KEGG   PATHWAY: lak00590
Entry
lak00590                    Pathway                                
Name
Arachidonic acid metabolism - Lingula anatina
Class
Metabolism; Lipid metabolism
Pathway map
lak00590  Arachidonic acid metabolism
lak00590

Other DBs
GO: 0019369
Organism
Lingula anatina [GN:lak]
Gene
106154397  uncharacterized protein LOC106154397 [KO:K01047] [EC:3.1.1.4]
106170257  uncharacterized protein LOC106170257 [KO:K01047] [EC:3.1.1.4]
106172295  acidic phospholipase A2 PLA-1-like [KO:K01047] [EC:3.1.1.4]
106177599  basic phospholipase A2 caudoxin-like [KO:K01047] [EC:3.1.1.4]
106177600  acidic phospholipase A2 PLA-1-like [KO:K01047] [EC:3.1.1.4]
106156114  basic phospholipase A2 PA-5 [KO:K01047] [EC:3.1.1.4]
106167582  basic phospholipase A2 nigroxin B-like [KO:K01047] [EC:3.1.1.4]
106155834  group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
106162506  uncharacterized protein LOC106162506 [KO:K01047] [EC:3.1.1.4]
106169751  phospholipase A2 OS2 [KO:K01047] [EC:3.1.1.4]
106169753  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
106161399  neutral phospholipase A2 agkistrodotoxin-like [KO:K01047] [EC:3.1.1.4]
106161400  acidic phospholipase A2 PLA-1-like [KO:K01047] [EC:3.1.1.4]
106161402  neutral phospholipase A2 agkistrodotoxin-like [KO:K01047] [EC:3.1.1.4]
106161406  basic phospholipase A2 RVV-VD-like [KO:K01047] [EC:3.1.1.4]
106161407  phospholipase A2 A2-actitoxin-Cgg2a-like [KO:K01047] [EC:3.1.1.4]
106161412  acidic phospholipase A2 PLA-1-like [KO:K01047] [EC:3.1.1.4]
106169761  acidic phospholipase A2 [KO:K01047] [EC:3.1.1.4]
106174503  basic phospholipase A2 10 [KO:K01047] [EC:3.1.1.4]
106161621  basic phospholipase A2 Vb-2 [KO:K01047] [EC:3.1.1.4]
106163978  uncharacterized protein LOC106163978 [KO:K01047] [EC:3.1.1.4]
106163016  uncharacterized protein LOC106163016 [KO:K01047] [EC:3.1.1.4]
106164109  uncharacterized protein LOC106164109 [KO:K01047] [EC:3.1.1.4]
106170266  uncharacterized protein LOC106170266 [KO:K01047] [EC:3.1.1.4]
106162517  uncharacterized protein LOC106162517 [KO:K01047] [EC:3.1.1.4]
106176885  phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
106150427  phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
106157916  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
106176727  protein FAM84B-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
106178374  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
106176066  prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
106159270  prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
106156095  prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
106175694  prostamide/prostaglandin F synthase-like [KO:K15717] [EC:1.11.1.20]
106150360  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106150775  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106152774  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106175951  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
106167496  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
106167498  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
106172564  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like isoform X1 [KO:K00069] [EC:1.1.1.141]
106181763  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106182040  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106163796  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106179502  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106179529  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
106182102  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
106165584  15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
106180296  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106182024  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106173220  15-hydroxyprostaglandin dehydrogenase [NAD(+)]-like [KO:K00069] [EC:1.1.1.141]
106152123  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
106158790  uncharacterized protein LOC106158790 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
106163330  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
106164387  glutathione S-transferase 1-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
106177401  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
106176389  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
106155531  glutathione S-transferase 1 isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
106170682  hematopoietic prostaglandin D synthase isoform X2 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
106150754  allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]
106170509  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
106166490  allene oxide synthase-lipoxygenase protein [KO:K00461] [EC:1.13.11.34]
106178940  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
106157328  leukotriene A-4 hydrolase [KO:K01254] [EC:3.3.2.6]
106162485  aminopeptidase B-like [KO:K01254] [EC:3.3.2.6]
106171144  prostaglandin reductase-3-like [KO:K07119] [EC:1.3.1.48]
106152468  prostaglandin reductase 2-like [KO:K13949] [EC:1.3.1.48]
106157866  prostaglandin reductase 2-like [KO:K13949] [EC:1.3.1.48]
106167878  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
106167888  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
106167899  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
106167910  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
106170660  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
106159771  prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
106181830  glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
106181835  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
106165529  glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
106175516  glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
106176464  glutathione peroxidase-like [KO:K05361] [EC:1.11.1.12]
106176459  glutathione peroxidase-like [KO:K05361] [EC:1.11.1.12]
106157151  allene oxide synthase-lipoxygenase protein [KO:K26082] [EC:1.13.11.40 4.2.1.-]
106155495  allene oxide synthase-lipoxygenase protein-like [KO:K26082] [EC:1.13.11.40 4.2.1.-]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
KO pathway
ko00590   
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