KEGG   PATHWAY: mmur00980
Entry
mmur00980                   Pathway                                
Name
Metabolism of xenobiotics by cytochrome P450 - Microcebus murinus (gray mouse lemur)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mmur00980  Metabolism of xenobiotics by cytochrome P450
mmur00980

Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105854864  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
105868328  cytochrome P450 3A4-like [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
105868331  cytochrome P450 3A4 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
105884508  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
105874655  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
105874660  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
105860497  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
105869168  glutathione S-transferase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105869170  LOW QUALITY PROTEIN: glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
105869190  glutathione S-transferase A1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
105869191  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
105869211  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105869212  LOW QUALITY PROTEIN: glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
105862780  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
105862781  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
105862782  glutathione S-transferase theta-3 [KO:K00799] [EC:2.5.1.18]
105862783  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
105877389  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
105863995  GSTM4; glutathione S-transferase Mu 4 isoform X1 [KO:K00799] [EC:2.5.1.18]
105863998  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
105864000  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
109729221  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
105872351  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
105867418  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
105867419  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
105873288  GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]
105870772  HPGDS; hematopoietic prostaglandin D synthase isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
105863794  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
105869127  cytochrome P450 2B6-like isoform X1 [KO:K17709] [EC:1.14.14.-]
105869130  cytochrome P450 2B6-like [KO:K17709] [EC:1.14.14.-]
105869132  cytochrome P450 2B4-like isoform X1 [KO:K17709] [EC:1.14.14.-]
105868193  bile salt sulfotransferase-like isoform X1 [KO:K11822] [EC:2.8.2.14]
105868194  bile salt sulfotransferase-like isoform X1 [KO:K11822] [EC:2.8.2.14]
105869600  SULT2A1; bile salt sulfotransferase [KO:K11822] [EC:2.8.2.14]
105873827  bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]
105854822  cytochrome P450 1A2-like [KO:K07409] [EC:1.14.14.1]
105861495  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
105876750  cytochrome P450 2F5 [KO:K07416] [EC:1.14.14.1]
105869131  cytochrome P450 2S1 isoform X1 [KO:K07420] [EC:1.14.14.1]
105865597  DHDH; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]
105858587  LOW QUALITY PROTEIN: cytochrome P450 2D17-like [KO:K17712] [EC:1.14.14.1]
105858588  cytochrome P450 2D17-like isoform X8 [KO:K17712] [EC:1.14.14.1]
105869645  HSD11B1L; hydroxysteroid 11-beta-dehydrogenase 1-like protein isoform X1 [KO:K15680] [EC:1.1.1.146]
105880569  HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1 [KO:K15680] [EC:1.1.1.146]
105881306  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
105881307  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
105881308  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
105878069  carbonyl reductase [NADPH] 2-like [KO:K00081] [EC:1.1.1.184]
105881309  carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
105883051  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
105883080  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
105883081  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105883083  UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105883084  UDP-glucuronosyltransferase 2B4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105883085  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
105883086  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
105869279  UDP-glucuronosyltransferase 2B7-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105869299  UDP-glucuronosyltransferase 2B4-like isoform X3 [KO:K00699] [EC:2.4.1.17]
105869304  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
105886128  UDP-glucuronosyltransferase 1-1-like isoform X1 [KO:K00699] [EC:2.4.1.17]
105886138  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105886140  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105886142  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
105886143  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105886144  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
109729189  UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]
109729208  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
109730987  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
105864507  UDP-glucuronosyltransferase 2A1-like [KO:K00699] [EC:2.4.1.17]
105864508  UDP-glucuronosyltransferase 2A1 isoform X10 [KO:K00699] [EC:2.4.1.17]
105884019  AKR7A2; aflatoxin B1 aldehyde reductase member 2 [KO:K15303]
105884020  aflatoxin B1 aldehyde reductase member 3 [KO:K15303]
105867427  aldehyde dehydrogenase family 3 member B2-like [KO:K00129] [EC:1.2.1.5]
105867429  ALDH3B1; aldehyde dehydrogenase family 3 member B1 isoform X1 [KO:K00129] [EC:1.2.1.5]
105862011  ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
105856572  ADH7; alcohol dehydrogenase class 4 mu/sigma chain [KO:K13951] [EC:1.1.1.1]
105856576  alcohol dehydrogenase 1C [KO:K13951] [EC:1.1.1.1]
105856584  alcohol dehydrogenase 1C-like [KO:K13951] [EC:1.1.1.1]
105856578  ADH4; alcohol dehydrogenase 4 [KO:K13980] [EC:1.1.1.1]
105856574  ADH5; alcohol dehydrogenase class-3 isoform X1 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
Compound
C00745  Nicotine
C00829  Naphthalene
C02617  1,4-Naphthoquinone
C03012  Naphthalene-1,2-diol
C06205  1,2-Dihydronaphthalene-1,2-diol
C06755  Chloroacetic acid
C06790  Trichloroethene
C06800  Aflatoxin B1
C06899  Chloral hydrate
C07490  Trichloroethanol
C07535  Benzo[a]pyrene
C11036  Bromobenzene
C11088  1,2-Dibromoethane
C11148  TCE epoxide
C11149  Dichloroacetate
C11150  Trichloroacetate
C11278  Aflatoxin B1exo-8,9-epoxide-GSH
C11713  2-Naphthol
C11714  1-Naphthol
C14039  1,1-Dichloroethylene
C14040  1-Nitronaphthalene
C14453  4-Bromophenol
C14556  9-Hydroxybenzo[a]pyrene
C14783  1,2-Naphthoquinone
C14784  1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene
C14785  1,4-Dihydroxynaphthalene
C14786  (1R,2S)-Naphthalene 1,2-oxide
C14787  (1S,2R)-Naphthalene 1,2-oxide
C14788  1-Nitrosonaphthalene
C14789  N-Hydroxy-1-aminonaphthalene
C14790  1-Naphthylamine
C14791  (1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
C14792  (1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
C14793  (1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14796  (1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14797  (1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene
C14798  (1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene
C14799  (1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid
C14800  1-Nitronaphthalene-5,6-oxide
C14801  1-Nitro-5,6-dihydroxy-dihydronaphthalene
C14802  1-Nitronaphthalene-7,8-oxide
C14803  1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
C14804  1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
C14805  1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
C14806  1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
C14839  Bromobenzene-3,4-oxide
C14840  Bromobenzene-2,3-oxide
C14841  2-Bromophenol
C14842  Bromobenzene-2,3-dihydrodiol
C14843  4-Bromocatechol
C14844  Bromobenzene-3,4-dihydrodiol
C14845  4-Bromophenol-2,3-epoxide
C14846  4-Bromo-3,5-cyclohexadiene-1,2-dione
C14847  3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
C14848  2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
C14849  Benzo[a]pyrene-9,10-oxide
C14850  Benzo[a]pyrene-7,8-oxide
C14851  Benzo[a]pyrene-4,5-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C14853  Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide
C14854  9-Hydroxybenzo[a]pyrene-4,5-oxide
C14855  4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
C14856  7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene
C14857  1,1-Dichloroethylene epoxide
C14858  2,2-Dichloroacetaldehyde
C14859  Chloroacetyl chloride
C14860  2,2-Dichloro-1,1-ethanediol
C14861  S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
C14862  2-S-Glutathionyl acetate
C14863  2-(S-Glutathionyl)acetyl glutathione
C14864  S-(2-Chloroacetyl)glutathione
C14865  2-(S-Glutathionyl)acetyl chloride
C14866  Chloral
C14867  Dichloroacetyl chloride
C14868  S-(1,2-Dichlorovinyl)glutathione
C14869  Trichloroethanol glucuronide
C14870  2-Bromoacetaldehyde
C14871  S-(Formylmethyl)glutathione
C14872  Thiodiacetic acid
C14873  Thiodiacetic acid sulfoxide
C14874  Glutathione episulfonium ion
C14875  S-(2-Hydroxyethyl)glutathione
C14876  S-(2-Hydroxyethyl)-N-acetyl-L-cysteine
C14877  S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16756  Aflatoxin M1
C19488  7,12-Dimethylbenz[a]anthracene
C19489  1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene
C19490  trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene
C19559  (1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol
C19561  7-Hydroxymethyl-12-methylbenz[a]anthracene
C19562  7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate
C19563  4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone
C19564  4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone
C19565  4-Hydroxy-1-(3-pyridinyl)-1-butanone
C19566  4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone
C19567  4-Oxo-1-(3-pyridyl)-1-butanone
C19568  N-Nitrosomethanamine
C19569  3-Succinoylpyridine
C19574  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol
C19577  1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol
C19578  5-(3-Pyridyl)-2-hydroxytetrahydrofuran
C19579  gamma-Hydroxy-3-pyridinebutanoate
C19580  alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol
C19581  alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol
C19582  1-(3-Pyridinyl)-1,4-butanediol
C19585  Aflatoxin Q1
C19586  Aflatoxin B1-exo-8,9-epoxide
C19588  Aflatoxin B1 diol
C19589  Aflatoxin B1 dialdehyde
C19590  6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione
C19591  1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal
C19592  alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde
C19594  Aflatoxin-M1-8,9-epoxide
C19595  Aflatoxin B1-endo-8,9-epoxide
C19602  4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone
C19603  4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol
C19604  7,12-Dimethylbenz[a]anthracene 5,6-oxide
C19605  4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide
C19606  NNAL-N-glucuronide
C19607  trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene
Reference
PMID:12487150
  Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
  Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
  Journal
Drug Metab Rev 34:791-820 (2002)
DOI:10.1081/DMR-120015694
Reference
PMID:10725110
  Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
  Title
Role of quinones in toxicology.
  Journal
Chem Res Toxicol 13:135-60 (2000)
DOI:10.1021/tx9902082
Reference
PMID:10570027
  Authors
Halladay JS, Sauer JM, Sipes IG.
  Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
  Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
PMID:10490505
  Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
  Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
  Journal
Chem Res Toxicol 12:831-9 (1999)
DOI:10.1021/tx990023v
Reference
PMID:15319346
  Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
  Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
  Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
PMID:15987776
  Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
  Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
  Journal
Drug Metab Dispos 33:1429-37 (2005)
DOI:10.1124/dmd.105.005074
Reference
PMID:9107551
  Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
  Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
  Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
PMID:4395686
  Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
  Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
  Journal
Proc Natl Acad Sci U S A 68:160-4 (1971)
DOI:10.1073/pnas.68.1.160
Reference
PMID:15298956
  Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
  Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
  Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
  Authors
Omura T, Ishimura Y, Fujii Y (eds).
  Title
[Molecular Biology of P450] (In Japanese)
  Journal
Kodansya (2003)
KO pathway
ko00980   
LinkDB

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