KEGG PATHWAY: nph00730

PATHWAY: nph00730

Entry

nph00730                    Pathway

Name

Thiamine metabolism - Natronomonas pharaonis

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

nph00730

Thiamine metabolism

Module

nph_M00896

Thiamine biosynthesis, archaea, AIR (+ NAD+) => TMP/TPP [PATH:nph00730]

nph_M00899

Thiamine salvage pathway, HMP/HET => TMP [PATH:nph00730]

Other DBs

GO:

0006772

Organism

Natronomonas pharaonis [GN:nph]

Gene

NP_2210A

thiC; phosphomethylpyrimidine synthase [KO:K03147] [EC:4.1.99.17]

NP_0546A

thiDN; phosphomethylpyrimidine kinase / phosphomethylpyrimidine phosphate kinase / thiamine-phosphate synthase [KO:K21219] [EC:2.7.1.49 2.7.4.7 2.5.1.3]

NP_3782A

thiI; ThiI-type thiouridine biosynthesis protein [KO:K03151] [EC:2.8.1.4]

NP_5174A

thi4; thiamine thiazole synthase [KO:K22699] [EC:2.4.2.59]

NP_4052A

thiM; hydroxyethylthiazole kinase [KO:K00878] [EC:2.7.1.50]

NP_4054A

thiE; thiamine-phosphate synthase [KO:K00788] [EC:2.5.1.3]

NP_2280A

thiL; thiamine-monophosphate kinase [KO:K00946] [EC:2.7.4.16]

NP_4910A

adk1; adenylate kinase [KO:K00939] [EC:2.7.4.3]

NP_4082A

tenA2; aminopyrimidine aminohydrolase [KO:K03707] [EC:3.5.99.2]

NP_4080A

tenA1; aminopyrimidine aminohydrolase [KO:K03707] [EC:3.5.99.2]

Compound

C00003

NAD+

C00018

Pyridoxal phosphate

C00022

Pyruvate

C00037

Glycine

C00068

Thiamin diphosphate

C00082

L-Tyrosine

C00097

L-Cysteine

C00118

D-Glyceraldehyde 3-phosphate

C00378

Thiamine

C01081

Thiamin monophosphate

C01279

4-Amino-5-hydroxymethyl-2-methylpyrimidine

C02892

Thiamine acetic acid

C03028

Thiamin triphosphate

C03373

Aminoimidazole ribotide

C04294

5-(2-Hydroxyethyl)-4-methylthiazole

C04327

4-Methyl-5-(2-phosphooxyethyl)thiazole

C04556

4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine

C04752

4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate

C05856

Thiamine aldehyde

C11437

1-Deoxy-D-xylulose 5-phosphate

C15809

Iminoglycine

C15810

Sulfur-carrier protein

C15811

[Enzyme]-cysteine

C15812

[Enzyme]-S-sulfanylcysteine

C15813

Adenylyl-[sulfur-carrier protein]

C15814

Thiocarboxy-[sulfur-carrier protein]

C19872

N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine

C20246

2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate

C20247

2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate

C20267

4-Amino-5-aminomethyl-2-methylpyrimidine

C20784

ADP-5-ethyl-4-methylthiazole-2-carboxylate

Reference

PMID:15614489

Authors

Kawasaki Y, Onozuka M, Mizote T, Nosaka K.

Title

Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.

Journal

Curr Genet 47:156-62 (2005)
DOI:10.1007/s00294-004-0557-x

Reference

PMID:14567704

Authors

Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.

Title

Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).

Journal

Biochemistry 42:12430-8 (2003)
DOI:10.1021/bi034902z

Reference

PMID:22616866

Authors

Begley TP, Ealick SE, McLafferty FW

Title

Thiamin biosynthesis: still yielding fascinating biological chemistry.

Journal

Biochem Soc Trans 40:555-60 (2012)
DOI:10.1042/BST20120084

Reference

PMID:12777485

Authors

Wightman R, Meacock PA

Title

The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.

Journal

Microbiology 149:1447-60 (2003)
DOI:10.1099/mic.0.26194-0

Reference

PMID:22031445

Authors

Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP

Title

Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.

Journal

Nature 478:542-6 (2011)
DOI:10.1038/nature10503

Reference

PMID:19348578