KEGG   PATHWAY: pfn02020
Entry
pfn02020                    Pathway                                
Name
Two-component system - Pseudomonas fluorescens UK4
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
pfn02020  Two-component system
pfn02020

Other DBs
GO: 0000160
Organism
Pseudomonas fluorescens UK4 [GN:pfn]
Gene
HZ99_17105  histidine kinase [KO:K07636] [EC:2.7.13.3]
HZ99_17100  transcriptional regulator PhoB [KO:K07657]
HZ99_12735  alkaline phosphatase [KO:K01113] [EC:3.1.3.1]
HZ99_17145  phosphate-binding protein [KO:K02040]
HZ99_05950  membrane protein [KO:K02040]
HZ99_09325  histidine kinase [KO:K07637] [EC:2.7.13.3]
HZ99_09330  transcriptional regulator [KO:K07660]
HZ99_08610  multidrug transporter [KO:K07790]
HZ99_19395  ATPase [KO:K07638] [EC:2.7.13.3]
HZ99_19390  chemotaxis protein CheY [KO:K07659]
HZ99_10435  chemotaxis protein CheY [KO:K07662]
HZ99_09340  histidine kinase [KO:K07639] [EC:2.7.13.3]
HZ99_09345  chemotaxis protein CheY [KO:K07661]
HZ99_25000  serine peptidase [KO:K04771] [EC:3.4.21.107]
HZ99_15325  histidine kinase [KO:K07641] [EC:2.7.13.3]
HZ99_15330  transcriptional regulator [KO:K07663]
HZ99_03860  secretion protein HlyD [KO:K07799]
HZ99_03855  multidrug transporter [KO:K07788]
HZ99_03850  acriflavine resistance protein B [KO:K07789]
HZ99_09560  UDP-4-amino-4-deoxy-L-arabinose-oxoglutarate aminotransferase [KO:K07806] [EC:2.6.1.87]
HZ99_17555  ATPase [KO:K07644] [EC:2.7.13.3]
HZ99_12065  histidine kinase [KO:K07644] [EC:2.7.13.3]
HZ99_22560  histidine kinase [KO:K07644] [EC:2.7.13.3]
HZ99_08040  transcriptional regulator [KO:K07665]
HZ99_17560  transcriptional regulator [KO:K07665]
HZ99_12060  transcriptional regulator [KO:K07665]
HZ99_22540  transcriptional regulator [KO:K07665]
HZ99_22565  transcriptional regulator [KO:K07665]
HZ99_04940  heat-shock protein HtpX [KO:K07810]
HZ99_17535  RND transporter [KO:K07798]
HZ99_04950  RND transporter [KO:K07798]
HZ99_17530  cation transporter [KO:K07787]
HZ99_04945  cation transporter [KO:K07787]
HZ99_27745  histidine kinase [KO:K07645] [EC:2.7.13.3]
HZ99_02845  histidine kinase [KO:K07645] [EC:2.7.13.3]
HZ99_27740  transcriptional regulator [KO:K07666]
HZ99_02850  XRE family transcriptional regulator [KO:K07666]
HZ99_25820  flagellin [KO:K02406]
HZ99_25975  fliA; flagellar biosynthesis sigma factor [KO:K02405]
HZ99_20605  flagellar motor protein MotA [KO:K02556]
HZ99_26000  motC; flagellar motor protein [KO:K02556]
HZ99_27235  histidine kinase [KO:K07646] [EC:2.7.13.3]
HZ99_27240  transcriptional regulator [KO:K07667]
HZ99_27220  ATPase [KO:K01546]
HZ99_27225  potassium-transporting ATPase subunit B [KO:K01547] [EC:7.2.2.6]
HZ99_27230  ATPase [KO:K01548]
HZ99_24955  histidine kinase [KO:K07649] [EC:2.7.13.3]
HZ99_24950  transcriptional regulator [KO:K07774]
HZ99_24930  tripartite tricarboxylate transporter TctA [KO:K07793]
HZ99_24935  membrane protein [KO:K07794]
HZ99_24940  tricarboxylic transport membrane protein [KO:K07795]
HZ99_18155  cytochrome B561 [KO:K02259] [EC:1.17.99.9]
HZ99_17840  chromosomal replication initiation protein [KO:K02313]
HZ99_11075  membrane protein [KO:K14205] [EC:2.3.2.3]
HZ99_01210  ATPase [KO:K18072] [EC:2.7.13.3]
HZ99_01205  transcriptional regulator [KO:K18073]
HZ99_23690  hypothetical protein [KO:K18093] [EC:3.4.21.-]
HZ99_10665  porin [KO:K18093] [EC:3.4.21.-]
HZ99_00670  histidine kinase [KO:K19609] [EC:2.7.13.3]
HZ99_00675  transcriptional regulator [KO:K19610]
HZ99_12680  outer membrane receptor protein [KO:K19611]
HZ99_16685  chemotaxis protein CheY [KO:K08083]
HZ99_11915  GDP-mannose dehydrogenase [KO:K00066] [EC:1.1.1.132]
HZ99_04490  histidine kinase [KO:K07673] [EC:2.7.13.3]
HZ99_04495  hypothetical protein [KO:K07684]
HZ99_04475  narZ; nitrate reductase [KO:K00370] [EC:1.7.5.1 1.7.99.-]
HZ99_04470  narH; nitrate reductase [KO:K00371] [EC:1.7.5.1 1.7.99.-]
HZ99_04460  nitrate reductase [KO:K00374] [EC:1.7.5.1 1.7.99.-]
HZ99_04465  nitrate reductase [KO:K00373]
HZ99_03570  histidine kinase [KO:K07677] [EC:2.7.13.3]
HZ99_03580  chemotaxis protein CheY [KO:K07677] [EC:2.7.13.3]
HZ99_23885  LuxR family transcriptional regulator [KO:K07687]
HZ99_11790  response regulator receiver protein [KO:K07687]
HZ99_03585  LuxR family transcriptional regulator [KO:K07687]
HZ99_09250  chemotaxis protein CheY [KO:K07678] [EC:2.7.13.3]
HZ99_05135  chemotaxis protein CheY [KO:K07689]
HZ99_26940  carbon storage regulator [KO:K03563]
HZ99_07400  carbon storage regulator CsrA [KO:K03563]
HZ99_09860  carbon storage regulator [KO:K03563]
HZ99_27515  histidine kinase [KO:K07679] [EC:2.7.13.3]
HZ99_23875  histidine kinase [KO:K07679] [EC:2.7.13.3]
HZ99_00305  histidine kinase [KO:K07679] [EC:2.7.13.3]
HZ99_01810  LuxR family transcriptional regulator [KO:K07690]
HZ99_00300  LuxR family transcriptional regulator [KO:K07690]
HZ99_11320  LuxR family transcriptional regulator [KO:K07690]
HZ99_27520  LuxR family transcriptional regulator [KO:K07690]
HZ99_02020  ampC; beta-lactamase/D-alanine carboxypeptidase [KO:K01467] [EC:3.5.2.6]
HZ99_21205  histidine kinase [KO:K27076] [EC:2.7.13.3]
HZ99_21220  LuxR family transcriptional regulator [KO:K27077]
HZ99_20055  O-succinylbenzoate--CoA ligase [KO:K07347]
HZ99_01795  fimbrial protein [KO:K07347]
HZ99_03600  fimbrial protein [KO:K07347]
HZ99_21265  pilus assembly protein [KO:K02651]
HZ99_21275  pilus assembly protein [KO:K02651]
HZ99_21260  pilus assembly protein CpaB [KO:K02279]
HZ99_21255  secretin [KO:K02280]
HZ99_21250  pilus assembly protein [KO:K02282]
HZ99_21245  ATPase [KO:K02283] [EC:7.4.2.8]
HZ99_21240  type II secretion system protein F [KO:K12510]
HZ99_21235  type II secretion system protein F [KO:K12511]
HZ99_21230  hypothetical protein [KO:K27079]
HZ99_21200  hypothetical protein [KO:K27080]
HZ99_24135  glnD; protein-PII uridylyltransferase [KO:K00990] [EC:2.7.7.59]
HZ99_19810  histidine kinase [KO:K07708] [EC:2.7.13.3]
HZ99_19805  glnG; nitrogen regulation protein NR(I) [KO:K07712]
HZ99_19815  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
HZ99_25210  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
HZ99_06435  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
HZ99_06775  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
HZ99_16300  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
HZ99_16310  gamma-glutamylputrescine synthetase [KO:K01915] [EC:6.3.1.2]
HZ99_22330  Fis family transcriptional regulator [KO:K07713]
HZ99_22525  Short chain fatty acid transporter [KO:K02106]
HZ99_00995  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
HZ99_02635  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
HZ99_08960  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
HZ99_25115  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
HZ99_06495  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
HZ99_21300  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
HZ99_19505  ATPase [KO:K10125] [EC:2.7.13.3]
HZ99_10815  cytochrome C biogenesis protein CcmE [KO:K10125] [EC:2.7.13.3]
HZ99_19500  Fis family transcriptional regulator [KO:K10126]
HZ99_10820  C4-dicarboxylate ABC transporter [KO:K10126]
HZ99_01110  C4-dicarboxylate ABC transporter [KO:K11103]
HZ99_09315  C4-dicarboxylate transporter [KO:K11103]
HZ99_12400  RNA polymerase factor sigma-54 [KO:K03092]
HZ99_12810  fimbrial protein [KO:K02650]
HZ99_18260  histidine kinase [KO:K11383] [EC:2.7.13.3]
HZ99_18265  chemotaxis protein CheY [KO:K11384]
HZ99_09475  chemotaxis protein [KO:K00575] [EC:2.1.1.80]
HZ99_02580  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
HZ99_16820  chemotaxis protein [KO:K03406]
HZ99_10175  pili assembly chaperone [KO:K03406]
HZ99_19980  chemotaxis protein [KO:K03406]
HZ99_19985  chemotaxis protein [KO:K03406]
HZ99_10725  chemotaxis protein [KO:K03406]
HZ99_10905  chemotaxis protein [KO:K03406]
HZ99_20350  chemotaxis protein [KO:K03406]
HZ99_06185  chemotaxis protein [KO:K03406]
HZ99_06615  chemotaxis protein [KO:K03406]
HZ99_06625  chemotaxis protein [KO:K03406]
HZ99_26315  chemotaxis protein [KO:K03406]
HZ99_12245  chemotaxis protein [KO:K03406]
HZ99_21875  chemotaxis protein [KO:K03406]
HZ99_26420  chemotaxis protein [KO:K03406]
HZ99_02675  chemotaxis protein [KO:K03406]
HZ99_12770  chemotaxis protein [KO:K03406]
HZ99_03420  hypothetical protein [KO:K03406]
HZ99_22585  chemotaxis protein [KO:K03406]
HZ99_18430  chemotaxis protein [KO:K03406]
HZ99_04430  chemotaxis protein [KO:K03406]
HZ99_10025  chemotaxis protein [KO:K03406]
HZ99_10045  chemotaxis protein [KO:K03406]
HZ99_08250  chemotaxis protein [KO:K03776]
HZ99_08400  chemotaxis protein [KO:K03776]
HZ99_12035  chemotaxis protein [KO:K03776]
HZ99_26015  chemotaxis protein CheW [KO:K03408]
HZ99_26020  chemotaxis protein CheW [KO:K03408]
HZ99_25990  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
HZ99_25980  histidine kinase [KO:K03413]
HZ99_02585  chemotaxis protein CheB [KO:K03412] [EC:3.1.1.61 3.5.1.44]
HZ99_25995  chemotaxis protein CheY [KO:K03412] [EC:3.1.1.61 3.5.1.44]
HZ99_09480  chemotaxis protein CheW [KO:K03415]
HZ99_12020  chemotaxis protein CheW [KO:K03415]
HZ99_27620  chemotaxis protein CheW [KO:K03415]
HZ99_15845  chemotaxis protein [KO:K02660]
HZ99_15850  protein PilI [KO:K02659]
HZ99_15840  histidine kinase [KO:K06596]
HZ99_15860  pilus assembly protein PilG [KO:K02657]
HZ99_15855  chemotaxis protein CheY [KO:K02658]
HZ99_15835  chemotaxis protein [KO:K06598]
HZ99_10960  chemotaxis protein CheR [KO:K13486]
HZ99_10970  chemotaxis protein [KO:K13487]
HZ99_10965  chemotaxis protein CheW [KO:K13488]
HZ99_10955  chemotaxis protein CheW [KO:K13489]
HZ99_10950  chemotaxis protein CheA [KO:K13490]
HZ99_10945  chemotaxis protein CheY [KO:K13491] [EC:3.1.1.61]
HZ99_10940  diguanylate cyclase [KO:K11444] [EC:2.7.7.65]
HZ99_23310  histidine kinase [KO:K11354] [EC:2.7.13.3]
HZ99_02595  chemotaxis protein CheY [KO:K13589]
HZ99_25845  ATPase AAA [KO:K10941]
HZ99_25850  histidine kinase [KO:K10942] [EC:2.7.13.3]
HZ99_25855  Fis family transcriptional regulator [KO:K10943]
HZ99_11425  histidine kinase [KO:K17060] [EC:2.7.13.3]
HZ99_11430  Fis family transcriptional regulator [KO:K17061]
HZ99_11420  amino acid ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
HZ99_11415  amino acid ABC transporter permease [KO:K10002]
HZ99_11410  amino acid ABC transporter permease [KO:K10003]
HZ99_11405  ABC transporter [KO:K10001]
HZ99_07380  glutaminase [KO:K05597] [EC:3.5.1.38]
HZ99_14625  cyclic AMP receptor protein [KO:K10914]
HZ99_18825  Crp/Fnr family transcriptional regulator [KO:K10914]
HZ99_12615  histidine kinase [KO:K15011] [EC:2.7.13.3]
HZ99_12610  chemotaxis protein CheY [KO:K15012]
HZ99_12560  ubiquinol-cytochrome C reductase [KO:K00411] [EC:7.1.1.8]
HZ99_12555  cytochrome B [KO:K00412]
HZ99_12550  cytochrome C [KO:K00413]
HZ99_23330  cytochrome C [KO:K08738]
HZ99_25205  calcium channel protein [KO:K08738]
HZ99_02470  cbb3-type cytochrome c oxidase subunit I [KO:K00404] [EC:7.1.1.9]
HZ99_08280  cbb3-type cytochrome c oxidase subunit I [KO:K00404] [EC:7.1.1.9]
HZ99_08300  cbb3-type cytochrome c oxidase subunit I [KO:K00404] [EC:7.1.1.9]
HZ99_08285  cbb3-type cytochrome c oxidase subunit II [KO:K00405]
HZ99_08305  cbb3-type cytochrome c oxidase subunit II [KO:K00405]
HZ99_08290  cytochrome C oxidase [KO:K00407]
HZ99_08310  cytochrome oxidase [KO:K00407]
HZ99_08295  cytochrome Cbb3 [KO:K00406]
HZ99_08315  cytochrome Cbb3 [KO:K00406]
HZ99_13145  cytochrome D ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
HZ99_13140  ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
HZ99_20520  channel protein TolC [KO:K12340]
HZ99_04625  membrane protein [KO:K12340]
HZ99_09210  protein tyrosine phosphatase [KO:K25307] [EC:3.1.3.48]
HZ99_08225  UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase [KO:K02472] [EC:1.1.1.336]
HZ99_01160  acyl-homoserine-lactone synthase [KO:K13061] [EC:2.3.1.184]
HZ99_23145  RNA polymerase sigma factor [KO:K23514]
HZ99_15290  RNA polymerase sigma factor [KO:K23514]
HZ99_02125  RNA polymerase subunit sigma-70 [KO:K23514]
HZ99_00145  RNA polymerase sigma factor [KO:K23514]
HZ99_26620  RNA polymerase sigma factor [KO:K23514]
HZ99_18535  RNA polymerase sigma factor [KO:K23514]
HZ99_26615  histidine kinase [KO:K07165]
HZ99_15295  amino acid ABC transporter substrate-binding protein [KO:K07165]
HZ99_24760  iron dicitrate transport regulator FecR [KO:K07165]
HZ99_06750  peptide ABC transporter substrate-binding protein [KO:K07165]
HZ99_17295  iron dicitrate transport regulator FecR [KO:K07165]
HZ99_04075  peptide ABC transporter substrate-binding protein [KO:K07165]
HZ99_18540  iron dicitrate transport regulator FecR [KO:K07165]
HZ99_23140  membrane protein [KO:K07165]
HZ99_23170  sugar ABC transporter substrate-binding protein [KO:K07165]
HZ99_07450  hypothetical protein [KO:K07165]
HZ99_02130  iron dicitrate transport regulator FecR [KO:K07165]
HZ99_00060  siderophore-interacting protein [KO:K07165]
HZ99_00140  siderophore-interacting protein [KO:K07165]
HZ99_10885  glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K07165]
HZ99_13175  siderophore-interacting protein [KO:K07165]
HZ99_00785  iron dicitrate transport regulator FecR [KO:K07165]
HZ99_02065  iron dicitrate transport regulator FecR [KO:K07165]
HZ99_27500  histidine kinase [KO:K20973] [EC:2.7.13.3]
HZ99_26330  histidine kinase [KO:K20974] [EC:2.7.13.3]
HZ99_25900  histidine kinase [KO:K20976]
HZ99_25895  chemotaxis protein CheY [KO:K20977]
HZ99_25890  anti-anti-sigma factor [KO:K20978]
HZ99_09490  flagellar biosynthesis anti-sigma factor FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
  Authors
Epstein W.
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Related
pathway
pfn00190  Oxidative phosphorylation
pfn00550  Peptidoglycan biosynthesis
pfn00910  Nitrogen metabolism
pfn02030  Bacterial chemotaxis
pfn02040  Flagellar assembly
pfn03070  Bacterial secretion system
KO pathway
ko02020   
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