KEGG   PATHWAY: pdis00020
Entry
pdis00020                   Pathway                                
Name
Citrate cycle (TCA cycle) - Candidatus Pantoea soli
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
pdis00020  Citrate cycle (TCA cycle)
pdis00020

Module
pdis_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:pdis00020]
pdis_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:pdis00020]
pdis_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:pdis00020]
pdis_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:pdis00020]
pdis_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:pdis00020]
Other DBs
GO: 0006099
Organism
Candidatus Pantoea soli [GN:pdis]
Gene
D8B20_05320  citrate synthase [KO:K01647] [EC:2.3.3.1]
D8B20_09125  acnA; aconitate hydratase AcnA [KO:K27802] [EC:4.2.1.3 4.2.1.99]
D8B20_03435  acnB; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase [KO:K01682] [EC:4.2.1.3 4.2.1.99]
D8B20_07130  NADP-dependent isocitrate dehydrogenase [KO:K00031] [EC:1.1.1.42]
D8B20_05345  sucA; 2-oxoglutarate dehydrogenase E1 component [KO:K00164] [EC:1.2.4.2]
D8B20_05350  odhB; 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase [KO:K00658] [EC:2.3.1.61]
D8B20_03430  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
D8B20_05360  sucD; succinate--CoA ligase subunit alpha [KO:K01902] [EC:6.2.1.5]
D8B20_05355  ADP-forming succinate--CoA ligase subunit beta [KO:K01903] [EC:6.2.1.5]
D8B20_05335  succinate dehydrogenase flavoprotein subunit [KO:K00239] [EC:1.3.5.1]
D8B20_05340  succinate dehydrogenase iron-sulfur subunit [KO:K00240] [EC:1.3.5.1]
D8B20_05325  succinate dehydrogenase cytochrome b556 subunit [KO:K00241]
D8B20_05330  succinate dehydrogenase membrane anchor subunit [KO:K00242]
D8B20_07260  fumarate hydratase [KO:K01676] [EC:4.2.1.2]
D8B20_08045  fumC; class II fumarate hydratase [KO:K01679] [EC:4.2.1.2]
D8B20_15425  malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
D8B20_16540  malate:quinone oxidoreductase [KO:K00116] [EC:1.1.5.4]
D8B20_18790  mqo; malate dehydrogenase (quinone) [KO:K00116] [EC:1.1.5.4]
D8B20_16100  pckA; phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
D8B20_03420  aceE; pyruvate dehydrogenase (acetyl-transferring), homodimeric type [KO:K00163] [EC:1.2.4.1]
D8B20_03425  pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
pdis00010  Glycolysis / Gluconeogenesis
pdis00053  Ascorbate and aldarate metabolism
pdis00061  Fatty acid biosynthesis
pdis00071  Fatty acid degradation
pdis00190  Oxidative phosphorylation
pdis00220  Arginine biosynthesis
pdis00250  Alanine, aspartate and glutamate metabolism
pdis00280  Valine, leucine and isoleucine degradation
pdis00350  Tyrosine metabolism
pdis00470  D-Amino acid metabolism
pdis00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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