KEGG   PATHWAY: peq00260
Entry
peq00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Phalaenopsis equestris
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
peq00260  Glycine, serine and threonine metabolism
peq00260

Module
peq_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:peq00260]
peq_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:peq00260]
peq_M00555  Betaine biosynthesis, choline => betaine [PATH:peq00260]
peq_M00621  Glycine cleavage system [PATH:peq00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Phalaenopsis equestris [GN:peq]
Gene
110020225  aspartokinase 2, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
110024472  aspartokinase 2, chloroplastic-like [KO:K00928] [EC:2.7.2.4]
110031494  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
110030190  uncharacterized protein LOC110030190 [KO:K00133] [EC:1.2.1.11]
110036203  uncharacterized protein LOC110036203 isoform X1 [KO:K00003] [EC:1.1.1.3]
110024498  LOW QUALITY PROTEIN: homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
110026949  LOW QUALITY PROTEIN: threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
110027694  probable low-specificity L-threonine aldolase 2 [KO:K01620] [EC:4.1.2.48]
110033632  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
110018217  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
110020284  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
110030505  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
110038981  LOW QUALITY PROTEIN: serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
110035478  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
110019741  glyoxylate/hydroxypyruvate reductase HPR3-like isoform X1 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
110021442  phosphoglycerate mutase-like protein 4 [KO:K15634] [EC:5.4.2.11]
110032367  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
110021570  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
110021598  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
110039453  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110032546  D-3-phosphoglycerate dehydrogenase 1, chloroplastic-like isoform X1 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110025620  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
110020618  phosphoserine aminotransferase 1, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
110024206  phosphoserine phosphatase, chloroplastic [KO:K01079] [EC:3.1.3.3]
110027977  uncharacterized protein LOC110027977 [KO:K00276] [EC:1.4.3.21]
110035221  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
110021265  primary amine oxidase 1-like [KO:K00276] [EC:1.4.3.21]
110036307  primary amine oxidase-like isoform X1 [KO:K00276] [EC:1.4.3.21]
110025500  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
110031439  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
110034093  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
110034825  leghemoglobin reductase-like [KO:K00382] [EC:1.8.1.4]
110039085  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
110030333  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
110023460  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
110037608  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
110021056  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
110032175  glycine cleavage system H protein 3, mitochondrial [KO:K02437]
110020129  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110021374  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110021412  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110023535  glutamate--glyoxylate aminotransferase 2-like [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
110028759  choline monooxygenase, chloroplastic [KO:K00499] [EC:1.14.15.7]
110021819  betaine aldehyde dehydrogenase 1, chloroplastic-like [KO:K00130] [EC:1.2.1.8]
110026035  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110030619  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110023487  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110023743  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
110034507  LOW QUALITY PROTEIN: serine racemase [KO:K12235] [EC:5.1.1.18]
110023543  tryptophan synthase alpha chain-like [KO:K01695] [EC:4.2.1.20]
110023544  tryptophan synthase alpha chain-like isoform X1 [KO:K01695] [EC:4.2.1.20]
110032153  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
peq00010  Glycolysis / Gluconeogenesis
peq00020  Citrate cycle (TCA cycle)
peq00230  Purine metabolism
peq00250  Alanine, aspartate and glutamate metabolism
peq00270  Cysteine and methionine metabolism
peq00290  Valine, leucine and isoleucine biosynthesis
peq00300  Lysine biosynthesis
peq00330  Arginine and proline metabolism
peq00460  Cyanoamino acid metabolism
peq00470  D-Amino acid metabolism
peq00564  Glycerophospholipid metabolism
peq00600  Sphingolipid metabolism
peq00620  Pyruvate metabolism
peq00630  Glyoxylate and dicarboxylate metabolism
peq00640  Propanoate metabolism
peq00860  Porphyrin metabolism
peq00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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