KEGG   PATHWAY: kpt00330
Entry
kpt00330                    Pathway                                
Name
Arginine and proline metabolism - Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1
Class
Metabolism; Amino acid metabolism
Pathway map
kpt00330  Arginine and proline metabolism
kpt00330

Module
kpt_M00015  Proline biosynthesis, glutamate => proline [PATH:kpt00330]
kpt_M00133  Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine [PATH:kpt00330]
kpt_M00136  GABA biosynthesis, prokaryotes, putrescine => GABA [PATH:kpt00330]
kpt_M00879  Arginine succinyltransferase pathway, arginine => glutamate [PATH:kpt00330]
kpt_M00970  Proline degradation, proline => glutamate [PATH:kpt00330]
Other DBs
GO: 0006525 0006560
Organism
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816 KPPR1 [GN:kpt]
Gene
VK055_0425  creatinine amidohydrolase family protein [KO:K01470] [EC:3.5.2.10]
VK055_0427  amidohydrolase family protein [KO:K01485] [EC:3.5.4.1 3.5.4.21]
VK055_3722  amidohydrolase family protein [KO:K01485] [EC:3.5.4.1 3.5.4.21]
VK055_1902  amidohydrolase family protein [KO:K01485] [EC:3.5.4.1 3.5.4.21]
VK055_4106  speA; arginine decarboxylase [KO:K01585] [EC:4.1.1.19]
VK055_4107  speB; agmatinase [KO:K01480] [EC:3.5.3.11]
VK055_4078  orn/Lys/Arg decarboxylase, N-terminal domain protein [KO:K01581] [EC:4.1.1.17]
VK055_2442  speE; spermidine synthase [KO:K00797] [EC:2.5.1.16]
VK055_2443  speD; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
VK055_3967  ygjG; putrescine aminotransferase [KO:K09251] [EC:2.6.1.82]
VK055_0557  ydcW; 1-pyrroline dehydrogenase [KO:K00137] [EC:1.2.1.19]
VK055_0918  acetyltransferase family protein [KO:K00657] [EC:2.3.1.57]
VK055_4548  speB2; agmatinase [KO:K12255] [EC:3.5.3.7]
VK055_1015  astA; arginine N-succinyltransferase [KO:K00673] [EC:2.3.1.109]
VK055_1236  astA2; arginine N-succinyltransferase [KO:K00673] [EC:2.3.1.109]
VK055_1013  astB; succinylarginine dihydrolase [KO:K01484] [EC:3.5.3.23]
VK055_1234  astB2; succinylarginine dihydrolase [KO:K01484] [EC:3.5.3.23]
VK055_1016  astC [KO:K00840] [EC:2.6.1.81]
VK055_1237  astC [KO:K00840] [EC:2.6.1.81]
VK055_1014  astD; succinylglutamic semialdehyde dehydrogenase [KO:K06447] [EC:1.2.1.71]
VK055_1235  astD2; succinylglutamic semialdehyde dehydrogenase [KO:K06447] [EC:1.2.1.71]
VK055_1012  astE; succinylglutamate desuccinylase [KO:K05526] [EC:3.5.1.96]
VK055_1233  astE2; succinylglutamate desuccinylase [KO:K05526] [EC:3.5.1.96]
VK055_1456  puuA; &gamma-glutamylputrescine synthetase [KO:K09470] [EC:6.3.1.11]
VK055_1461  FAD binding domain protein [KO:K09471] [EC:1.4.3.-]
VK055_2006  FAD binding domain protein [KO:K09471] [EC:1.4.3.-]
VK055_1459  gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase [KO:K09472] [EC:1.2.1.99]
VK055_1457  gamma-glutamyl-gamma-aminobutyrate hydrolase [KO:K09473] [EC:3.5.1.94]
VK055_2227  proC; pyrroline-5-carboxylate reductase [KO:K00286] [EC:1.5.1.2]
VK055_1436  putA bifunctional enzyme and transcriptional regulator PutA transcriptional repressor, Proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase [KO:K13821] [EC:1.5.5.2 1.2.1.88]
VK055_2280  proB; proB [KO:K00931] [EC:2.7.2.11]
VK055_2281  proA; proA [KO:K00147] [EC:1.2.1.41]
VK055_1528  aspC; aspC [KO:K00813] [EC:2.6.1.1]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
kpt00020  Citrate cycle (TCA cycle)
kpt00220  Arginine biosynthesis
kpt00250  Alanine, aspartate and glutamate metabolism
kpt00260  Glycine, serine and threonine metabolism
kpt00270  Cysteine and methionine metabolism
kpt00310  Lysine degradation
kpt00410  beta-Alanine metabolism
kpt00470  D-Amino acid metabolism
kpt00480  Glutathione metabolism
kpt00630  Glyoxylate and dicarboxylate metabolism
kpt00650  Butanoate metabolism
kpt00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   
LinkDB

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