KEGG   PATHWAY: lbb00260
Entry
lbb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Lycium barbarum (goji berry)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
lbb00260  Glycine, serine and threonine metabolism
lbb00260

Module
lbb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:lbb00260]
lbb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:lbb00260]
lbb_M00555  Betaine biosynthesis, choline => betaine [PATH:lbb00260]
lbb_M00621  Glycine cleavage system [PATH:lbb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Lycium barbarum (goji berry) [GN:lbb]
Gene
132625855  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
132606210  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
132644688  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
132625856  uncharacterized protein LOC132625856 [KO:K00133] [EC:1.2.1.11]
132614124  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
132633496  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
132645427  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
132613360  LOW QUALITY PROTEIN: low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
132598683  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
132635878  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
132604223  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
132604224  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
132621975  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
132622129  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
132604393  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
132624356  uncharacterized protein LOC132624356 [KO:K00600] [EC:2.1.2.1]
132640761  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
132606362  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
132627669  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
132604582  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
132599335  glycerate dehydrogenase HPR, peroxisomal [KO:K15893] [EC:1.1.1.29]
132645630  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
132645631  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
132617493  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
132634998  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
132615331  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1-like isoform X1 [KO:K01834] [EC:5.4.2.11]
132627462  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
132623384  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
132620330  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
132633363  D-glycerate 3-kinase, chloroplastic [KO:K15918] [EC:2.7.1.31]
132631371  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
132633577  D-3-phosphoglycerate dehydrogenase 2, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
132606503  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
132621840  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
132605899  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
132611042  amine oxidase [copper-containing] alpha 3, peroxisomal-like [KO:K00276] [EC:1.4.3.21]
132611043  primary amine oxidase 1-like isoform X1 [KO:K00276] [EC:1.4.3.21]
132635052  amine oxidase [copper-containing] gamma 2-like [KO:K00276] [EC:1.4.3.21]
132601628  diamine oxidase [copper-containing] 1, peroxisomal-like isoform X1 [KO:K00276] [EC:1.4.3.21]
132601647  diamine oxidase [copper-containing] 1, peroxisomal isoform X1 [KO:K00276] [EC:1.4.3.21]
132618551  primary amine oxidase 1-like [KO:K00276] [EC:1.4.3.21]
132636385  amine oxidase [copper-containing] alpha 3, peroxisomal-like [KO:K00276] [EC:1.4.3.21]
132641132  diamine oxidase [copper-containing] 1, peroxisomal-like [KO:K00276] [EC:1.4.3.21]
132635899  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
132621590  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
132598429  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
132604479  dihydrolipoyl dehydrogenase 2, mitochondrial [KO:K00382] [EC:1.8.1.4]
132640319  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
132640331  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
132622821  glycine cleavage system H protein 2, mitochondrial isoform X1 [KO:K02437]
132640629  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
132606284  glycine cleavage system H protein 2, mitochondrial-like [KO:K02437]
132609748  glycine cleavage system H protein 3, mitochondrial-like [KO:K02437]
132613893  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
132606756  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
132624683  glutamate--glyoxylate aminotransferase 2-like [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
132625552  glutamate--glyoxylate aminotransferase 2 isoform X1 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
132641124  glutamate--glyoxylate aminotransferase 2-like [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
132603183  choline monooxygenase, chloroplastic isoform X1 [KO:K00499] [EC:1.14.15.7]
132632757  aminoaldehyde dehydrogenase 2-like [KO:K00130] [EC:1.2.1.8]
132632758  aminoaldehyde dehydrogenase 2 [KO:K00130] [EC:1.2.1.8]
132601245  aminoaldehyde dehydrogenase 1 [KO:K00130] [EC:1.2.1.8]
132610006  aldehyde dehydrogenase family 7 member A1-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
132633524  aldehyde dehydrogenase family 7 member A1 isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
132609499  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
132629953  threonine dehydratase-like [KO:K01754] [EC:4.3.1.19]
132605343  threonine dehydratase 1 biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
132607149  threonine dehydratase 1 biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
132609892  serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
132645182  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
132628278  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
132631764  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
132618724  tryptophan synthase beta chain 2, chloroplastic [KO:K01696] [EC:4.2.1.20]
132604258  uncharacterized protein LOC132604258 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
lbb00010  Glycolysis / Gluconeogenesis
lbb00020  Citrate cycle (TCA cycle)
lbb00230  Purine metabolism
lbb00250  Alanine, aspartate and glutamate metabolism
lbb00270  Cysteine and methionine metabolism
lbb00290  Valine, leucine and isoleucine biosynthesis
lbb00300  Lysine biosynthesis
lbb00330  Arginine and proline metabolism
lbb00460  Cyanoamino acid metabolism
lbb00470  D-Amino acid metabolism
lbb00564  Glycerophospholipid metabolism
lbb00600  Sphingolipid metabolism
lbb00620  Pyruvate metabolism
lbb00630  Glyoxylate and dicarboxylate metabolism
lbb00640  Propanoate metabolism
lbb00860  Porphyrin metabolism
lbb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system