KEGG   PATHWAY: pig00260
Entry
pig00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pigmentiphaga sp. H8
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pig00260  Glycine, serine and threonine metabolism
pig00260

Module
pig_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pig00260]
pig_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pig00260]
pig_M00033  Ectoine biosynthesis, aspartate => ectoine [PATH:pig00260]
pig_M00621  Glycine cleavage system [PATH:pig00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pigmentiphaga sp. H8 [GN:pig]
Gene
EGT29_09760  aspartate kinase [KO:K00928] [EC:2.7.2.4]
EGT29_16030  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
EGT29_15395  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
EGT29_09270  homoserine kinase [KO:K02204] [EC:2.7.1.39]
EGT29_15390  threonine synthase [KO:K01733] [EC:4.2.3.1]
EGT29_22475  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
EGT29_13880  alanine--glyoxylate aminotransferase family protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
EGT29_00525  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
EGT29_25495  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
EGT29_04440  glycerate kinase [KO:K11529] [EC:2.7.1.165]
EGT29_25145  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
EGT29_22590  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
EGT29_27820  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EGT29_03580  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EGT29_19860  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EGT29_14790  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
EGT29_08730  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
EGT29_13110  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
EGT29_03450  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
EGT29_05585  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
EGT29_05575  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
EGT29_11740  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EGT29_12855  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
EGT29_05580  gcvH; glycine cleavage system protein GcvH [KO:K02437]
EGT29_17140  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
EGT29_21790  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EGT29_03165  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EGT29_00425  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EGT29_14275  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EGT29_10215  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EGT29_03305  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EGT29_05170  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
EGT29_01360  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
EGT29_03550  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
EGT29_24280  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
EGT29_16000  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
EGT29_16005  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
EGT29_07180  ectB; diaminobutyrate--2-oxoglutarate transaminase [KO:K00836] [EC:2.6.1.76]
EGT29_07175  ectA; diaminobutyrate acetyltransferase [KO:K06718] [EC:2.3.1.178]
EGT29_07185  ectoine synthase [KO:K06720] [EC:4.2.1.108]
EGT29_07190  thpD; ectoine hydroxylase [KO:K10674] [EC:1.14.11.55]
EGT29_03410  aminopeptidase P family protein [KO:K15783] [EC:3.5.4.44]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pig00010  Glycolysis / Gluconeogenesis
pig00020  Citrate cycle (TCA cycle)
pig00230  Purine metabolism
pig00250  Alanine, aspartate and glutamate metabolism
pig00270  Cysteine and methionine metabolism
pig00290  Valine, leucine and isoleucine biosynthesis
pig00300  Lysine biosynthesis
pig00330  Arginine and proline metabolism
pig00460  Cyanoamino acid metabolism
pig00470  D-Amino acid metabolism
pig00564  Glycerophospholipid metabolism
pig00620  Pyruvate metabolism
pig00630  Glyoxylate and dicarboxylate metabolism
pig00640  Propanoate metabolism
pig00680  Methane metabolism
pig00860  Porphyrin metabolism
pig00920  Sulfur metabolism
KO pathway
ko00260   
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