KEGG   PATHWAY: mch00630
Entry
mch00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Methylorubrum extorquens CM4
Class
Metabolism; Carbohydrate metabolism
Pathway map
mch00630  Glyoxylate and dicarboxylate metabolism
mch00630

Module
mch_M00621  Glycine cleavage system [PATH:mch00630]
mch_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mch00630]
Other DBs
GO: 0046487 0043648
Organism
Methylorubrum extorquens CM4 [GN:mch]
Gene
Mchl_4898  AMP-dependent synthetase and ligase [KO:K01895] [EC:6.2.1.1]
Mchl_2785  acetate/CoA ligase [KO:K01895] [EC:6.2.1.1]
Mchl_1925  malate dehydrogenase, NAD-dependent [KO:K00024] [EC:1.1.1.37]
Mchl_5145  citrate synthase I [KO:K01647] [EC:2.3.3.1]
Mchl_2862  aconitate hydratase 1 [KO:K27802] [EC:4.2.1.3 4.2.1.99]
Mchl_2136  succinyl-CoA synthetase, alpha subunit [KO:K08692] [EC:6.2.1.9]
Mchl_2135  succinyl-CoA synthetase, beta subunit [KO:K14067] [EC:6.2.1.9]
Mchl_3568  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Mchl_3777  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Mchl_3778  acetoacetyl-CoA reductase [KO:K00023] [EC:1.1.1.36]
Mchl_3753  MaoC domain protein dehydratase [KO:K17865] [EC:4.2.1.55]
Mchl_0332  crotonyl-CoA reductase [KO:K14446] [EC:1.3.1.85]
Mchl_1198  methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
Mchl_0334  methylmalonyl-CoA mutase, large subunit [KO:K14447] [EC:5.4.99.63]
Mchl_2504  acyl-CoA dehydrogenase domain protein [KO:K14448] [EC:1.3.8.12]
Mchl_4075  MaoC domain protein dehydratase [KO:K14449] [EC:4.2.1.148]
Mchl_2138  Citrate (pro-3S)-lyase [KO:K08691] [EC:4.1.3.24 4.1.3.25]
Mchl_4285  HpcH/HpaI aldolase [KO:K08691] [EC:4.1.3.24 4.1.3.25]
Mchl_3221  Carbamoyl-phosphate synthase L chain ATP-binding [KO:K01965] [EC:6.4.1.3]
Mchl_0326  carboxyl transferase [KO:K01966] [EC:6.4.1.3 2.1.3.15]
Mchl_5261  methylmalonyl-CoA mutase, large subunit [KO:K01847] [EC:5.4.99.2]
Mchl_2665  Methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
Mchl_0884  FAD linked oxidase domain protein [KO:K00104] [EC:1.1.99.14]
Mchl_5254  FAD linked oxidase domain protein [KO:K11472] [EC:1.1.99.14]
Mchl_3475  protein of unknown function DUF224 cysteine-rich region domain protein [KO:K11473] [EC:1.1.99.14]
Mchl_0333  Catalase [KO:K03781] [EC:1.11.1.6]
Mchl_3534  Catalase [KO:K03781] [EC:1.11.1.6]
Mchl_0174  Catalase domain protein [KO:K03781] [EC:1.11.1.6]
Mchl_2589  Catalase domain protein [KO:K03781] [EC:1.11.1.6]
Mchl_0454  Glyoxylate reductase [KO:K00015] [EC:1.1.1.26]
Mchl_2132  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding [KO:K00018] [EC:1.1.1.29]
Mchl_0323  HAD-superfamily hydrolase, subfamily IA, variant 1 [KO:K01091] [EC:3.1.3.18]
Mchl_2571  phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
Mchl_2324  HAD-superfamily hydrolase, subfamily IA, variant 1 [KO:K01091] [EC:3.1.3.18]
Mchl_2131  aminotransferase class V [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Mchl_4570  Serine--glyoxylate transaminase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
Mchl_2653  Glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
Mchl_2654  glutamine synthetase, type I [KO:K01915] [EC:6.3.1.2]
Mchl_4021  glutamine synthetase, type III [KO:K01915] [EC:6.3.1.2]
Mchl_3495  Glycine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
Mchl_0812  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
Mchl_0814  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
Mchl_4448  FAD-dependent pyridine nucleotide-disulphide oxidoreductase [KO:K00382] [EC:1.8.1.4]
Mchl_1930  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Mchl_3018  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
Mchl_0813  glycine cleavage system H protein [KO:K02437]
Mchl_4572  hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
Mchl_5683  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Mchl_2974  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Mchl_1042  Hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
Mchl_5152  tartrate dehydrogenase [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
Mchl_2283  2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
Mchl_0371  bicupin, oxalate decarboxylase family [KO:K01569] [EC:4.1.1.2]
Mchl_4870  conserved hypothetical protein [KO:K00126] [EC:1.17.1.9]
Mchl_0421  molybdopterin oxidoreductase [KO:K00123] [EC:1.17.1.9]
Mchl_4869  formate dehydrogenase, alpha subunit [KO:K00123] [EC:1.17.1.9]
Mchl_5043  formate dehydrogenase, alpha subunit [KO:K00123] [EC:1.17.1.9]
Mchl_5042  Respiratory-chain NADH dehydrogenase domain 51 kDa subunit [KO:K22515] [EC:1.17.1.9]
Mchl_0422  4Fe-4S ferredoxin iron-sulfur binding domain protein [KO:K00124]
Mchl_4868  NADH dehydrogenase (quinone) [KO:K00124]
Mchl_0423  formate dehydrogenase, gamma subunit [KO:K00127]
Mchl_4867  NADH dehydrogenase (ubiquinone) 24 kDa subunit [KO:K00127]
Mchl_1263  conserved hypothetical protein [KO:K01432] [EC:3.5.1.9]
Mchl_5699  formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
Mchl_2023  Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase [KO:K01455] [EC:3.5.1.49]
Mchl_3684  Formamidase [KO:K01455] [EC:3.5.1.49]
Mchl_2417  AMP-dependent synthetase and ligase [KO:K22133] [EC:6.2.1.8]
Mchl_1369  oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
Mchl_1367  formyl-CoA transferase [KO:K07749] [EC:2.8.3.16]
Mchl_1378  formyl-CoA transferase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mch00010  Glycolysis / Gluconeogenesis
mch00020  Citrate cycle (TCA cycle)
mch00030  Pentose phosphate pathway
mch00053  Ascorbate and aldarate metabolism
mch00071  Fatty acid degradation
mch00230  Purine metabolism
mch00250  Alanine, aspartate and glutamate metabolism
mch00260  Glycine, serine and threonine metabolism
mch00620  Pyruvate metabolism
mch00710  Carbon fixation by Calvin cycle
mch00750  Vitamin B6 metabolism
mch00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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