KEGG PATHWAY: hie00260

PATHWAY: hie00260

Entry

hie00260                    Pathway

Name

Glycine, serine and threonine metabolism - Haemophilus influenzae R2846 (nontypeable)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

hie00260

Glycine, serine and threonine metabolism

Module

hie_M00018

Threonine biosynthesis, aspartate => homoserine => threonine [PATH:hie00260]

hie_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:hie00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Haemophilus influenzae R2846 (nontypeable) [GN:hie]

Gene

R2846_0554

thrA; Aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]

R2846_1690

asd; Ribosomal protein S12 methylthiotransferase [KO:K00133] [EC:1.2.1.11]

R2846_0555

thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]

R2846_0556

thrC; Threonine synthase [KO:K01733] [EC:4.2.3.1]

R2846_1427

glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]

R2846_1031

hprA; Glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]

R2846_0552

garK; Glycerate kinase [KO:K00865] [EC:2.7.1.165]

R2846_1568

gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]

R2846_0114

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

R2846_1175

serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

R2846_1299

serB; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

R2846_0907

ydfG; NADP-dependent L-serine/L-allo-threonine dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]

R2846_0758

lpdA; Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]

R2846_0155

pssA; Phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]

R2846_0293

sdaA; L-serine deaminase [KO:K01752] [EC:4.3.1.17]

R2846_1587

ilvA; Threonine deaminase [KO:K01754] [EC:4.3.1.19]

R2846_0909

trpA; Tryptophan synthase, alpha subunit [KO:K01695] [EC:4.2.1.20]

R2846_0908

trpB; Tryptophan synthase, beta subunit [KO:K01696] [EC:4.2.1.20]

R2846_1360

dat; L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase aminotransferase [KO:K00836] [EC:2.6.1.76]

R2846_1363

ddc; L-2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721