KEGG PATHWAY: pls00270

PATHWAY: pls00270

Entry

pls00270                    Pathway

Name

Cysteine and methionine metabolism - Planctomyces sp. SH-PL14

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

pls00270

Cysteine and methionine metabolism

Module

pls_M00021

Cysteine biosynthesis, serine => cysteine [PATH:pls00270]

Other DBs

GO:	0006534 0006555

Organism

Planctomyces sp. SH-PL14 [GN:pls]

Gene

VT03_06375

cysE_1; Serine acetyltransferase [KO:K00640] [EC:2.3.1.30]

VT03_24720

cysE_2; Serine acetyltransferase [KO:K00640] [EC:2.3.1.30]

VT03_29525

cysE_3; Serine acetyltransferase [KO:K00640] [EC:2.3.1.30]

VT03_25785

cysK1_1; O-acetylserine sulfhydrylase [KO:K01738] [EC:2.5.1.47]

VT03_29485

cysK1_2; O-acetylserine sulfhydrylase [KO:K01738] [EC:2.5.1.47]

VT03_29520

cysK1_3; O-acetylserine sulfhydrylase [KO:K01738] [EC:2.5.1.47]

VT03_00610

metH; Methionine synthase [KO:K00548] [EC:2.1.1.13]

VT03_04385

metK; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]

VT03_14670

speE_1; Spermidine synthase [KO:K00797] [EC:2.5.1.16]

VT03_19995

speE_3; Spermidine synthase [KO:K00797] [EC:2.5.1.16]

VT03_30600

mtnN; Aminodeoxyfutalosine nucleosidase [KO:K01243] [EC:3.2.2.9]

VT03_04850

mtnA; Methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

VT03_10490

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase [KO:K08966] [EC:3.1.3.87]

VT03_13810

msrC; Free methionine-R-sulfoxide reductase [KO:K08968] [EC:1.8.4.14]

VT03_05975

dcm; DNA-cytosine methyltransferase [KO:K00558] [EC:2.1.1.37]

VT03_24835

ahcY_2; Adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]

VT03_01410

ahcY_1; Adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]

VT03_28425

lysC; Aspartokinase [KO:K00928] [EC:2.7.2.4]

VT03_00050

asd; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

VT03_03160

hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

VT03_00440

metX_1; Homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

VT03_09270

metX_2; Homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

VT03_05590

mdeA; Methionine gamma-lyase [KO:K01740] [EC:2.5.1.49]

VT03_29320

ilvE; Branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]

VT03_12025

dat_1; D-alanine aminotransferase [KO:K00826] [EC:2.6.1.42]

VT03_32165

cdoA; Cysteine dioxygenase [KO:K00456] [EC:1.13.11.20]

VT03_01640

Aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]

VT03_02850

patA_1; Putative N-acetyl-LL-diaminopimelate aminotransferase [KO:K00812] [EC:2.6.1.1]

VT03_16290

rhdA; Putative thiosulfate sulfurtransferase precursor [KO:K01011] [EC:2.8.1.1 2.8.1.2]

VT03_30155

ldh_2; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

VT03_10485

ldh_1; L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]

VT03_12825

mdh; Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

VT03_17420

serA_1; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

VT03_15565

hprA_2; Glycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

VT03_04085

serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors