KEGG   PATHWAY: kco00260
Entry
kco00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Kosakonia cowanii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kco00260  Glycine, serine and threonine metabolism
kco00260

Module
kco_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kco00260]
kco_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kco00260]
kco_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kco00260]
kco_M00555  Betaine biosynthesis, choline => betaine [PATH:kco00260]
kco_M00621  Glycine cleavage system [PATH:kco00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Kosakonia cowanii [GN:kco]
Gene
BWI95_04145  lysine-sensitive aspartokinase 3 [KO:K00928] [EC:2.7.2.4]
BWI95_02200  bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
BWI95_00945  metL; bifunctional aspartokinase II/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]
BWI95_03790  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
BWI95_02195  homoserine kinase [KO:K00872] [EC:2.7.1.39]
BWI95_02190  threonine synthase [KO:K01733] [EC:4.2.3.1]
BWI95_13255  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
BWI95_00435  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BWI95_10645  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
BWI95_13970  bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
BWI95_08715  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
BWI95_10175  glycerate kinase [KO:K00865] [EC:2.7.1.165]
BWI95_07070  glycerate 2-kinase [KO:K00865] [EC:2.7.1.165]
BWI95_12530  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
BWI95_02245  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
BWI95_08505  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BWI95_06180  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
BWI95_13410  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
BWI95_02285  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
BWI95_15850  NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
BWI95_08480  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
BWI95_08485  L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
BWI95_06130  glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
BWI95_06140  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
BWI95_01720  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BWI95_11225  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
BWI95_06135  glycine cleavage system protein H [KO:K02437]
BWI95_00605  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
BWI95_06490  hypothetical protein [KO:K17103] [EC:2.7.8.8]
BWI95_02770  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
BWI95_02775  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
BWI95_05835  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
BWI95_05840  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
BWI95_10115  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BWI95_18580  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
BWI95_22965  PLP-dependent threonine dehydratase [KO:K01754] [EC:4.3.1.19]
BWI95_21595  serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
BWI95_05760  aspartate/glutamate racemase [KO:K25316] [EC:5.1.1.10]
BWI95_17475  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
BWI95_17470  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kco00010  Glycolysis / Gluconeogenesis
kco00020  Citrate cycle (TCA cycle)
kco00230  Purine metabolism
kco00250  Alanine, aspartate and glutamate metabolism
kco00270  Cysteine and methionine metabolism
kco00290  Valine, leucine and isoleucine biosynthesis
kco00300  Lysine biosynthesis
kco00330  Arginine and proline metabolism
kco00460  Cyanoamino acid metabolism
kco00470  D-Amino acid metabolism
kco00564  Glycerophospholipid metabolism
kco00600  Sphingolipid metabolism
kco00620  Pyruvate metabolism
kco00630  Glyoxylate and dicarboxylate metabolism
kco00640  Propanoate metabolism
kco00680  Methane metabolism
kco00860  Porphyrin metabolism
kco00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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