KEGG   ORTHOLOGY: K04389
Entry
K04389                      KO                                     

Symbol
TNFSF6, FASL, CD178
Name
tumor necrosis factor ligand superfamily member 6
Pathway
map01524  Platinum drug resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04060  Cytokine-cytokine receptor interaction
map04068  FoxO signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04217  Necroptosis
map04650  Natural killer cell mediated cytotoxicity
map04722  Neurotrophin signaling pathway
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map04940  Type I diabetes mellitus
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05142  Chagas disease
map05143  African trypanosomiasis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05168  Herpes simplex virus 1 infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05320  Autoimmune thyroid disease
map05330  Allograft rejection
map05332  Graft-versus-host disease
map05417  Lipid and atherosclerosis
Disease
H00108  Autoimmune lymphoproliferative syndromes
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04014 Ras signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04068 FoxO signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04151 PI3K-Akt signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04217 Necroptosis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05205 Proteoglycans in cancer
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05161 Hepatitis B
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05160 Hepatitis C
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05164 Influenza A
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05162 Measles
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05168 Herpes simplex virus 1 infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05163 Human cytomegalovirus infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05165 Human papillomavirus infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05143 African trypanosomiasis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09163 Immune disease
   05320 Autoimmune thyroid disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05330 Allograft rejection
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   05332 Graft-versus-host disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09164 Neurodegenerative disease
   05022 Pathways of neurodegeneration - multiple diseases
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09167 Endocrine and metabolic disease
   04940 Type I diabetes mellitus
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04936 Alcoholic liver disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04932 Non-alcoholic fatty liver disease
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04052 Cytokines and growth factors
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
   04090 CD molecules
    K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
Cytokines and growth factors [BR:ko04052]
 Cytokines
  Tumor necrosis fators
   K04389  TNFSF6, FASL, CD178; tumor necrosis factor ligand superfamily member 6
CD molecules [BR:ko04090]
 Proteins
  K04389  CD178, FASLG; tumor necrosis factor (ligand) superfamily, member 6
Other DBs
GO: 0005164
Genes
HSA: 356(FASLG)
PTR: 469584(FASLG)
PPS: 100970360(FASLG)
GGO: 101137781(FASLG)
PON: 100461418(FASLG)
NLE: 100597719(FASLG)
MCC: 574159(FASLG)
MCF: 102139406(FASLG)
CSAB: 103230577(FASLG)
CATY: 105597557(FASLG)
PANU: 101000210(FASLG)
RRO: 104669600(FASLG)
RBB: 108526259(FASLG)
TFN: 117074605(FASLG)
PTEH: 111539343(FASLG)
CJC: 100404850(FASLG)
SBQ: 101035660(FASLG)
MMUR: 105871667(FASLG)
MMU: 14103(Fasl)
MCAL: 110300709(Faslg)
MPAH: 110322215(Faslg)
RNO: 25385(Faslg)
MCOC: 116070785(Faslg)
MUN: 110556827(Faslg)
CGE: 100773293(Faslg)
PLEU: 114689971(Faslg)
NGI: 103740694(Faslg)
HGL: 101698642(Faslg)
CPOC: 100714139(Faslg)
CCAN: 109689125(Faslg)
OCU: 100344073(FASLG)
OPI: 101528266(FASLG)
TUP: 102502878(FASLG)
CFA: 442968(FASLG)
VVP: 112921762(FASLG)
VLG: 121498932(FASLG)
AML: 100468235(FASLG)
UMR: 103668115(FASLG)
UAH: 113262825(FASLG)
ORO: 101381319(FASLG)
MPUF: 101687517(FASLG)
EJU: 114223997(FASLG)
MLX: 118014469(FASLG)
FCA: 493945(FASLG)
PYU: 121015025(FASLG)
PBG: 122476073(FASLG)
PTG: 102953222(FASLG)
PPAD: 109252525(FASLG)
AJU: 106979842(FASLG)
HHV: 120224200(FASLG)
BTA: 407111(FASLG)
BOM: 102281889(FASLG)
BIU: 109570480 109570785(FASLG)
BBUB: 102404535(FASLG)
CHX: 102178753(FASLG)
OAS: 100135696(FASLG)
ODA: 120880243(FASLG)
CCAD: 122452409(FASLG)
SSC: 396726(FASLG)
CFR: 102503604(FASLG)
CBAI: 105070302(FASLG)
CDK: 105092770(FASLG)
BACU: 102999836(FASLG)
LVE: 103073066(FASLG)
OOR: 101272436(FASLG)
DLE: 111170265(FASLG)
PCAD: 102979864(FASLG)
PSIU: 116739025(FASLG)
ECB: 100052326(FASLG)
EPZ: 103554252(FASLG)
EAI: 106838669(FASLG)
MYB: 102262076(FASLG)
MYD: 102759597(FASLG)
MMYO: 118673639(FASLG)
MLF: 102439228(FASLG)
MNA: 107543787(FASLG)
PKL: 118721567(FASLG)
HAI: 109385146(FASLG)
DRO: 112297049(FASLG)
SHON: 118979183(FASLG)
AJM: 119065454(FASLG)
PDIC: 114512032(FASLG)
MMF: 118637768(FASLG)
RFQ: 117014309(FASLG)
PALE: 102883204(FASLG)
PGIG: 120617668(FASLG)
RAY: 107512052(FASLG)
MJV: 108401438(FASLG)
TOD: 119240071(FASLG)
LAV: 100662586(FASLG)
TMU: 101344408
GAS: 123245896(FASLG)
SHR: 100919776(FASLG)
PCW: 110197002(FASLG)
OAA: 100081646(FASLG)
GGA: 429064(FASLG)
PCOC: 116230501(FASLG)
MGP: 100551315(FASLG)
NMEL: 110402693(FASLG)
APLA: 101801884(FASLG)
ACYG: 106041569(FASLG)
TGU: 100230435(FASLG)
LSR: 110478980(FASLG)
SCAN: 103823387(FASLG)
PMOA: 120512233(FASLG)
OTC: 121344224(FASLG)
PRUF: 121359744(FASLG)
GFR: 102045588(FASLG)
FAB: 101820749(FASLG)
PHI: 102107854(FASLG)
PMAJ: 107207877(FASLG)
CCAE: 111932669(FASLG)
CCW: 104695445(FASLG)
ETL: 114063951(FASLG)
FPG: 101922036(FASLG)
FCH: 102046752(FASLG)
CLV: 102097854(FASLG)
EGZ: 104132069(FASLG)
NNI: 104010400(FASLG)
ACUN: 113483045(FASLG)
PADL: 103914004(FASLG)
AAM: 106499698(FASLG)
AROW: 112977130(FASLG)
NPD: 112951177(FASLG)
DNE: 112997421(FASLG)
AMJ: 102564044(FASLG)
CPOO: 109306951(FASLG)
GGN: 109305351(FASLG)
PSS: 102460695(FASLG)
CMY: 102937724(FASLG)
CPIC: 101951265(FASLG)
TST: 117882288(FASLG)
CABI: 116822232(FASLG)
MRV: 120370739(FASLG)
ACS: 100554702(faslg)
PVT: 110089831(FASLG)
SUND: 121927998(FASLG)
PBI: 103051809
PMUR: 107290564(FASLG)
TSR: 106553443
PGUT: 117661286(FASLG)
VKO: 123028014(FASLG)
PMUA: 114598486(FASLG)
ZVI: 118078298(FASLG)
GJA: 107115985
XLA: 100192357(faslg.L) 108715004(faslg.S)
XTR: 100124789(faslg)
NPR: 108795559(FASLG)
DRE: 735295(faslg)
IPU: 108257517(faslg)
PHYP: 113545312(faslg)
AMEX: 103027441
EEE: 113589104
NCC: 104964064(faslg)
CGOB: 115007592(faslg) 115014829
ELY: 117253399(faslg) 117261369(cd40lg)
PLEP: 121948288(cd40lg) 121965450(faslg)
SLUC: 116052328(cd40lg) 116058891(faslg)
ECRA: 117949987(faslg) 117951831(cd40lg)
PFLV: 114563150
GAT: 120816898(cd40lg) 120823431(faslg)
PPUG: 119210096(cd40lg) 119217173(faslg)
MSAM: 119888531(cd40lg) 119901000(faslg)
CUD: 121511949(faslg) 121516645(cd40lg)
OAU: 116317586(cd40lg) 116331186(faslg)
OML: 112150637 112153304(cd40lg)
XCO: 114139005 114150361(faslg)
GAF: 122837358(cd40lg) 122839075(faslg)
CTUL: 119786254(cd40lg) 119799270(faslg)
KMR: 108230718(faslg) 108231281(cd40lg)
ALIM: 106512210
POV: 109625570
SSEN: 122762115(faslg) 122778162(cd40lg)
HHIP: 117760140(faslg) 117769667(cd40lg)
XGL: 120785458(cd40lg) 120790939(faslg)
BPEC: 110154839(faslg) 110158999
ELS: 105011736(faslg) 105014159
PKI: 111834820
AANG: 118224955(faslg)
LOC: 102682852(faslg)
PSPA: 121326429(faslg) 121330683
ARUT: 117411359(faslg)
LCM: 102361141 102366280(FASLG)
BBEL: 109472475
CBR: CBG_25915
MYI: 110463627
DGT: 114535707
 » show all
Reference
PMID:7528780
  Authors
Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH
  Title
Fas ligand mediates activation-induced cell death in human T lymphocytes.
  Journal
J Exp Med 181:71-7 (1995)
DOI:10.1084/jem.181.1.71
  Sequence
[hsa:356]
Reference
  Authors
Kirkin V, Cahuzac N, Guardiola-Serrano F, Huault S, Luckerath K, Friedmann E, Novac N, Wels WS, Martoglio B, Hueber AO, Zornig M
  Title
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.
  Journal
Cell Death Differ 14:1678-87 (2007)
DOI:10.1038/sj.cdd.4402175
  Sequence
[hsa:356]
Reference
PMID:7826947
  Authors
Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S
  Title
Human Fas ligand: gene structure, chromosomal location and species specificity.
  Journal
Int Immunol 6:1567-74 (1994)
DOI:10.1093/intimm/6.10.1567
  Sequence
[hsa:356]
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