KEGG   PATHWAY: kng00260
Entry
kng00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Huiozyma naganishii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kng00260  Glycine, serine and threonine metabolism
kng00260

Module
kng_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kng00260]
kng_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kng00260]
kng_M00621  Glycine cleavage system [PATH:kng00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Huiozyma naganishii [GN:kng]
Gene
KNAG_0L01370  KNAG0L01370; hypothetical protein [KO:K00928] [EC:2.7.2.4]
KNAG_0A05070  KNAG0A05070; hypothetical protein [KO:K00133] [EC:1.2.1.11]
KNAG_0F02700  KNAG0F02700; hypothetical protein [KO:K00872] [EC:2.7.1.39]
KNAG_0I02560  KNAG0I02560; hypothetical protein [KO:K01733] [EC:4.2.3.1]
KNAG_0G00410  KNAG0G00410; hypothetical protein [KO:K01620] [EC:4.1.2.48]
KNAG_0C01850  KNAG0C01850; hypothetical protein [KO:K00600] [EC:2.1.2.1]
KNAG_0E03250  KNAG0E03250; hypothetical protein [KO:K00600] [EC:2.1.2.1]
KNAG_0E03240  KNAG0E03240; hypothetical protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
KNAG_0F02780  KNAG0F02780; hypothetical protein [KO:K01834] [EC:5.4.2.11]
KNAG_0K01200  KNAG0K01200; hypothetical protein [KO:K01834] [EC:5.4.2.11]
KNAG_0G00760  KNAG0G00760; hypothetical protein [KO:K15918] [EC:2.7.1.31]
KNAG_0C04190  KNAG0C04190; hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KNAG_0L01750  KNAG0L01750; hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KNAG_0M00940  KNAG0M00940; hypothetical protein [KO:K00831] [EC:2.6.1.52]
KNAG_0G00730  KNAG0G00730; hypothetical protein [KO:K01079] [EC:3.1.3.3]
KNAG_0J02140  KNAG0J02140; hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KNAG_0A04260  KNAG0A04260; hypothetical protein [KO:K00643] [EC:2.3.1.37]
KNAG_0F01650  KNAG0F01650; hypothetical protein [KO:K00281] [EC:1.4.4.2]
KNAG_0H01390  KNAG0H01390; hypothetical protein [KO:K00605] [EC:2.1.2.10]
KNAG_0L00360  KNAG0L00360; hypothetical protein [KO:K00382] [EC:1.8.1.4]
KNAG_0D05050  KNAG0D05050; hypothetical protein [KO:K02437]
KNAG_0E01580  KNAG0E01580; hypothetical protein [KO:K17103] [EC:2.7.8.8]
KNAG_0B00640  KNAG0B00640; hypothetical protein [KO:K17103] [EC:2.7.8.8]
KNAG_0J02670  KNAG0J02670; hypothetical protein [KO:K01697] [EC:4.2.1.22]
KNAG_0D04740  KNAG0D04740; hypothetical protein [KO:K01758] [EC:4.4.1.1]
KNAG_0C03690  KNAG0C03690; hypothetical protein [KO:K01754] [EC:4.3.1.19]
KNAG_0D05380  KNAG0D05380; hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
KNAG_0A01150  KNAG0A01150; hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
KNAG_0C00180  KNAG0C00180; hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
KNAG_0G01380  KNAG0G01380; hypothetical protein [KO:K20498] [EC:4.3.1.18]
KNAG_0C02960  KNAG0C02960; hypothetical protein [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kng00010  Glycolysis / Gluconeogenesis
kng00020  Citrate cycle (TCA cycle)
kng00230  Purine metabolism
kng00250  Alanine, aspartate and glutamate metabolism
kng00270  Cysteine and methionine metabolism
kng00290  Valine, leucine and isoleucine biosynthesis
kng00300  Lysine biosynthesis
kng00330  Arginine and proline metabolism
kng00460  Cyanoamino acid metabolism
kng00470  D-Amino acid metabolism
kng00564  Glycerophospholipid metabolism
kng00600  Sphingolipid metabolism
kng00620  Pyruvate metabolism
kng00630  Glyoxylate and dicarboxylate metabolism
kng00640  Propanoate metabolism
kng00680  Methane metabolism
kng00860  Porphyrin metabolism
kng00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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