PATHWAY: mleu04940 Help
Entry Name Type I diabetes mellitus - Mandrillus leucophaeus (drill)
Description Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).
Class Human Diseases; Endocrine and metabolic diseaseBRITE hierarchy
Pathway map Ortholog table Organism Mandrillus leucophaeus (drill) [GN:
mleu ]
Gene 105540228 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 [KO:K06752 ]
105540229 HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752 ]
105540230 LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752 ]
105553177 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1 [KO:K06752 ]
105540670 HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752 ]
105536146 HLA class II histocompatibility antigen, DRB1-15 beta chain isoform X1 [KO:K06752 ]
105536147 HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752 ]
105536148 HLA class II histocompatibility antigen, DR beta 3 chain-like [KO:K06752 ]
105536618 mamu class II histocompatibility antigen, DR alpha chain isoform X1 [KO:K06752 ]
105537163 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
105537709 HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752 ]
105537711 HLA class II histocompatibility antigen, DRB1-1 beta chain isoform X1 [KO:K06752 ]
105537712 HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752 ]
105531108 HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752 ]
105531110 HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752 ]
105531112 HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752 ]
105531113 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
105531120 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
105531121 HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752 ]
105533201 CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413 ]
105548458 CD28; T-cell-specific surface glycoprotein CD28 isoform X1 [KO:K06470 ]
105533269 class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751 ]
105540194 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, B-67 alpha chain-like [KO:K06751 ]
105553110 LOW QUALITY PROTEIN: patr class I histocompatibility antigen, alpha chain E [KO:K06751 ]
105533649 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751 ]
105533654 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751 ]
105541160 LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751 ]
105554853 patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751 ]
105535298 mamu class I histocompatibility antigen, alpha chain F isoform X1 [KO:K06751 ]
105536048 HLA class I histocompatibility antigen, B-14 alpha chain isoform X1 [KO:K06751 ]
105550871 HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751 ]
105550892 LOW QUALITY PROTEIN: uncharacterized protein LOC105550892 [KO:K06751 ]
105554126 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
105552455 FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
Compound Reference Authors Rabinovitch A, Suarez-Pinzon WL.
Title Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus.
Journal Reference Authors Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS, Todd JA, Concannon P
Title Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.
Journal Reference Authors Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SC, Jenkins SC, Palmer SM, et al.
Title A genome-wide search for human type 1 diabetes susceptibility genes.
Journal Reference Authors Fujisawa T, Ikegami H, Kawaguchi Y, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Shima K, Ogihara T.
Title Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM.
Journal Reference Authors Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H.
Title Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase.
Journal Reference Authors Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS.
Title Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.
Journal Reference Authors Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA.
Title Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.
Journal Reference Authors Lieberman SM, DiLorenzo TP.
Title A comprehensive guide to antibody and T-cell responses in type 1 diabetes.
Journal Reference Authors Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC.
Title Granzyme B: a natural born killer.
Journal Related KO pathway LinkDB All DBs
