PDIC:

114506775(CD40)

PHAS:

123814884(CD40)

MMF:	118618725(CD40)

PPAM:

129070434(CD40)

HAI:	109379888(CD40)

RFQ:	117015694(CD40)

PALE:

102890443(CD40)

PGIG:

120603392(CD40)

PVP:	105298191(CD40)

RAY:	107514532(CD40)

MJV:	108392900(CD40)

TOD:	119236102(CD40)

SARA:

101546061(CD40)

SETR:

126018394(CD40)

LAV:	100666178(CD40)

TMU:

101345594

ETF:	123522305(CD40)

DNM:	101440382(CD40)

MDO:	100022240(CD40)

GAS:	123233644(CD40)

SHR:	100935349(CD40)

AFZ:

127550777

PCW:	110193707(CD40)

TVP:	118840774(CD40)

OAA:	114806068(CD40)

GGA:	395385(CD40)

PCOC:

116225542(CD40)

MGP:	104914080(CD40)

CJO:	107323159(CD40)

TPAI:

128080831(CD40)

LMUT:

125701060(CD40)

NMEL:

110408082(CD40)

APLA:

101793419(CD40)

ACYG:

106047117(CD40)

CATA:

118258403(CD40)

AFUL:

116495714(CD40)

TGU:	100220945(CD40)

LSR:	110476148(CD40)

SCAN:

103818815(CD40)

PMOA:

120497839(CD40)

OTC:	121343747(CD40)

PRUF:

121359605(CD40)

GFR:	102042563(CD40)

FAB:	101814566(CD40)

OMA:	130261374(CD40)

PHI:	102112115(CD40)

PMAJ:

107213230(CD40)

CCAE:

111945133

CCW:	104687864(CD40)

CBRC:

103617287(CD40)

ETL:	114063004(CD40)

ZAB:	102069643(CD40)

ZLE:	135456430(CD40)

ACHL:

103808426(CD40)

SVG:	106860881(CD40)

MMEA:

130573507(CD40)

HRT:	120759965(CD40)

SATI:

136368454(CD40)

FPG:	101913161(CD40)

FCH:	102059987(CD40)

CCRI:

104157779

NNT:	104411857(CD40)

SHAB:

115615020(CD40)

TALA:

104366601(CD40)

ACHC:

115338768(CD40)

HALD:

104313377

HLE:	104833147(CD40)

AGEN:

GCL:

CSTI:

LDI:

MNB:	103775339(CD40)

DPUB:

104301482(CD40)

AVIT:

104268563

BRHI:

104501352(CD40)

EGZ:	104127954(CD40)

NNI:	104018331(CD40)

PCRI:

104030185

PCAO:

104047557

PADL:

103921878(CD40)

AFOR:

103899127(CD40)

FGA:

104084243

GSTE:

104264236(CD40)

CLV:	102087204(CD40)

PLET:

104619590(CD40)

CMAC:

104485413

TEO:	104377261(CD40)

BREG:

104630431(CD40)

OHA:	104333287(CD40)

ACAR:

104518897(CD40)

CPEA:

104385566(CD40)

CVF:	104293957(CD40)

RTD:	128916816(CD40)

AAM:	106497584(CD40)

AROW:

112976008(CD40)

NPD:	112949722(CD40)

TGT:

104575468

DNE:	112992151(CD40)

ASN:	102368316(CD40)

AMJ:	102563086(CD40)

CPOO:

109313126(CD40)

GGN:	109292469(CD40)

CMY:	102941434(CD40)

CCAY:

125622305(CD40)

DCC:	119841917(CD40)

CPIC:

101933419 101935395(CD40)

TST:	117886242(CD40)

CABI:

116833810(CD40)

MRV:	120379730(CD40)

ACS:

103281538

ASAO:

132772713(CD40)

PVT:	110086225(CD40)

SUND:

121929790(CD40)

PBI:

103064466

PMUR:

107299409

TSR:	106552116 106555533(CD40)

PGUT:

117669598(CD40)

APRI:

131194702(CD40)

PTEX:

113450541(CD40)

NSS:	113425357(CD40)

PMUA:

114599900(CD40)

PRAF:

128415498(CD40)

ZVI:	118089489(CD40)

HCG:	128322156(CD40)

GJA:	107108043(CD40)

STOW:

125432401(CD40)

EMC:	129329679(CD40)

XLA:	108701036(cd40.L) 108702730(cd40.S)

XTR:	100270675(cd40)

NPR:	108789107(CD40)

RTEM:

120918549(CD40)

BBUF:

121004804(CD40)

BGAR:

122940933(CD40)

MUO:	115457795 115476657(CD40)

GSH:	117345522(CD40) 117350687

DRE:	100270764(cd40)

SRX:	107714941 107751858

SANH:

107664245 107697852

SGH:	107565882 107577234 107599738

CCAR:

109051919 109101015

CAUA:

113041201 113065701 113081470

CGIB:

127944779 128012032

PTET:

122332875(cd40)

LROH:

127154721(cd40)

OMC:	131532705(cd40)

PPRM:

120463640(cd40)

RKG:	130090607(cd40)

MAMB:

125260055(cd40)

CIDE:

127505048

CERY:

137009461(cd40)

MASI:

127418819 127420002

TROS:

130545019(cd40)

TDW:	130409318(cd40)

MANU:

129431220(cd40)

IPU:	108276426(cd40)

IFU:	128619670(cd40)

PHYP:

113530253

SMEO:

124385268 124398630(cd40)

TFD:	113641992(cd40)

TVC:	132861858(cd40)

TRN:	134333506(cd40)

AMEX:

111194086(cd40)

CMAO:

118822628(cd40)

EEE:

113576322

CHAR:

105901608 105906406(cd40)

TRU:	100271746(cd40) 101073138

TFS:	130530672(cd40) 130533012

TNG:	GSTEN00015324G001 GSTEN00023414G001

LCO:	104932110 104932548

NCC:	104947926 104958049

TBEN:

117483402(cd40) 117494728

CGOB:

115011458 115021686

PGEO:

117449231(cd40) 117460708

GACU:

117547448(cd40) 117556350

EMAC:

134861285 134862828(cd40)

ELY:	117258592(cd40) 117265765

EFO:	125891870(cd40) 125893151

PLEP:

121945282 121947530(cd40) 121964685

SLUC:

116043738(cd40) 116049710

ECRA:

117946268 117947924(cd40)

ESP:	116691279 116692942

PFLV:

114557511 114558705

GAT:	100462700 120810413

PPUG:

119197259 119222778(cd40)

AFB:	129099789(cd40) 129109556

CLUM:

117733136(cd40) 117745476

PSWI:

130199653(cd40) 130213471

MSAM:

119897434 119905141(cd40)

SCHU:

122882071 122883288(cd40)

CUD:	121513648 121518212(cd40)

ALAT:

119006366 119023509(cd40)

MZE:	101478307 101487191

ONL:	100703947 102079592 102082497

OAU:	116321990(cd40) 116323797

OLA:	100301586 105355953

OML:	112143700 112159499(cd40)

CSAI:

133434902 133456783(cd40)

XMA:	102228192 111608091(ltbr)

XCO:	114140764 114142164(ltbr)

XHE:	116717234 116717759(ltbr)

PRET:

103467842(tnfrsf18)

PFOR:

103136747(ltbr) 103150965

PLAI:

106955770 106962807

PMEI:

106913056 106921382(ltbr)

GAF:	122831005 122833124(cd40)

PPRL:

129371500 129377124(cd40)

CVG:	107082174(ltbr) 107083714

CTUL:

119783090 119799365(cd40)

GMU:	124863216 124871462(cd40)

NFU:	107379457(ltbr) 107385208 107390437

KMR:	108231249 108237606(cd40)

ALIM:

106531985

NWH:	119409703 119416602(cd40)

AOCE:

111566221 111584762

MCEP:

125016114

POV:	109633310 109640984

SSEN:

122774114 122776967(cd40)

HHIP:

117764844(cd40) 117776820

HSP:	118110871(cd40) 118113227

PPLT:

128442498(cd40) 128448994

SMAU:

118315341 118316527(cd40)

LCF:	108892295(cd40)

SDU:

111234934

SLAL:

111644164

XGL:	120784114 120804440(cd40)

HCQ:	109513557 109515324

SSCV:

125975775

SBIA:

133500730 133510667(cd40)

PEE:	133401424 133413464(cd40)

PTAO:

133479926 133486086(cd40)

BPEC:

110154612 110163026 110168662

MALB:

109966220 109971027

BSPL:

114842952 114858865(cd40)

SJO:	128358014(cd40) 128366271

SASA:

100196207(tnr5) 106567123 106575707 106576603

STRU:

115165602 115167949

OTW:	112216294 112221793(cd40)

OMY:	100136071(tnfr) 101268950(cd40) 101268951 110509563

OGO:	124032198 124046015(cd40)

ONE:	115102483 115132442

OKI:	109869348 109908247

OKE:	118360014 118360743

SALP:

111966743 111977095 112074550

SNH:	120040917 120042254 120059160 120061082(cd40)

ELS:

105013652

SFM:	108922332 108939243

PKI:	111833952 111855639

AANG:

118208336(cd40)

LOC:	102697660 107076369

PSPA:

121297916 121319187

ARUT:

117428173

LCM:	102356863(CD40) 106705104

CMK:	103191363 103191371 103191377

RTP:	109913577 109913578

CPLA:

122560003 122560004 122560005

HOC:	132822702 132822889 132822890

LERI:

129707180 129707181 129711682 129711749

PMRN:

LRJ:

BFO:

BBEL:

HRF:	124112710 124127082

HRJ:

124260804

PMAX:

117337746 117344554 117344631

MAEA:

128231894

TBG:	TbgDal_X13670

» show all

Reference

PMID:2475341

Authors

Stamenkovic I, Clark EA, Seed B

Title

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

Journal

EMBO J 8:1403-10 (1989)
DOI:10.1002/j.1460-2075.1989.tb03521.x

Sequence

[hsa:958]

Reference

PMID:19426221

Authors

Elgueta R, Benson MJ, de Vries VC, Wasiuk A, Guo Y, Noelle RJ

Title

Molecular mechanism and function of CD40/CD40L engagement in the immune system.

Journal

Immunol Rev 229:152-72 (2009)
DOI:10.1111/j.1600-065X.2009.00782.x

Reference

PMID:12881420

Authors

Eliopoulos AG, Wang CC, Dumitru CD, Tsichlis PN

Title

Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

Journal

EMBO J 22:3855-64 (2003)
DOI:10.1093/emboj/cdg386

Sequence

[mmu:21939]

LinkDB

DBGET integrated database retrieval system