KEGG   PATHWAY: nta00480
Entry
nta00480                    Pathway                                
Name
Glutathione metabolism - Nicotiana tabacum (common tobacco)
Class
Metabolism; Metabolism of other amino acids
Pathway map
nta00480  Glutathione metabolism
nta00480

Module
nta_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:nta00480]
Other DBs
GO: 0006749
Organism
Nicotiana tabacum (common tobacco) [GN:nta]
Gene
107794792  gamma-glutamyltranspeptidase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107789318  gamma-glutamyltranspeptidase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107798576  gamma-glutamyltranspeptidase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107781774  putative inactive gamma-glutamyltranspeptidase 4 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107784134  gamma-glutamyltranspeptidase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
107780043  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K22596] [EC:4.3.2.9]
107779408  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K22596] [EC:4.3.2.9]
107779373  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K22596] [EC:4.3.2.9]
107789157  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K22596] [EC:4.3.2.9]
107813044  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K22596] [EC:4.3.2.9]
107789186  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K22596] [EC:4.3.2.9]
107781908  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
107803589  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
107784172  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
107799938  GCS; glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
107832748  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
107821526  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
107768570  lap2; leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
107801578  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
107814831  puromycin-sensitive aminopeptidase-like [KO:K01256] [EC:3.4.11.2]
107782212  puromycin-sensitive aminopeptidase-like [KO:K01256] [EC:3.4.11.2]
107768630  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107765621  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107819594  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
107800921  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107800922  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107824401  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
107825222  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107816088  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107761963  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
107782952  C-7; probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107779134  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107779135  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
107784129  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
107760143  parAs; probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
107763456  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
107762421  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
107789895  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107821321  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
107807650  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107824839  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107777632  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
107823949  PAR-C; probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
107782951  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107765700  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107800866  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107802704  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107793760  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
107764067  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107769085  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107769090  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107769091  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107769092  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107771506  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
107771507  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
107825375  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107789271  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107783709  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107808945  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107815009  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107819441  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107806905  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
107776507  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107794811  GST1; glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107831268  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107831270  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107820298  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107827765  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
107790974  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
107770509  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
107797901  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
107798067  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107763767  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
107831351  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
107831831  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
107831833  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107831834  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107759987  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
107760904  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
107823913  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107778458  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
107779706  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107779707  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107779708  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107779711  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107779712  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107779739  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
107779750  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
107782987  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
107796058  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
107760440  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107775362  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
107775363  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
107775364  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
107821964  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107810794  ERT1; probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107825548  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107825557  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107772524  PARA; probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
107779283  APIC; glutathione S-transferase APIC [KO:K00799] [EC:2.5.1.18]
107795177  parB; glutathione S-transferase PARB [KO:K00799] [EC:2.5.1.18]
107822391  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
107825577  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107802218  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107814292  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107816353  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107769388  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107769389  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107769391  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
107777621  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
107772392  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107807101  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107813571  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107763870  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
107764934  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
107823951  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107776506  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
107761212  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
107818133  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
107819842  DHAR; glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107773610  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107777254  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107767974  GR; glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
107817696  gor; glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
107777121  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
107777100  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
107768947  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
107801694  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
107816938  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial-like [KO:K00031] [EC:1.1.1.42]
107812507  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
107814140  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
107809524  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
107815853  IDH; isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
107791333  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107799009  6-phosphogluconate dehydrogenase, decarboxylating 3-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107789656  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107777046  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107779182  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
107758909  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107794892  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107831534  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107805957  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107822069  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107786177  G6PDHP2; glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107795692  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107828938  G6PD; glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
107809063  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
107811982  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
107767209  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107774241  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
107820597  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
107795121  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107779288  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
107796059  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
107784785  Nt-SubC08; probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107798829  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107763885  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
107813066  glutathione peroxidase homolog BsaA-like [KO:K00432] [EC:1.11.1.9]
107810138  1-Cys peroxiredoxin-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
107823604  1-Cys peroxiredoxin-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
107789470  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107815922  Nt-odc; ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107771395  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
107801491  ODC; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
107780228  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
107770315  spermine synthase [KO:K00797] [EC:2.5.1.16]
107828197  spds; spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
107765582  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
107763093  spermidine synthase [KO:K00797] [EC:2.5.1.16]
107764611  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
107791412  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
107759348  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
107774730  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107782353  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
107782355  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
107787273  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
107776943  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107765289  APX; L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
107819788  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
107763284  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
107809385  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
107779974  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
107783195  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
107783197  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
107792162  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
107759703  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107775122  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
107807190  RNR1b; ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
107770366  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
107829206  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107803584  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
107807196  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
107781035  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
PMID:12675513
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
PMID:18482986
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
PMID:14583094
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
PMID:11157967
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
PMID:15610825
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
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Related
pathway
nta00220  Arginine biosynthesis
nta00250  Alanine, aspartate and glutamate metabolism
nta00270  Cysteine and methionine metabolism
nta00430  Taurine and hypotaurine metabolism
nta00460  Cyanoamino acid metabolism
KO pathway
ko00480   
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