KEGG   PATHWAY: halu00630
Entry
halu00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Halorarum salinum
Class
Metabolism; Carbohydrate metabolism
Pathway map
halu00630  Glyoxylate and dicarboxylate metabolism
halu00630

Module
halu_M00621  Glycine cleavage system [PATH:halu00630]
halu_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:halu00630]
halu_M00968  Pentose bisphosphate pathway (nucleoside degradation), archaea, nucleoside/NMP => 3-PGA/glycerone phosphate [PATH:halu00630]
Other DBs
GO: 0046487 0043648
Organism
Halorarum salinum [GN:halu]
Gene
HUG12_18585  isocitrate lyase/PEP mutase family protein [KO:K01637] [EC:4.1.3.1 4.1.3.30]
HUG12_07760  AMP-binding protein [KO:K01895] [EC:6.2.1.1]
HUG12_11680  AMP-binding protein [KO:K01895] [EC:6.2.1.1]
HUG12_01845  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
HUG12_08240  lactate dehydrogenase [KO:K00024] [EC:1.1.1.37]
HUG12_03180  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
HUG12_12855  citrate synthase/methylcitrate synthase [KO:K01647] [EC:2.3.3.1]
HUG12_19340  citrate synthase [KO:K01659] [EC:2.3.3.5]
HUG12_00265  citrate synthase [KO:K01659] [EC:2.3.3.5]
HUG12_13440  thiolase family protein [KO:K00626] [EC:2.3.1.9]
HUG12_17630  thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]
HUG12_19855  thiolase family protein [KO:K00626] [EC:2.3.1.9]
HUG12_20205  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
HUG12_21050  MaoC family dehydratase [KO:K17865] [EC:4.2.1.55]
HUG12_10265  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
HUG12_13740  acetyl-CoA carboxylase biotin carboxylase subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
HUG12_13760  acyl-CoA carboxylase subunit beta [KO:K19312] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
HUG12_13755  acc operon protein [KO:K22568] [EC:6.4.1.2 6.4.1.3]
HUG12_17610  cobalamin B12-binding domain-containing protein [KO:K01849] [EC:5.4.99.2]
HUG12_10260  methylmalonyl-CoA mutase family protein [KO:K01848] [EC:5.4.99.2]
HUG12_01850  methylmalonyl-CoA mutase family protein [KO:K01848] [EC:5.4.99.2]
HUG12_13540  malate synthase [KO:K19282] [EC:4.1.3.24 3.1.2.30]
HUG12_04620  D-glycerate dehydrogenase [KO:K00015] [EC:1.1.1.26]
HUG12_06295  HAD family hydrolase [KO:K01091] [EC:3.1.3.18]
HUG12_13585  HAD family hydrolase [KO:K01091] [EC:3.1.3.18]
HUG12_08785  HAD-IIB family hydrolase [KO:K22223] [EC:3.1.3.18]
HUG12_12340  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
HUG12_17205  gltB; glutamate synthase large subunit [KO:K00284] [EC:1.4.7.1]
HUG12_02400  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
HUG12_13355  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HUG12_18605  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
HUG12_18600  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
HUG12_18645  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HUG12_19590  aminomethyl transferase family protein [KO:K00605] [EC:2.1.2.10]
HUG12_03415  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HUG12_18635  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HUG12_08750  NAD(P)-dependent oxidoreductase [KO:K00042] [EC:1.1.1.60]
HUG12_08255  DUF4147 domain-containing protein [KO:K11529] [EC:2.7.1.165]
HUG12_11475  DUF4147 domain-containing protein [KO:K11529] [EC:2.7.1.165]
HUG12_04655  DUF4147 domain-containing protein [KO:K11529] [EC:2.7.1.165]
HUG12_19110  HAD family hydrolase [KO:K26210] [EC:3.1.3.109]
HUG12_19105  class II aldolase/adducin family protein [KO:K01636] [EC:4.1.2.-]
HUG12_19820  tartrate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
HUG12_07600  bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
HUG12_06460  formate dehydrogenase subunit alpha [KO:K00123] [EC:1.17.1.9]
HUG12_17820  molybdopterin-dependent oxidoreductase [KO:K00123] [EC:1.17.1.9]
HUG12_06455  4Fe-4S dicluster domain-containing protein [KO:K00124]
HUG12_06390  formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
HUG12_18815  acetamidase/formamidase family protein [KO:K01455] [EC:3.5.1.49]
HUG12_20620  acetamidase/formamidase family protein [KO:K01455] [EC:3.5.1.49]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
halu00010  Glycolysis / Gluconeogenesis
halu00020  Citrate cycle (TCA cycle)
halu00030  Pentose phosphate pathway
halu00053  Ascorbate and aldarate metabolism
halu00071  Fatty acid degradation
halu00230  Purine metabolism
halu00250  Alanine, aspartate and glutamate metabolism
halu00260  Glycine, serine and threonine metabolism
halu00620  Pyruvate metabolism
halu00710  Carbon fixation by Calvin cycle
halu00750  Vitamin B6 metabolism
halu00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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