KEGG   PATHWAY: mhaz00010
Entry
mhaz00010                   Pathway                                
Name
Glycolysis / Gluconeogenesis - Methanohalophilus halophilus
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
mhaz00010  Glycolysis / Gluconeogenesis
mhaz00010

Module
mhaz_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:mhaz00010]
mhaz_M00002  Glycolysis, core module involving three-carbon compounds [PATH:mhaz00010]
mhaz_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mhaz00010]
Other DBs
GO: 0006096 0006094
Organism
Methanohalophilus halophilus [GN:mhaz]
Gene
BHR79_04635  glucose-6-phosphate isomerase [KO:K06859] [EC:5.3.1.9]
BHR79_05490  ADP-specific phosphofructokinase [KO:K00918] [EC:2.7.1.146 2.7.1.147]
BHR79_05495  hypothetical protein [KO:K00918] [EC:2.7.1.146 2.7.1.147]
BHR79_05430  fructose-bisphosphatase, class II [KO:K02446] [EC:3.1.3.11]
BHR79_02475  fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
BHR79_10150  fructose-bisphosphate aldolase [KO:K16306] [EC:4.1.2.13 2.2.1.10]
BHR79_02305  fructose-bisphosphate aldolase [KO:K16306] [EC:4.1.2.13 2.2.1.10]
BHR79_02335  triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
BHR79_07740  glyceraldehyde-3-phosphate dehydrogenase [KO:K00150] [EC:1.2.1.59]
BHR79_05460  phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
BHR79_04430  phosphoglycerate mutase (2,3-diphosphoglycerate-independent) [KO:K15633] [EC:5.4.2.12]
BHR79_02395  cofactor-independent phosphoglycerate mutase [KO:K15635] [EC:5.4.2.12]
BHR79_03685  phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
BHR79_08970  pyruvate kinase [KO:K00873] [EC:2.7.1.40]
BHR79_00115  pyruvate, phosphate dikinase [KO:K01006] [EC:2.7.9.1]
BHR79_08585  phosphoenolpyruvate synthase [KO:K01007] [EC:2.7.9.2]
BHR79_01740  porA; pyruvate ferredoxin oxidoreductase [KO:K00169] [EC:1.2.7.1]
BHR79_01735  pyruvate ferredoxin oxidoreductase [KO:K00170] [EC:1.2.7.1]
BHR79_01750  pyruvate ferredoxin oxidoreductase [KO:K00172] [EC:1.2.7.1]
BHR79_01745  pyruvate synthase [KO:K00171] [EC:1.2.7.1]
BHR79_00695  2-oxoacid:ferredoxin oxidoreductase subunit alpha [KO:K00174] [EC:1.2.7.3 1.2.7.11]
BHR79_00690  2-oxoacid ferredoxin oxidoreductase [KO:K00175] [EC:1.2.7.3 1.2.7.11]
BHR79_08525  acetyl-CoA synthetase [KO:K01895] [EC:6.2.1.1]
BHR79_06785  acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
BHR79_05450  acyl-CoA synthetase [KO:K24012] [EC:6.2.1.13]
BHR79_01995  phosphoglucosamine mutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
mhaz00020  Citrate cycle (TCA cycle)
mhaz00030  Pentose phosphate pathway
mhaz00500  Starch and sucrose metabolism
mhaz00620  Pyruvate metabolism
mhaz00640  Propanoate metabolism
mhaz00710  Carbon fixation by Calvin cycle
KO pathway
ko00010   
LinkDB

DBGET integrated database retrieval system