KEGG   PATHWAY: lao00260
Entry
lao00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Lentibacillus amyloliquefaciens
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
lao00260  Glycine, serine and threonine metabolism
lao00260

Module
lao_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:lao00260]
lao_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:lao00260]
lao_M00555  Betaine biosynthesis, choline => betaine [PATH:lao00260]
lao_M00621  Glycine cleavage system [PATH:lao00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Lentibacillus amyloliquefaciens [GN:lao]
Gene
AOX59_02595  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AOX59_05080  aspartate kinase [KO:K00928] [EC:2.7.2.4]
AOX59_02590  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
AOX59_12295  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
AOX59_12285  homoserine kinase [KO:K00872] [EC:2.7.1.39]
AOX59_12290  threonine synthase [KO:K01733] [EC:4.2.3.1]
AOX59_16680  threonine synthase [KO:K01733] [EC:4.2.3.1]
AOX59_17160  threonine synthase [KO:K01733] [EC:4.2.3.1]
AOX59_16025  threonine synthase [KO:K01733] [EC:4.2.3.1]
AOX59_15670  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
AOX59_17775  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
AOX59_17935  glycerate kinase [KO:K00865] [EC:2.7.1.165]
AOX59_12175  phosphoglycerate kinase [KO:K15634] [EC:5.4.2.11]
AOX59_18615  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
AOX59_09805  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
AOX59_09810  haloacid dehalogenase [KO:K25528] [EC:3.1.3.3]
AOX59_15155  8-amino-7-oxononanoate synthase [KO:K00639] [EC:2.3.1.29]
AOX59_05260  glycine dehydrogenase [KO:K00282] [EC:1.4.4.2]
AOX59_05255  glycine dehydrogenase [KO:K00283] [EC:1.4.4.2]
AOX59_05265  glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
AOX59_01230  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AOX59_05060  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
AOX59_16275  acetoin dehydrogenase [KO:K00382] [EC:1.8.1.4]
AOX59_00220  glycine cleavage system protein H [KO:K02437]
AOX59_09935  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
AOX59_09875  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AOX59_16840  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AOX59_16520  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
AOX59_16950  homocysteine methyltransferase [KO:K00544] [EC:2.1.1.5]
AOX59_03850  sarcosine oxidase [KO:K00301] [EC:1.5.3.1]
AOX59_16895  methyltryptophan oxidase [KO:K00301] [EC:1.5.3.1]
AOX59_01730  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AOX59_01735  serine dehydratase [KO:K01752] [EC:4.3.1.17]
AOX59_17630  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
AOX59_17805  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
AOX59_04320  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
AOX59_11920  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
AOX59_11915  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
AOX59_08210  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
AOX59_08215  L-2,4-diaminobutyric acid acetyltransferase [KO:K06718] [EC:2.3.1.178]
AOX59_08205  ectC; L-ectoine synthase [KO:K06720] [EC:4.2.1.108]
AOX59_07340  ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
AOX59_17770  ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
lao00010  Glycolysis / Gluconeogenesis
lao00020  Citrate cycle (TCA cycle)
lao00230  Purine metabolism
lao00250  Alanine, aspartate and glutamate metabolism
lao00270  Cysteine and methionine metabolism
lao00290  Valine, leucine and isoleucine biosynthesis
lao00300  Lysine biosynthesis
lao00330  Arginine and proline metabolism
lao00460  Cyanoamino acid metabolism
lao00470  D-Amino acid metabolism
lao00564  Glycerophospholipid metabolism
lao00620  Pyruvate metabolism
lao00630  Glyoxylate and dicarboxylate metabolism
lao00640  Propanoate metabolism
lao00680  Methane metabolism
lao00860  Porphyrin metabolism
lao00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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