KEGG PATHWAY: oga00980

KEGG

PATHWAY: oga00980

Entry

oga00980                    Pathway

Name

Metabolism of xenobiotics by cytochrome P450 - Otolemur garnettii (small-eared galago)

Class

Metabolism; Xenobiotics biodegradation and metabolism

Pathway map

Metabolism of xenobiotics by cytochrome P450

Organism

Otolemur garnettii (small-eared galago) [GN:oga]

Gene

cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]

cytochrome P450 3A4-like [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]

cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]

GSTT2B; glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase theta-4 isoform X2 [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]

GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]

MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase A3 isoform X7 [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase A3-like isoform X1 [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase alpha-4 [KO:K00799] [EC:2.5.1.18]

MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]

GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]

MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]

GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]

glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]

glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]

GSTK1; glutathione S-transferase kappa 1 [KO:K13299] [EC:2.5.1.18]

HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]

EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

LOW QUALITY PROTEIN: bile salt sulfotransferase [KO:K11822] [EC:2.8.2.14]

bile salt sulfotransferase-like [KO:K11822] [EC:2.8.2.14]

cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]

cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]

LOW QUALITY PROTEIN: cytochrome P450 2F5 [KO:K07416] [EC:1.14.14.1]

cytochrome P450 2S1 [KO:K07420] [EC:1.14.14.1]

DHDH; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]

cytochrome P450 2D6-like isoform X1 [KO:K17712] [EC:1.14.14.1]

LOW QUALITY PROTEIN: cytochrome P450 2D17-like [KO:K17712] [EC:1.14.14.1]

HSD11B1; corticosteroid 11-beta-dehydrogenase isozyme 1 [KO:K15680] [EC:1.1.1.146]

HSD11B1L; LOW QUALITY PROTEIN: hydroxysteroid 11-beta-dehydrogenase 1-like protein [KO:K15680] [EC:1.1.1.146]

carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

CBR3; carbonyl reductase [NADPH] 3 isoform X1 [KO:K00084] [EC:1.1.1.184]

UDP-glucuronosyltransferase 2A1 isoform X2 [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 2B31-like isoform X2 [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]

LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-10-like [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 2A3-like [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 2B31-like isoform X1 [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 2B4 [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 2B17-like [KO:K00699] [EC:2.4.1.17]

UGT1A1; UDP-glucuronosyltransferase 1-1 [KO:K00699] [EC:2.4.1.17]

UGT1A6; UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]

UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]

AKR7A3; aflatoxin B1 aldehyde reductase member 3 [KO:K15303]

AKR7A2; aflatoxin B1 aldehyde reductase member 2 isoform X1 [KO:K15303]

ALDH3B1; aldehyde dehydrogenase family 3 member B1 [KO:K00129] [EC:1.2.1.5]

aldehyde dehydrogenase family 3 member B2-like isoform X2 [KO:K00129] [EC:1.2.1.5]

ALDH3A1; aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]

ADH7; alcohol dehydrogenase class 4 mu/sigma chain [KO:K13951] [EC:1.1.1.1]

alcohol dehydrogenase 1C isoform X1 [KO:K13951] [EC:1.1.1.1]

alcohol dehydrogenase 1C isoform X2 [KO:K13951] [EC:1.1.1.1]

ADH4; alcohol dehydrogenase 4 [KO:K13980] [EC:1.1.1.1]

ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]

Compound

Nicotine

Naphthalene

1,4-Naphthoquinone

Naphthalene-1,2-diol

1,2-Dihydronaphthalene-1,2-diol

Chloroacetic acid

Trichloroethene

Aflatoxin B1

Chloral hydrate

Trichloroethanol

Benzo[a]pyrene

Bromobenzene

1,2-Dibromoethane

TCE epoxide

Dichloroacetate

Trichloroacetate

Aflatoxin B1exo-8,9-epoxide-GSH

2-Naphthol

1-Naphthol

1,1-Dichloroethylene

1-Nitronaphthalene

4-Bromophenol

9-Hydroxybenzo[a]pyrene

1,2-Naphthoquinone

1,2-Dihydroxy-3,4-epoxy-1,2,3,4-tetrahydronaphthalene

1,4-Dihydroxynaphthalene

(1R,2S)-Naphthalene 1,2-oxide

(1S,2R)-Naphthalene 1,2-oxide

1-Nitrosonaphthalene

N-Hydroxy-1-aminonaphthalene

1-Naphthylamine

(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene

(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene

(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene

(1R)-Hydroxy-(2R)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene

(1R)-N-Acetyl-L-cysteinyl-(2R)-hydroxy-1,2-dihydronaphthalene

(1S)-Hydroxy-(2S)-N-acetyl-L-cysteinyl-1,2-dihydronaphthalene

(1R,2R)-3-[(1,2-Dihydro-2-hydroxy-1-naphthalenyl)thio]-2-oxopropanoic acid

1-Nitronaphthalene-5,6-oxide

1-Nitro-5,6-dihydroxy-dihydronaphthalene

1-Nitronaphthalene-7,8-oxide

1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene

1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene

1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene

1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene

Bromobenzene-3,4-oxide

Bromobenzene-2,3-oxide

2-Bromophenol

Bromobenzene-2,3-dihydrodiol

4-Bromocatechol

Bromobenzene-3,4-dihydrodiol

4-Bromophenol-2,3-epoxide

4-Bromo-3,5-cyclohexadiene-1,2-dione

3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene

2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene

Benzo[a]pyrene-9,10-oxide

Benzo[a]pyrene-7,8-oxide

Benzo[a]pyrene-4,5-oxide

Benzo[a]pyrene-7,8-dihydrodiol

Benzo[a]pyrene-7,8-dihydrodiol-9,10-oxide

9-Hydroxybenzo[a]pyrene-4,5-oxide

4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene

7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene

1,1-Dichloroethylene epoxide

2,2-Dichloroacetaldehyde

Chloroacetyl chloride

2,2-Dichloro-1,1-ethanediol

S-(2,2-Dichloro-1-hydroxy)ethyl glutathione

2-S-Glutathionyl acetate

2-(S-Glutathionyl)acetyl glutathione

S-(2-Chloroacetyl)glutathione

2-(S-Glutathionyl)acetyl chloride

Chloral

Dichloroacetyl chloride

S-(1,2-Dichlorovinyl)glutathione

Trichloroethanol glucuronide

2-Bromoacetaldehyde

S-(Formylmethyl)glutathione

Thiodiacetic acid

Thiodiacetic acid sulfoxide

Glutathione episulfonium ion

S-(2-Hydroxyethyl)glutathione

S-(2-Hydroxyethyl)-N-acetyl-L-cysteine

S-[2-(N7-Guanyl)ethyl]-N-acetyl-L-cysteine

4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone

Aflatoxin M1

7,12-Dimethylbenz[a]anthracene

1a,11b-Dihydro-4,9-dimethylbenz[a]anthra[3,4-b]oxirene

trans-3,4-Dihydro-3,4-dihydroxy-7,12-dimethylbenz[a]anthracene

(1aalpha,2beta,3alpha,11calpha)-1a,2,3,11c-Tetrahydro-6,11-dimethylbenzo[6,7]phenanthro[3,4-b]oxirene-2,3-diol

7-Hydroxymethyl-12-methylbenz[a]anthracene

7-Hydroxymethyl-12-methylbenz[a]anthracene sulfate

4-[(Hydroxymethyl)nitrosoamino]-1-(3-pyridinyl)-1-butanone

4-(Nitrosoamino)-1-(3-pyridinyl)-1-butanone

4-Hydroxy-1-(3-pyridinyl)-1-butanone

4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone

4-Oxo-1-(3-pyridyl)-1-butanone

N-Nitrosomethanamine

3-Succinoylpyridine

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol

1-(Methylnitrosoamino)-4-(3-pyridinyl)-1,4-butanediol

5-(3-Pyridyl)-2-hydroxytetrahydrofuran

gamma-Hydroxy-3-pyridinebutanoate

alpha-[3-[(Hydroxymethyl)nitrosoamino]propyl]-3-pyridinemethanol

alpha-[3-(Nitrosoamino)propyl]-3-pyridinemethanol

1-(3-Pyridinyl)-1,4-butanediol

Aflatoxin Q1

Aflatoxin B1-exo-8,9-epoxide

Aflatoxin B1 diol

Aflatoxin B1 dialdehyde

6-[2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,2-dihydro-7-hydroxy-9-methoxy-cyclopenta[c][1]benzopyran-3,4-dione

1,2,3,4-Tetrahydro-alpha,7-dihydroxy-beta-(hydroxymethyl)-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-propanal

alpha-(1,2-Dihydroxyethyl)-1,2,3,4-tetrahydro-7-hydroxy-9-methoxy-3,4-dioxocyclopenta[c][1]benzopyran-6-acetaldehyde

Aflatoxin-M1-8,9-epoxide

Aflatoxin B1-endo-8,9-epoxide

4-(Methylnitrosamino)-1-(1-oxido-3-pyridinyl)-1-butanone

4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanol

7,12-Dimethylbenz[a]anthracene 5,6-oxide

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide

NNAL-N-glucuronide

trans-5,6-Dihydro-5,6-dihydroxy-7,12-dimethylbenz[a]anthracene

Reference

Authors

Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.

Title

Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.

Journal

Drug Metab Rev 34:791-820 (2002)
DOI:10.1081/DMR-120015694

Reference

Authors

Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.

Title

Role of quinones in toxicology.

Journal

Chem Res Toxicol 13:135-60 (2000)
DOI:10.1021/tx9902082

Reference

Authors

Halladay JS, Sauer JM, Sipes IG.

Title

Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.

Journal

Drug Metab Dispos 27:1456-65 (1999)

Reference

Authors

Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.

Title

Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.

Journal

Chem Res Toxicol 12:831-9 (1999)
DOI:10.1021/tx990023v

Reference

Authors

Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.

Title

Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.

Journal

Drug Metab Dispos 32:1032-9 (2004)

Reference

Authors

Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.

Title

Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.

Journal

Drug Metab Dispos 33:1429-37 (2005)
DOI:10.1124/dmd.105.005074

Reference

Authors

Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.

Title

Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.

Journal

Drug Metab Dispos 25:508-15 (1997)

Reference

Authors

Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.

Title

Possible mechanism of liver necrosis caused by aromatic organic compounds.

Journal

Proc Natl Acad Sci U S A 68:160-4 (1971)
DOI:10.1073/pnas.68.1.160

Reference

Authors

Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.

Title

Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.

Journal

Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)

Reference

Authors

Omura T, Ishimura Y, Fujii Y (eds).

Title

[Molecular Biology of P450] (In Japanese)

Journal

Kodansya (2003)

KO pathway

LinkDB

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