KEGG   PATHWAY: ocr00260
Entry
ocr00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Ochrobactrum sp. MT180101
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ocr00260  Glycine, serine and threonine metabolism
ocr00260

Module
ocr_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ocr00260]
ocr_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ocr00260]
ocr_M00555  Betaine biosynthesis, choline => betaine [PATH:ocr00260]
ocr_M00621  Glycine cleavage system [PATH:ocr00260]
ocr_M00919  Ectoine degradation, ectoine => aspartate [PATH:ocr00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Ochrobactrum sp. MT180101 [GN:ocr]
Gene
HGK82_10910  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HGK82_18940  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HGK82_06330  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HGK82_02225  homoserine kinase [KO:K02204] [EC:2.7.1.39]
HGK82_02265  threonine synthase [KO:K01733] [EC:4.2.3.1]
HGK82_14570  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
HGK82_03545  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HGK82_12445  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
HGK82_15720  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
HGK82_01585  glycerate kinase [KO:K11529] [EC:2.7.1.165]
HGK82_09395  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
HGK82_18645  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HGK82_09965  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HGK82_09970  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
HGK82_07385  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
HGK82_01335  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
HGK82_24620  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
HGK82_21770  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HGK82_21780  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HGK82_20250  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HGK82_05595  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HGK82_11390  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HGK82_21775  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HGK82_02065  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HGK82_02555  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
HGK82_02550  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
HGK82_07755  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
HGK82_07760  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
HGK82_00565  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
HGK82_00555  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
HGK82_00570  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
HGK82_00560  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
HGK82_14995  PLP-dependent transferase [KO:K01758] [EC:4.4.1.1]
HGK82_05830  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HGK82_19835  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
HGK82_05220  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
HGK82_02030  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
HGK82_11925  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HGK82_11935  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HGK82_15585  ectoine synthase [KO:K06720] [EC:4.2.1.108]
HGK82_19825  doeA; ectoine hydrolase DoeA [KO:K15783] [EC:3.5.4.44]
HGK82_19820  doeB; N-alpha-acetyl diaminobutyric acid deacetylase DoeB [KO:K15784] [EC:3.5.1.125]
HGK82_19850  aspartate aminotransferase family protein [KO:K15785] [EC:2.6.1.76]
HGK82_19845  NAD-dependent succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ocr00010  Glycolysis / Gluconeogenesis
ocr00020  Citrate cycle (TCA cycle)
ocr00230  Purine metabolism
ocr00250  Alanine, aspartate and glutamate metabolism
ocr00270  Cysteine and methionine metabolism
ocr00290  Valine, leucine and isoleucine biosynthesis
ocr00300  Lysine biosynthesis
ocr00330  Arginine and proline metabolism
ocr00460  Cyanoamino acid metabolism
ocr00470  D-Amino acid metabolism
ocr00564  Glycerophospholipid metabolism
ocr00620  Pyruvate metabolism
ocr00630  Glyoxylate and dicarboxylate metabolism
ocr00640  Propanoate metabolism
ocr00680  Methane metabolism
ocr00860  Porphyrin metabolism
ocr00920  Sulfur metabolism
KO pathway
ko00260   
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