KEGG   PATHWAY: lel00260
Entry
lel00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Lodderomyces elongisporus
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
lel00260  Glycine, serine and threonine metabolism
lel00260

Module
lel_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:lel00260]
lel_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:lel00260]
lel_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:lel00260]
lel_M00621  Glycine cleavage system [PATH:lel00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Lodderomyces elongisporus [GN:lel]
Gene
PVL30_004400  HOM3; Aspartokinase [KO:K00928] [EC:2.7.2.4]
PVL30_000722  HOM2; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
PVL30_001573  HOM6; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PVL30_004567  THR1; Trihydroxynaphthalene reductase [KO:K00872] [EC:2.7.1.39]
PVL30_004508  THR4; threonine synthase [KO:K01733] [EC:4.2.3.1]
PVL30_000318  GLY1_1; Threonine aldolase [KO:K01620] [EC:4.1.2.48]
PVL30_002744  GLY1_3; Threonine aldolase [KO:K01620] [EC:4.1.2.48]
PVL30_005292  SHM1; glycine hydroxymethyltransferase shm1 [KO:K00600] [EC:2.1.2.1]
PVL30_005670  SHM2; Serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
PVL30_005703  uncharacterized protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
PVL30_001285  GPM1; Phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
PVL30_001645  GPM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
PVL30_002405  uncharacterized protein [KO:K15918] [EC:2.7.1.31]
PVL30_000433  SER3; Phosphoglycerate dehydrogenase ser3 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PVL30_001846  SER1; Phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
PVL30_001054  SER2; Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
PVL30_003978  uncharacterized protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
PVL30_000116  HEM1; mitochondrial 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
PVL30_001261  AMO1; peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
PVL30_001881  AMO2; Cytochrome c oxidase subunit 1 [KO:K00276] [EC:1.4.3.21]
PVL30_000563  GCV2; glycine decarboxylase subunit P [KO:K00281] [EC:1.4.4.2]
PVL30_005534  GCV1; Aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
PVL30_002650  LPD1; dihydrolipoamide dehydrogenase precursor [KO:K00382] [EC:1.8.1.4]
PVL30_003038  GCV3; glycine cleavage system H-protein subunit [KO:K02437]
PVL30_001547  DAO1; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
PVL30_004205  uncharacterized protein [KO:K00273] [EC:1.4.3.3]
PVL30_000767  CHO1; CDP-diacylglycerol-serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
PVL30_001564  CYS4; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
PVL30_002551  CYS3; cystathionine gamma-lyase cys3 [KO:K01758] [EC:4.4.1.1]
PVL30_001844  ILV1; threonine deaminase [KO:K01754] [EC:4.3.1.19]
PVL30_001117  CHA1_1; catabolic L-serine/threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PVL30_003556  CHA1_2; catabolic L-serine/threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PVL30_004240  TRP5; tryptophan synthetase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
lel00010  Glycolysis / Gluconeogenesis
lel00020  Citrate cycle (TCA cycle)
lel00230  Purine metabolism
lel00250  Alanine, aspartate and glutamate metabolism
lel00270  Cysteine and methionine metabolism
lel00290  Valine, leucine and isoleucine biosynthesis
lel00300  Lysine biosynthesis
lel00330  Arginine and proline metabolism
lel00460  Cyanoamino acid metabolism
lel00470  D-Amino acid metabolism
lel00564  Glycerophospholipid metabolism
lel00600  Sphingolipid metabolism
lel00620  Pyruvate metabolism
lel00630  Glyoxylate and dicarboxylate metabolism
lel00640  Propanoate metabolism
lel00680  Methane metabolism
lel00860  Porphyrin metabolism
lel00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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