KEGG   PATHWAY: pou00260
Entry
pou00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Penicillium oxalicum
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pou00260  Glycine, serine and threonine metabolism
pou00260

Module
pou_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pou00260]
pou_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pou00260]
pou_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pou00260]
pou_M00621  Glycine cleavage system [PATH:pou00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Penicillium oxalicum [GN:pou]
Gene
POX_e06337  Aspartokinase [KO:K00928] [EC:2.7.2.4]
POX_g08820  Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
POX_e06604  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
POX_b03128  Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
POX_e06316  Homoserine kinase [KO:K00872] [EC:2.7.1.39]
POX_g08905  Threonine synthase [KO:K01733] [EC:4.2.3.1]
POX_h09691  Aldolase vrtJ [KO:K01620] [EC:4.1.2.48]
POX_a01531  hypothetical protein [KO:K01620] [EC:4.1.2.48]
POX_f08195  putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
POX_b02971  Serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]
POX_d05765  hypothetical protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
POX_b02973  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
POX_b02273  hypothetical protein [KO:K15918] [EC:2.7.1.31]
POX_e06350  D-3-phosphoglycerate dehydrogenase 2 [KO:K00058] [EC:1.1.1.95 1.1.1.399]
POX_a00945  hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
POX_c04491  Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
POX_g08640  Phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
POX_d05219  NADP-dependent 3-hydroxy acid dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
POX_f08526  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
POX_a00696  5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
POX_g08539  Copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
POX_f08031  Peroxisomal primary amine oxidase [KO:K00276] [EC:1.4.3.21]
POX_f08379  Copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
POX_a00301  Copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
POX_c04084  Copper amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
POX_g09255  Glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
POX_d05579  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
POX_g08941  Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
POX_c04167  Glycine cleavage system H protein [KO:K02437]
POX_d06014  hypothetical protein [KO:K00273] [EC:1.4.3.3]
POX_e07171  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
POX_d05173  hypothetical protein [KO:K00273] [EC:1.4.3.3]
POX_d05210  D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
POX_a01702  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
POX_c04405  NAD/NADP-dependent betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
POX_a01473  Dimethylglycine oxidase [KO:K00309] [EC:1.5.3.10]
POX_g08928  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
POX_a01045  L-pipecolate oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
POX_b03226  hypothetical protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
POX_f08136  Cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
POX_c04366  Cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
POX_g08554  hypothetical protein [KO:K01754] [EC:4.3.1.19]
POX_b02341  Threonine dehydratase [KO:K01754] [EC:4.3.1.19]
POX_b02308  Serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
POX_e06808  Tryptophan synthase [KO:K01694] [EC:4.2.1.20]
POX_a01284  Tryptophan synthase [KO:K01694] [EC:4.2.1.20]
POX_a01862  Tryptophan synthase [KO:K01694] [EC:4.2.1.20]
POX_b03040  Tryptophan synthase [KO:K01694] [EC:4.2.1.20]
POX_g09268  Tryptophan synthase beta chain 1 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pou00010  Glycolysis / Gluconeogenesis
pou00020  Citrate cycle (TCA cycle)
pou00230  Purine metabolism
pou00250  Alanine, aspartate and glutamate metabolism
pou00270  Cysteine and methionine metabolism
pou00290  Valine, leucine and isoleucine biosynthesis
pou00300  Lysine biosynthesis
pou00330  Arginine and proline metabolism
pou00460  Cyanoamino acid metabolism
pou00470  D-Amino acid metabolism
pou00564  Glycerophospholipid metabolism
pou00600  Sphingolipid metabolism
pou00620  Pyruvate metabolism
pou00630  Glyoxylate and dicarboxylate metabolism
pou00640  Propanoate metabolism
pou00680  Methane metabolism
pou00860  Porphyrin metabolism
pou00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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