KEGG   PATHWAY: pald00260
Entry
pald00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas alloputida
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pald00260  Glycine, serine and threonine metabolism
pald00260

Module
pald_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pald00260]
pald_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pald00260]
pald_M00555  Betaine biosynthesis, choline => betaine [PATH:pald00260]
pald_M00621  Glycine cleavage system [PATH:pald00260]
pald_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pald00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas alloputida [GN:pald]
Gene
LU682_007910  aspartate kinase [KO:K00928] [EC:2.7.2.4]
LU682_021085  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
LU682_023530  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
LU682_003595  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
LU682_000390  homoserine kinase [KO:K02204] [EC:2.7.1.39]
LU682_023525  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
LU682_003585  threonine synthase [KO:K01733] [EC:4.2.3.1]
LU682_001530  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
LU682_001535  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LU682_003630  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LU682_004135  2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
LU682_025080  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
LU682_014635  glycerate kinase [KO:K00865] [EC:2.7.1.165]
LU682_008515  glycerate kinase [KO:K11529] [EC:2.7.1.165]
LU682_027500  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
LU682_028015  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LU682_017965  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LU682_022045  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
LU682_026760  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
LU682_002485  SDR family NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
LU682_027140  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
LU682_028205  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
LU682_005250  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
LU682_028215  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
LU682_005240  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
LU682_029415  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LU682_007985  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LU682_009175  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
LU682_028210  gcvH; glycine cleavage system protein GcvH [KO:K02437]
LU682_005255  gcvH; glycine cleavage system protein GcvH [KO:K02437]
LU682_010550  M24 family metallopeptidase [KO:K08688] [EC:3.5.3.3]
LU682_011660  M24 family metallopeptidase [KO:K08688] [EC:3.5.3.3]
LU682_011675  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K00998] [EC:2.7.8.8]
LU682_025505  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
LU682_003975  CDP-alcohol phosphatidyltransferase family protein [KO:K17103] [EC:2.7.8.8]
LU682_027545  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
LU682_027540  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LU682_003835  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
LU682_001500  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
LU682_001505  gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
LU682_001475  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
LU682_001480  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
LU682_001485  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
LU682_001490  electron transfer flavoprotein subunit beta [KO:K25961]
LU682_011305  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
LU682_001550  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
LU682_013620  2Fe-2S iron-sulfur cluster-binding protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
LU682_001540  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
LU682_013610  FAD-dependent oxidoreductase [KO:K00303] [EC:1.5.3.24 1.5.3.1]
LU682_001555  soxG; sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
LU682_013625  sarcosine oxidase [KO:K00305] [EC:1.5.3.24 1.5.3.1]
LU682_001545  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
LU682_013615  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
LU682_007035  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01758] [EC:4.4.1.1]
LU682_001405  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
LU682_005245  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
LU682_014810  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
LU682_027985  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
LU682_012790  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
LU682_014570  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
LU682_015995  serine/threonine dehydratase family protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
LU682_011580  alr; alanine racemase [KO:K25317] [EC:5.1.1.10]
LU682_000195  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
LU682_000200  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
LU682_008990  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
LU682_016630  diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pald00010  Glycolysis / Gluconeogenesis
pald00020  Citrate cycle (TCA cycle)
pald00230  Purine metabolism
pald00250  Alanine, aspartate and glutamate metabolism
pald00270  Cysteine and methionine metabolism
pald00290  Valine, leucine and isoleucine biosynthesis
pald00300  Lysine biosynthesis
pald00330  Arginine and proline metabolism
pald00460  Cyanoamino acid metabolism
pald00470  D-Amino acid metabolism
pald00564  Glycerophospholipid metabolism
pald00620  Pyruvate metabolism
pald00630  Glyoxylate and dicarboxylate metabolism
pald00640  Propanoate metabolism
pald00680  Methane metabolism
pald00860  Porphyrin metabolism
pald00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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