KEGG   PATHWAY: pos00260
Entry
pos00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Polaromonas sp. SP1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pos00260  Glycine, serine and threonine metabolism
pos00260

Module
pos_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pos00260]
pos_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pos00260]
pos_M00621  Glycine cleavage system [PATH:pos00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Polaromonas sp. SP1 [GN:pos]
Gene
DT070_20020  aspartate kinase [KO:K00928] [EC:2.7.2.4]
DT070_12300  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
DT070_19300  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
DT070_00465  homoserine kinase [KO:K02204] [EC:2.7.1.39]
DT070_07365  pyridoxal-phosphate dependent enzyme [KO:K01733] [EC:4.2.3.1]
DT070_19295  threonine synthase [KO:K01733] [EC:4.2.3.1]
DT070_08520  low-specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
DT070_20115  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DT070_06305  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
DT070_15040  aminotransferase class V-fold PLP-dependent enzyme [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
DT070_09330  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
DT070_14700  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
DT070_01260  glycerate kinase [KO:K11529] [EC:2.7.1.165]
DT070_10775  2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
DT070_09570  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
DT070_03820  hydroxyacid dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DT070_16975  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DT070_17610  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
DT070_00170  3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
DT070_18710  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
DT070_20680  gcvP; glycine dehydrogenase (aminomethyl-transferring) [KO:K00281] [EC:1.4.4.2]
DT070_20670  glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
DT070_18125  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DT070_18450  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DT070_20675  gcvH; glycine cleavage system protein GcvH [KO:K02437]
DT070_15790  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
DT070_20390  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
DT070_06185  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
DT070_08870  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
DT070_10040  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
DT070_11125  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
DT070_09655  amino acid deaminase [KO:K01753] [EC:4.3.1.18]
DT070_12265  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
DT070_12270  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pos00010  Glycolysis / Gluconeogenesis
pos00020  Citrate cycle (TCA cycle)
pos00230  Purine metabolism
pos00250  Alanine, aspartate and glutamate metabolism
pos00270  Cysteine and methionine metabolism
pos00290  Valine, leucine and isoleucine biosynthesis
pos00300  Lysine biosynthesis
pos00330  Arginine and proline metabolism
pos00460  Cyanoamino acid metabolism
pos00470  D-Amino acid metabolism
pos00564  Glycerophospholipid metabolism
pos00620  Pyruvate metabolism
pos00630  Glyoxylate and dicarboxylate metabolism
pos00640  Propanoate metabolism
pos00680  Methane metabolism
pos00860  Porphyrin metabolism
pos00920  Sulfur metabolism
KO pathway
ko00260   
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