KEGG   PATHWAY: mqu00983
Entry
mqu00983                    Pathway                                
Name
Drug metabolism - other enzymes - Macrosteles quadrilineatus (aster leafhopper)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mqu00983  Drug metabolism - other enzymes
mqu00983

Organism
Macrosteles quadrilineatus (aster leafhopper) [GN:mqu]
Gene
128984802  inosine-5'-monophosphate dehydrogenase 1-like isoform X1 [KO:K00088] [EC:1.1.1.205]
128997884  inosine-5'-monophosphate dehydrogenase 1-like isoform X1 [KO:K00088] [EC:1.1.1.205]
128988882  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
128986768  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128986893  uncharacterized protein LOC128986893 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128986901  uncharacterized protein LOC128986901 isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128996166  xanthine dehydrogenase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128988133  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128988138  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128999016  uncharacterized protein LOC128999016 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129000398  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129000555  uncharacterized protein LOC129000555 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129000574  uncharacterized protein LOC129000574 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
129001378  uncharacterized protein LOC129001378 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
128985193  UDP-glycosyltransferase UGT4-like [KO:K00699] [EC:2.4.1.17]
129003329  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
128986467  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
128996169  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
128996375  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
128996435  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
128996463  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128987324  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
128996762  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
128997117  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
128998961  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
128998981  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
128999378  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128999432  UDP-glycosyltransferase UGT4-like [KO:K00699] [EC:2.4.1.17]
128999654  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
128999655  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
128999814  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
128999816  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
128999964  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128981914  UDP-glycosyltransferase UGT4-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128992157  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128992253  UDP-glycosyltransferase UGT4-like [KO:K00699] [EC:2.4.1.17]
129002100  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
129002589  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
128983963  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
128992853  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
128993758  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
129000282  beta-glucuronidase-like [KO:K01195] [EC:3.2.1.31]
129004483  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
128998674  cytidine deaminase-like [KO:K01489] [EC:3.5.4.5]
128987814  thymidine phosphorylase-like [KO:K00758] [EC:2.4.2.4]
128988111  thymidine phosphorylase-like isoform X1 [KO:K00758] [EC:2.4.2.4]
128999015  dihydropyrimidine dehydrogenase [NADP(+)] [KO:K00207] [EC:1.3.1.2]
128997813  dihydropyrimidinase-like [KO:K01464] [EC:3.5.2.2]
128998030  dihydropyrimidinase-like isoform X1 [KO:K01464] [EC:3.5.2.2]
128994491  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
128994854  beta-ureidopropionase-like [KO:K01431] [EC:3.5.1.6]
128998155  uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
129004515  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
129002255  uridine-cytidine kinase-like 1 [KO:K00876] [EC:2.7.1.48]
128993233  uridine-cytidine kinase isoform X1 [KO:K00876] [EC:2.7.1.48]
128996654  deoxynucleoside kinase-like [KO:K00857] [EC:2.7.1.21]
128997144  deoxynucleoside kinase-like [KO:K00857] [EC:2.7.1.21]
128990993  deoxynucleoside kinase-like isoform X1 [KO:K00857] [EC:2.7.1.21]
128983268  deoxynucleoside kinase-like isoform X1 [KO:K00857] [EC:2.7.1.21]
128999781  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
128999886  uridine 5'-monophosphate synthase-like [KO:K13421] [EC:2.4.2.10 4.1.1.23]
128988765  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
128989716  UMP-CMP kinase-like [KO:K13800] [EC:2.7.4.14]
128985685  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
129003837  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
129004028  ribonucleoside-diphosphate reductase subunit M2 B-like [KO:K10808] [EC:1.17.4.1]
128994425  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
128989796  nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
128989867  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
128990353  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
129005800  uncharacterized protein LOC129005800 [KO:K01520] [EC:3.6.1.23]
128984328  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
129003297  nucleolar protein 58-like [KO:K01520] [EC:3.6.1.23]
128995689  uncharacterized protein LOC128995689 [KO:K01520] [EC:3.6.1.23]
129000438  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
129000765  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
128982631  uncharacterized protein LOC128982631 [KO:K01520] [EC:3.6.1.23]
128982727  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
129005250  uncharacterized protein LOC129005250 [KO:K01520] [EC:3.6.1.23]
128984258  uncharacterized protein LOC128984258 [KO:K01520] [EC:3.6.1.23]
129002772  microsomal glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
128994364  pyrimidodiazepine synthase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
129003460  uncharacterized protein LOC129003460 [KO:K00799] [EC:2.5.1.18]
128986179  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
128995269  pyrimidodiazepine synthase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128986427  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128987371  glutathione S-transferase D7-like isoform X1 [KO:K00799] [EC:2.5.1.18]
128988775  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
128998877  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
128989890  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
128999333  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
128999352  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
128999671  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
128990177  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
129001873  glutathione S-transferase D7-like [KO:K00799] [EC:2.5.1.18]
129002457  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
129005387  uncharacterized protein LOC129005387 [KO:K00799] [EC:2.5.1.18]
129005388  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
128983367  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
LinkDB

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