KEGG   PATHWAY: mthb04390
Entry
mthb04390                   Pathway                                
Name
Hippo signaling pathway - Macaca thibetana thibetana (Pere David's macaque)
Description
Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
mthb04390  Hippo signaling pathway
mthb04390

Other DBs
GO: 0035329
Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126937202  protein crumbs homolog 2 [KO:K16681]
126939647  protein crumbs homolog 1 isoform X1 [KO:K16681]
126962979  partitioning defective 3 homolog isoform X1 [KO:K04237]
126944023  partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
126964388  partitioning defective 6 homolog beta [KO:K06093]
126941471  LOW QUALITY PROTEIN: partitioning defective 6 homolog gamma-like [KO:K06093]
126951757  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
126947535  protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
126933063  inaD-like protein isoform X1 [KO:K06092]
126958648  protein PALS1 isoform X1 [KO:K06091]
126946459  angiomotin isoform X1 [KO:K16819]
126936003  transcriptional coactivator YAP1 isoform X1 [KO:K16687]
126948234  WW domain-containing transcription regulator protein 1 [KO:K16820]
126944055  cadherin-1 [KO:K05689]
126958272  LIM domain-containing protein ajuba [KO:K16682]
126941912  Wilms tumor protein 1-interacting protein [KO:K16682]
126948560  LIM domain-containing protein 1 isoform X1 [KO:K16682]
126963967  merlin isoform X1 [KO:K16684]
126957131  protein KIBRA isoform X1 [KO:K16685]
126952449  FERM domain-containing protein 1 isoform X1 [KO:K16821]
126958507  FERM domain-containing protein 6 isoform X1 [KO:K16822]
126958522  protein salvador homolog 1 [KO:K16686]
126961142  serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
126954636  ras association domain-containing protein 6 [KO:K09854]
126948713  ras association domain-containing protein 1 isoform X1 [KO:K09850]
126961792  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
126955999  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
126943032  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
126935784  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
126961827  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
126955498  protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
126963299  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
126956781  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
126940687  LOW QUALITY PROTEIN: serine/threonine-protein kinase LATS2 [KO:K08791] [EC:2.7.11.1]
126952489  serine/threonine-protein kinase LATS1 isoform X1 [KO:K08791] [EC:2.7.11.1]
126955148  MOB kinase activator 1B isoform X1 [KO:K06685]
126956010  MOB kinase activator 1A-like [KO:K06685]
126934072  MOB kinase activator 1A isoform X1 [KO:K06685]
126931492  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
126933834  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
126935389  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
126937260  apoptosis-stimulating of p53 protein 2 isoform X1 [KO:K16823]
126938781  lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
126939167  LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
126960933  protein scribble homolog isoform X1 [KO:K16175]
126947952  disks large homolog 1 isoform X1 [KO:K12076]
126934894  disks large homolog 2 isoform X1 [KO:K12075]
126946175  disks large homolog 3 isoform X1 [KO:K21098]
126939676  disks large homolog 4 isoform X1 [KO:K11828]
126962405  disks large homolog 5 isoform X1 [KO:K24050]
126939934  casein kinase I isoform X1 [KO:K08959] [EC:2.7.11.1]
126963728  casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
126956334  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
126963066  F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
126962888  tumor protein p73 isoform X1 [KO:K10148]
126943534  bcl-2-binding component 3 [KO:K10132]
126943571  transcriptional enhancer factor TEF-4 isoform X1 [KO:K09448]
126931740  transcriptional enhancer factor TEF-3 [KO:K09448]
126952781  transcriptional enhancer factor TEF-5 isoform X1 [KO:K09448]
126953367  transcriptional enhancer factor TEF-3-like [KO:K09448]
126935652  transcriptional enhancer factor TEF-1 isoform X1 [KO:K09448]
126952047  CCN family member 2 [KO:K06827]
126932004  zinc finger protein GLI2 [KO:K16798]
126954907  amphiregulin [KO:K09782]
126963345  baculoviral IAP repeat-containing protein 5-like [KO:K08731]
126939275  baculoviral IAP repeat-containing protein 5 [KO:K08731]
126954640  alpha-fetoprotein [KO:K16144]
126950616  integrin beta-2 isoform X1 [KO:K06464]
126957258  LOW QUALITY PROTEIN: fibroblast growth factor 1 [KO:K18496]
126941768  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
126948495  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
126959539  transforming growth factor beta-3 proprotein [KO:K13377]
126938052  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
126946646  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
126941003  mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
126941494  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
126957972  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
126941313  mothers against decapentaplegic homolog 4 [KO:K04501]
126950371  plasminogen activator inhibitor 1 [KO:K03982]
126964143  bone morphogenetic protein 2 [KO:K21283]
126959339  bone morphogenetic protein 4 isoform X1 [KO:K04662]
126953298  bone morphogenetic protein 5 [KO:K04663]
126952658  bone morphogenetic protein 6 [KO:K16620]
126929153  bone morphogenetic protein 7 [KO:K16621]
126959926  bone morphogenetic protein 8B [KO:K16622]
126959932  bone morphogenetic protein 8A [KO:K16622]
126964223  growth/differentiation factor 5 [KO:K04664]
126960825  growth/differentiation factor 6 [KO:K20012]
126934126  growth/differentiation factor 7 [KO:K20013]
126942588  muellerian-inhibiting factor [KO:K04665]
126962610  bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
126955376  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
126932176  bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
126955322  mothers against decapentaplegic homolog 1 [KO:K04676]
126964315  DNA-binding protein inhibitor ID-1 [KO:K04680]
126933503  DNA-binding protein inhibitor ID-2 [KO:K17693]
126930178  proto-oncogene Wnt-1 [KO:K03209]
126930501  protein Wnt-2b [KO:K00182]
126951195  protein Wnt-2 [KO:K00182]
126936033  protein Wnt-3a [KO:K00312]
126938314  proto-oncogene Wnt-3 [KO:K00312]
126956796  protein Wnt-4 [KO:K00408]
126930247  protein Wnt-5b [KO:K00444]
126947624  protein Wnt-5a isoform X1 [KO:K00444]
126933008  protein Wnt-6 isoform X1 [KO:K00445]
126949140  protein Wnt-7a [KO:K00572]
126963624  protein Wnt-7b isoform X1 [KO:K00572]
126963076  protein Wnt-8b [KO:K00714]
126957556  protein Wnt-8a [KO:K00714]
126938932  protein Wnt-9b isoform X1 [KO:K01064]
126935947  protein Wnt-9a isoform X1 [KO:K01064]
126930177  protein Wnt-10b [KO:K01357]
126933003  protein Wnt-10a [KO:K01357]
126935098  protein Wnt-11 isoform X1 [KO:K01384]
126950813  protein Wnt-16 [KO:K01558]
126932182  frizzled-7 [KO:K02432]
126949919  frizzled-1 [KO:K02432]
126938678  frizzled-2 [KO:K02235]
126961767  frizzled-3 isoform X1 [KO:K02329]
126934903  frizzled-4 isoform X1 [KO:K02354]
126962319  LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
126933089  frizzled-5 [KO:K02375]
126960879  frizzled-6 isoform X1 [KO:K02376]
126930546  frizzled-10 [KO:K02842]
126950358  frizzled-9 [KO:K02842]
126939681  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
126951679  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
126948407  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
126954352  14-3-3 protein theta [KO:K16197]
126955364  14-3-3 protein theta-like [KO:K16197]
126963854  14-3-3 protein beta/alpha isoform X1 [KO:K16197]
126933791  14-3-3 protein theta isoform X1 [KO:K16197]
126960893  14-3-3 protein zeta/delta [KO:K16197]
126938876  14-3-3 protein epsilon isoform X1 [KO:K06630]
126950246  14-3-3 protein epsilon-like [KO:K06630]
126963946  14-3-3 protein eta isoform X1 [KO:K16198]
126950401  14-3-3 protein gamma [KO:K16198]
126949239  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126948505  catenin beta-1 isoform X1 [KO:K02105]
126942456  LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
126956213  adenomatous polyposis coli protein isoform X1 [KO:K02085]
126944825  axin-1 isoform X1 [KO:K02157]
126938336  axin-2 isoform X1 [KO:K04385]
126944910  protein naked cuticle homolog 1 [KO:K03213]
126957412  protein naked cuticle homolog 2 isoform X1 [KO:K03213]
126955989  transcription factor 7 isoform X1 [KO:K02620]
126933391  transcription factor 7-like 1 isoform X1 [KO:K04490]
126962827  transcription factor 7-like 2 isoform X1 [KO:K04491]
126954934  lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
126960612  myc proto-oncogene protein [KO:K04377]
126935963  G1/S-specific cyclin-D1 [KO:K04503]
126931745  G1/S-specific cyclin-D2 [KO:K10151]
126953804  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
126948388  transcription factor SOX-2 [KO:K16796]
126960589  zinc finger protein SNAI2 [KO:K05706]
126936001  baculoviral IAP repeat-containing protein 2 [KO:K16060]
126936002  baculoviral IAP repeat-containing protein 3 [KO:K16060]
126932601  actin, cytoplasmic 2 [KO:K05692]
126939111  actin, cytoplasmic 2 [KO:K05692]
126950494  actin, cytoplasmic 1 isoform X1 [KO:K05692]
126958358  LOW QUALITY PROTEIN: actin-like [KO:K05692]
126963368  catenin alpha-3 isoform X1 [KO:K05691]
126957275  catenin alpha-1 isoform X1 [KO:K05691]
126933368  catenin alpha-2 isoform X1 [KO:K05691]
Reference
PMID:22750148
  Authors
Schroeder MC, Halder G
  Title
Regulation of the Hippo pathway by cell architecture and mechanical signals.
  Journal
Semin Cell Dev Biol 23:803-11 (2012)
DOI:10.1016/j.semcdb.2012.06.001
Reference
PMID:21808241
  Authors
Zhao B, Tumaneng K, Guan KL
  Title
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
  Journal
Nat Cell Biol 13:877-83 (2011)
DOI:10.1038/ncb2303
Reference
PMID:21874053
  Authors
Mauviel A, Nallet-Staub F, Varelas X
  Title
Integrating developmental signals: a Hippo in the (path)way.
  Journal
Oncogene 31:1743-56 (2012)
DOI:10.1038/onc.2011.363
Reference
PMID:21084559
  Authors
Zhao B, Li L, Guan KL
  Title
Hippo signaling at a glance.
  Journal
J Cell Sci 123:4001-6 (2010)
DOI:10.1242/jcs.069070
Reference
PMID:20439427
  Authors
Zhao B, Li L, Lei Q, Guan KL
  Title
The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
  Journal
Genes Dev 24:862-74 (2010)
DOI:10.1101/gad.1909210
Reference
PMID:23034192
  Authors
Tremblay AM, Camargo FD
  Title
Hippo signaling in mammalian stem cells.
  Journal
Semin Cell Dev Biol 23:818-26 (2012)
DOI:10.1016/j.semcdb.2012.08.001
Reference
PMID:21138973
  Authors
Halder G, Johnson RL
  Title
Hippo signaling: growth control and beyond.
  Journal
Development 138:9-22 (2011)
DOI:10.1242/dev.045500
Reference
PMID:22658639
  Authors
Ramos A, Camargo FD
  Title
The Hippo signaling pathway and stem cell biology.
  Journal
Trends Cell Biol 22:339-46 (2012)
DOI:10.1016/j.tcb.2012.04.006
Reference
PMID:20951342
  Authors
Pan D
  Title
The hippo signaling pathway in development and cancer.
  Journal
Dev Cell 19:491-505 (2010)
DOI:10.1016/j.devcel.2010.09.011
Reference
PMID:21324984
  Authors
Bao Y, Hata Y, Ikeda M, Withanage K
  Title
Mammalian Hippo pathway: from development to cancer and beyond.
  Journal
J Biochem 149:361-79 (2011)
DOI:10.1093/jb/mvr021
Reference
PMID:18955139
  Authors
Zhao B, Lei QY, Guan KL
  Title
The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
  Journal
Curr Opin Cell Biol 20:638-46 (2008)
DOI:10.1016/j.ceb.2008.10.001
Reference
PMID:20945341
  Authors
Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
  Title
The Hippo pathway in biological control and cancer development.
  Journal
J Cell Physiol 226:928-39 (2011)
DOI:10.1002/jcp.22435
Reference
PMID:18328423
  Authors
Zeng Q, Hong W
  Title
The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals.
  Journal
Cancer Cell 13:188-92 (2008)
DOI:10.1016/j.ccr.2008.02.011
Reference
PMID:19846288
  Authors
Badouel C, Garg A, McNeill H
  Title
Herding Hippos: regulating growth in flies and man.
  Journal
Curr Opin Cell Biol 21:837-43 (2009)
DOI:10.1016/j.ceb.2009.09.010
Reference
PMID:17975546
  Authors
Buttitta LA, Edgar BA
  Title
How size is controlled: from Hippos to Yorkies.
  Journal
Nat Cell Biol 9:1225-7 (2007)
DOI:10.1038/ncb1107-1225
Reference
PMID:22683405
  Authors
Liu AM, Wong KF, Jiang X, Qiao Y, Luk JM
  Title
Regulators of mammalian Hippo pathway in cancer.
  Journal
Biochim Biophys Acta 1826:357-64 (2012)
DOI:10.1016/j.bbcan.2012.05.006
Reference
PMID:22830020
  Authors
Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
  Title
Hippo and rassf1a Pathways: A Growing Affair.
  Journal
Mol Biol Int 2012:307628 (2012)
DOI:10.1155/2012/307628
Reference
PMID:22895435
  Authors
Halder G, Dupont S, Piccolo S
  Title
Transduction of mechanical and cytoskeletal cues by YAP and TAZ.
  Journal
Nat Rev Mol Cell Biol 13:591-600 (2012)
DOI:10.1038/nrm3416
Reference
PMID:22153608
  Authors
Varelas X, Wrana JL
  Title
Coordinating developmental signaling: novel roles for the Hippo pathway.
  Journal
Trends Cell Biol 22:88-96 (2012)
DOI:10.1016/j.tcb.2011.10.002
Reference
PMID:21376238
  Authors
Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez JR, Zhou D, Kreger BT, Vasioukhin V, Avruch J, Brummelkamp TR, Camargo FD
  Title
Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
  Journal
Cell 144:782-95 (2011)
DOI:10.1016/j.cell.2011.02.031
Related
pathway
mthb04120  Ubiquitin mediated proteolysis
mthb04310  Wnt signaling pathway
mthb04350  TGF-beta signaling pathway
mthb04520  Adherens junction
mthb04530  Tight junction
KO pathway
ko04390   
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