KEGG   PATHWAY: kla03040
Entry
kla03040                    Pathway                                
Name
Spliceosome - Kluyveromyces lactis
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
kla03040  Spliceosome
kla03040

Other DBs
GO: 0005681
Organism
Kluyveromyces lactis [GN:kla]
Gene
KLLA0_D19455r  SNR19; U1 RNA [KO:K14276]
KLLA0_F10776r  SNR20; U2 RNA [KO:K14277]
KLLA0_D13566r  SNR14; U4 RNA [KO:K14278]
KLLA0_E15929r  SNR7; U5 RNA [KO:K14279]
KLLA0_F19950r  SNR6; U6 RNA [KO:K14280]
KLLA0_F10505g  uncharacterized protein [KO:K12811] [EC:5.6.2.7]
KLLA0_E21935g  uncharacterized protein [KO:K12812] [EC:5.6.2.7]
KLLA0_F06204g  uncharacterized protein [KO:K12814] [EC:5.6.2.6]
KLLA0_A07733g  uncharacterized protein [KO:K12815] [EC:5.6.2.6]
KLLA0_E21187g  uncharacterized protein [KO:K12816]
KLLA0_C18172g  uncharacterized protein [KO:K12817]
KLLA0_B11638g  uncharacterized protein [KO:K12818] [EC:5.6.2.6]
KLLA0_F14531g  uncharacterized protein [KO:K12819]
KLLA0_B00561g  uncharacterized protein [KO:K12820] [EC:5.6.2.6]
KLLA0_B00627g  uncharacterized protein [KO:K11086]
KLLA0_D03773g  uncharacterized protein [KO:K11087]
KLLA0_D09284g  uncharacterized protein [KO:K11096]
KLLA0_D17160g  uncharacterized protein [KO:K11088]
KLLA0_A02299g  uncharacterized protein [KO:K11097]
KLLA0_E04929g  uncharacterized protein [KO:K11098]
KLLA0_D07678g  uncharacterized protein [KO:K11099]
KLLA0_C08019g  uncharacterized protein [KO:K11093]
KLLA0_A04565g  uncharacterized protein [KO:K11095]
KLLA0_C05192g  uncharacterized protein [KO:K11095]
KLLA0_E18239g  uncharacterized protein [KO:K12821]
KLLA0_F23716g  uncharacterized protein [KO:K12823] [EC:5.6.2.7]
KLLA0_B02156g  uncharacterized protein [KO:K11092]
KLLA0_C03322g  uncharacterized protein [KO:K12825]
KLLA0_F22473g  uncharacterized protein [KO:K12826]
KLLA0_F24662g  uncharacterized protein [KO:K12827]
KLLA0_A09537g  uncharacterized protein [KO:K12828]
KLLA0_F08481g  uncharacterized protein [KO:K12829]
KLLA0_A08129g  uncharacterized protein [KO:K12830]
KLLA0_C14388g  uncharacterized protein [KO:K12831]
KLLA0_A11605g  uncharacterized protein [KO:K12832]
KLLA0_C15675g  uncharacterized protein [KO:K12834]
KLLA0_F26433g  uncharacterized protein [KO:K12837]
KLLA0_F09207g  uncharacterized protein [KO:K12621]
KLLA0_B05203g  uncharacterized protein [KO:K12622]
KLLA0_E20813g  uncharacterized protein [KO:K12623]
KLLA0_E10209g  uncharacterized protein [KO:K12624]
KLLA0_E02575g  uncharacterized protein [KO:K12625]
KLLA0_E22881g  uncharacterized protein [KO:K12626]
KLLA0_E16457g  uncharacterized protein [KO:K12627]
KLLA0_E09285g  uncharacterized protein [KO:K12843]
KLLA0_E04819g  uncharacterized protein [KO:K12662]
KLLA0_D14883g  uncharacterized protein [KO:K12844]
KLLA0_E22529g  small nucleolar ribonucleoprotein SNU13 [KO:K12845]
KLLA0_E14125g  uncharacterized protein [KO:K12847]
KLLA0_F08591g  uncharacterized protein [KO:K11984]
KLLA0_E01409g  uncharacterized protein [KO:K12848]
KLLA0_D03795g  uncharacterized protein [KO:K12851]
KLLA0_A06688g  uncharacterized protein [KO:K12853]
KLLA0_C17798g  uncharacterized protein [KO:K12854] [EC:5.6.2.6]
KLLA0_F04191g  uncharacterized protein [KO:K12855]
KLLA0_A05280g  uncharacterized protein [KO:K12856]
KLLA0_C15433g  uncharacterized protein [KO:K12858] [EC:5.6.2.7]
KLLA0_B08910g  uncharacterized protein [KO:K12859]
KLLA0_D03883g  uncharacterized protein [KO:K10599] [EC:2.3.2.27]
KLLA0_C07304g  uncharacterized protein [KO:K12860]
KLLA0_F11231g  uncharacterized protein [KO:K12862]
KLLA0_D16896g  uncharacterized protein [KO:K12863]
KLLA0_E20527g  uncharacterized protein [KO:K03283]
KLLA0_D04224g  uncharacterized protein [KO:K03283]
KLLA0_D19041g  uncharacterized protein [KO:K03283]
KLLA0_F02475g  uncharacterized protein [KO:K06063]
KLLA0_A01969g  uncharacterized protein [KO:K12867]
KLLA0_E04643g  uncharacterized protein [KO:K12868]
KLLA0_F17996g  uncharacterized protein [KO:K12869]
KLLA0_F16841g  uncharacterized protein [KO:K12870]
KLLA0_F18502g  uncharacterized protein [KO:K12872]
KLLA0_C08800g  uncharacterized protein [KO:K12873]
KLLA0_A10659g  uncharacterized protein [KO:K13025] [EC:5.6.2.7]
KLLA0_A11594g  uncharacterized protein [KO:K12879]
KLLA0_C02849g  uncharacterized protein [KO:K12880]
KLLA0_E02751g  uncharacterized protein [KO:K12881]
KLLA0_F17523g  uncharacterized protein [KO:K12882]
KLLA0_B10472g  uncharacterized protein [KO:K12883]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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