KEGG   PATHWAY: maf00630
Entry
maf00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium tuberculosis variant africanum
Class
Metabolism; Carbohydrate metabolism
Pathway map
maf00630  Glyoxylate and dicarboxylate metabolism
maf00630

Module
maf_M00012  Glyoxylate cycle [PATH:maf00630]
maf_M00621  Glycine cleavage system [PATH:maf00630]
maf_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:maf00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium tuberculosis variant africanum [GN:maf]
Gene
MAF_04700  icl; isocitrate lyase Icl [KO:K01637] [EC:4.1.3.1]
MAF_19380  aceAa; putative isocitrate lyase ACEAA [first part] (isocitrase) [KO:K01637] [EC:4.1.3.1]
MAF_19390  aceAb; putative isocitrate lyase ACEAB [second part] (isocitrase) [KO:K01637] [EC:4.1.3.1]
MAF_36740  acs; acetyl-coenzyme A synthetase ACS (acetate--CoA ligase) [KO:K01895] [EC:6.2.1.1]
MAF_18590  glcB; putative MALATE synthase G GLCB [KO:K01638] [EC:2.3.3.9]
MAF_12590  mdh; putative malate dehydrogenase MDH [KO:K00024] [EC:1.1.1.37]
MAF_11470  gltA1; putative citrate synthase I GLTA1 [KO:K01647] [EC:2.3.3.1]
MAF_08980  citA; putative citrate synthase II CITA [KO:K01647] [EC:2.3.3.1]
MAF_09050  gltA2; putative citrate synthase I GLTA2 [KO:K01647] [EC:2.3.3.1]
MAF_14980  acn; putative iron-regulated aconitate hydratase ACN (citrate hydro-lyase) [KO:K01681] [EC:4.2.1.3]
MAF_02440  fadA2; putative acetyl-CoA acyltransferase fada2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) [KO:K00626] [EC:2.3.1.9]
MAF_08680  fadA; putative acyl-CoA thiolase FADA [KO:K00626] [EC:2.3.1.9]
MAF_10870  fadA3; putative beta-ketoacyl CoA thiolase FADA3 [KO:K00626] [EC:2.3.1.9]
MAF_09230  putative lipid carrier protein or keto acyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MAF_13470  fadA4; putative acetyl-CoA acetyltransferase FADA4 (acetoacetyl-CoA thiolase) [KO:K00626] [EC:2.3.1.9]
MAF_18890  conserved hypothetical protein [KO:K00626] [EC:2.3.1.9]
MAF_35580  fadA5; putative acetyl-CoA acetyltransferase FADA5 (acetoacetyl-CoA thiolase) [KO:K00626] [EC:2.3.1.9]
MAF_35680  fadA6; putative acetyl-CoA acetyltransferase FADA6 (acetoacetyl-CoA thiolase) [KO:K00626] [EC:2.3.1.9]
MAF_35350  ltp3; putative lipid carrier protein or keto acyl-CoA thiolase LTP3 [KO:K00626] [EC:2.3.1.9]
MAF_13460  conserved hypothetical protein [KO:K05606] [EC:5.1.99.1]
MAF_32960  accA3; putative bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) ACCA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP) [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
MAF_32910  accD5; putative propionyl-CoA carboxylase beta chain 5 ACCD5 (PCCASE) (propanoyl-CoA:carbon dioxide ligase) [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
MAF_22580  accD6; acetyl/propionyl-CoA carboxylase (beta subunit) ACCD6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
MAF_15160  mutA; putative methylmalonyl-CoA mutase small subunit MUTA (MCM) [KO:K01847] [EC:5.4.99.2]
MAF_15170  mutB; putative methylmalonyl-CoA mutase large subunit MUTB (MCM) [KO:K01847] [EC:5.4.99.2]
MAF_12760  putative oxidoreductase [KO:K00104] [EC:1.1.99.14]
MAF_22880  putative dehydrogenase [KO:K00104] [EC:1.1.99.14]
MAF_19000  glnA3; putative Glutamine synthetase GLNA3 (Glutamine synthase) [KO:K01915] [EC:6.3.1.2]
MAF_22320  glnA1; Glutamine synthetase GLNA1 (Glutamine synthase) [KO:K01915] [EC:6.3.1.2]
MAF_22340  glnA2; putative Glutamine synthetase GLNA2 (Glutamine synthase) [KO:K01915] [EC:6.3.1.2]
MAF_28650  glnA4; putative glutamine synthetase GLNA4 (glutamine synthase) [KO:K01915] [EC:6.3.1.2]
MAF_00700  glyA2; putative serine hydroxymethyltransferase GlyA2 [KO:K00600] [EC:2.1.2.1]
MAF_11080  glyA1; putative serine hydroxymethyltransferase 1 glyA1 [KO:K00600] [EC:2.1.2.1]
MAF_18540  gcvB; putative glycine dehydrogenase gcvB (glycine decarboxylase) (glycine cleavage system P-protein) [KO:K00281] [EC:1.4.4.2]
MAF_22220  gcvT; putative aminomethyltransferase GcvT (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
MAF_04650  lpd; dihydrolipoamide dehydrogenase LPD (LIPOAMIDE reductase (NADH)) [KO:K00382] [EC:1.8.1.4]
MAF_18480  gcvH; putative Glycine cleavage system H protein GCVH [KO:K02437]
MAF_22160  conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
MAF_12670  sucA; putative 2-oxoglutarate dehydrogenase SUCA (alpha-ketoglutarate dehydrogenase) [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
MAF_29690  purU; putative formyltetrahydrofolate deformylase PURU (formyl-FH(4) hydrolase) [KO:K01433] [EC:3.5.1.10]
MAF_01190  oxcA; putative OXALYL-CoA DECARBOXYLASE OXCA [KO:K01577] [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
maf00010  Glycolysis / Gluconeogenesis
maf00020  Citrate cycle (TCA cycle)
maf00030  Pentose phosphate pathway
maf00053  Ascorbate and aldarate metabolism
maf00071  Fatty acid degradation
maf00230  Purine metabolism
maf00250  Alanine, aspartate and glutamate metabolism
maf00260  Glycine, serine and threonine metabolism
maf00620  Pyruvate metabolism
maf00710  Carbon fixation by Calvin cycle
maf00750  Vitamin B6 metabolism
maf00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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