KEGG   PATHWAY: psco00260
Entry
psco00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Mollisia scopiformis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
psco00260  Glycine, serine and threonine metabolism
psco00260

Module
psco_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:psco00260]
psco_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:psco00260]
psco_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:psco00260]
psco_M00621  Glycine cleavage system [PATH:psco00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Mollisia scopiformis [GN:psco]
Gene
LY89DRAFT_661399  aspartate kinase [KO:K00928] [EC:2.7.2.4]
LY89DRAFT_641170  aspartate kinase-like protein [KO:K00928] [EC:2.7.2.4]
LY89DRAFT_712104  aspartate semialdehyde dehydrogenase-like protein [KO:K00133] [EC:1.2.1.11]
LY89DRAFT_682288  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
LY89DRAFT_641088  homoserine kinase [KO:K00872] [EC:2.7.1.39]
LY89DRAFT_679907  putative threonine synthase [KO:K01733] [EC:4.2.3.1]
LY89DRAFT_590884  aromatic amino acid beta-eliminating lyase/threonine aldolase [KO:K01620] [EC:4.1.2.48]
LY89DRAFT_701499  l-allo-threonine aldolase [KO:K01620] [EC:4.1.2.48]
LY89DRAFT_629746  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
LY89DRAFT_669656  beta-eliminating lyase [KO:K01620] [EC:4.1.2.48]
LY89DRAFT_681106  uncharacterized protein [KO:K01620] [EC:4.1.2.48]
LY89DRAFT_688445  SHMT-domain-containing protein [KO:K00600] [EC:2.1.2.1]
LY89DRAFT_649169  cytosolic putative serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
LY89DRAFT_668516  alanine--glyoxylate aminotransferase-like protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
LY89DRAFT_626113  uncharacterized protein [KO:K15633] [EC:5.4.2.12]
LY89DRAFT_689629  D-glycerate 3-kinase [KO:K15918] [EC:2.7.1.31]
LY89DRAFT_473835  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LY89DRAFT_756891  d-3-phosphoglycerate dehydrogenase-like protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
LY89DRAFT_731324  phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
LY89DRAFT_686831  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
LY89DRAFT_612925  NAD(P)-binding protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
LY89DRAFT_692212  NAD(P)-binding protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
LY89DRAFT_202082  tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase [KO:K00643] [EC:2.3.1.37]
LY89DRAFT_573056  putative flavin-containing amine oxidase [KO:K00274] [EC:1.4.3.4]
LY89DRAFT_696355  FAD/NAD(P)-binding domain-containing protein [KO:K00274] [EC:1.4.3.4]
LY89DRAFT_786167  uncharacterized protein [KO:K00274] [EC:1.4.3.4]
LY89DRAFT_704657  putative copper amine oxidase [KO:K00276] [EC:1.4.3.21]
LY89DRAFT_628154  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
LY89DRAFT_741504  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
LY89DRAFT_745382  amine oxidase catalytic domain-containing protein [KO:K00276] [EC:1.4.3.21]
LY89DRAFT_640433  peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
LY89DRAFT_582517  putative membrane copper amine oxidase [KO:K00276] [EC:1.4.3.21]
LY89DRAFT_602519  copper amine oxidase [KO:K00276] [EC:1.4.3.21]
LY89DRAFT_588672  uncharacterized protein [KO:K00276] [EC:1.4.3.21]
LY89DRAFT_341674  glycine dehydrogenase-like protein [KO:K00281] [EC:1.4.4.2]
LY89DRAFT_682129  aminomethyltransferase-like protein [KO:K00605] [EC:2.1.2.10]
LY89DRAFT_689276  dihydrolipoyl dehydrogenase-like protein [KO:K00382] [EC:1.8.1.4]
LY89DRAFT_729230  glycine cleavage system H protein [KO:K02437]
LY89DRAFT_707731  FAD dependent oxidoreductase [KO:K00273] [EC:1.4.3.3]
LY89DRAFT_688126  putative D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
LY89DRAFT_769781  nucleotide-binding domain-containing protein [KO:K00273] [EC:1.4.3.3]
LY89DRAFT_779260  putative D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
LY89DRAFT_391867  aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
LY89DRAFT_715859  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_787229  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_736888  putative fructosyl amino acid oxidasesarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_741083  sarcosine oxidase-like protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_742695  sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_652452  sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_782382  FAD/NAD(P)-binding domain-containing protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_728368  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_687101  FAD dependent oxidoreductase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_656773  fructosyl amine:oxygen oxidoreductase-like protein [KO:K00306] [EC:1.5.3.1 1.5.3.7]
LY89DRAFT_706011  putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
LY89DRAFT_236940  uncharacterized protein [KO:K01758] [EC:4.4.1.1]
LY89DRAFT_679166  threonine dehydratase-like protein [KO:K01754] [EC:4.3.1.19]
LY89DRAFT_216023  IlvA, threonine dehydratase [KO:K01754] [EC:4.3.1.19]
LY89DRAFT_697496  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K01754] [EC:4.3.1.19]
LY89DRAFT_733763  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K01754] [EC:4.3.1.19]
LY89DRAFT_709600  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
LY89DRAFT_619485  tryptophan synthase beta subunit-like PLP-dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
LY89DRAFT_605405  uncharacterized protein [KO:K20498] [EC:4.3.1.18]
LY89DRAFT_645282  uncharacterized protein [KO:K20498] [EC:4.3.1.18]
LY89DRAFT_785190  tryptophan synthase [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
psco00010  Glycolysis / Gluconeogenesis
psco00020  Citrate cycle (TCA cycle)
psco00230  Purine metabolism
psco00250  Alanine, aspartate and glutamate metabolism
psco00270  Cysteine and methionine metabolism
psco00290  Valine, leucine and isoleucine biosynthesis
psco00300  Lysine biosynthesis
psco00330  Arginine and proline metabolism
psco00460  Cyanoamino acid metabolism
psco00470  D-Amino acid metabolism
psco00564  Glycerophospholipid metabolism
psco00600  Sphingolipid metabolism
psco00620  Pyruvate metabolism
psco00630  Glyoxylate and dicarboxylate metabolism
psco00640  Propanoate metabolism
psco00680  Methane metabolism
psco00860  Porphyrin metabolism
psco00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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